| Stonepine Capital Management, LLC |
| 0.95% | — | #1 | $6.2M | 447,160 | $0 | 0 | +447,160 | New Buy |
| Aberdeen Group plc |
| 0.01% | — | #6 | $5.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Nantahala Capital Management, LLC |
| 0.18% | — | #4 | $5.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| EcoR1 Capital, LLC |
| 0.27% | — | #3 | $5.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Samsara BioCapital, LLC |
| 0.46% | — | #2 | $5.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| Siren, L.L.C. |
| 0.11% | — | #5 | $5.6M | 400,000 | $0 | 0 | +400,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #10 | $1.1M | 78,680 | $0 | 0 | +78,680 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #9 | $147,156 | 10,602 | $0 | 0 | +10,602 | New Buy |
| SEVEN GRAND MANAGERS, LLC |
| 0.01% | — | #7 | $138,800 | 10,000 | $0 | 0 | +10,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #16 | $21,431 | 1,544 | $0 | 0 | +1,544 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | — | #14 | $9,966 | 718 | $0 | 0 | +718 | New Buy |
| UBS Group AG |
| <0.01% | — | #17 | $8,842 | 637 | $0 | 0 | +637 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #19 | $1,749 | 126 | $0 | 0 | +126 | New Buy |
| Pioneer Family Office, LLC |
| <0.01% | — | #8 | $1,332 | 96 | $0 | 0 | +96 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | — | #20 | $1,000 | 98 | $0 | 0 | +98 | New Buy |
| Altshuler Shaham Ltd |
| <0.01% | — | #15 | $347 | 25 | $0 | 0 | +25 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #21 | $167 | 12 | $0 | 0 | +12 | New Buy |
| Towne Trust Company, N.A |
| <0.01% | — | #11 | $69 | 5 | $0 | 0 | +5 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #22 | $56 | 4 | $0 | 0 | +4 | New Buy |
| Activest Wealth Management |
| <0.01% | — | #12 | $56 | 4 | $0 | 0 | +4 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | — | #18 | $28 | 2 | $0 | 0 | +2 | New Buy |
| Point Nemo Capital, LLC |
| <0.01% | — | #13 | $14 | 1 | $0 | 0 | +1 | New Buy |
