| AIGH Capital Management LLC |
| 0.96% | 1.5% | #2 | $15.3M | 678,328 | $11.0M | 758,328 | -80,000-10.55% | Reduce |
| Soleus Capital Management, L.P. |
| 0.46% | 0.24% | #6 | $13.2M | 585,958 | $6.0M | 416,599 | +169,359+40.65% | Add |
| Telemark Asset Management, LLC |
| 0.8% | 0.66% | #3 | $11.0M | 489,824 | $7.1M | 489,824 | 00.00% | Unchanged |
| Aberdeen Group plc |
| 0.01% | 0.01% | #13 | $8.8M | 388,639 | $6.6M | 458,438 | -69,799-15.23% | Reduce |
| Birchview Capital, LP |
| 2.92% | 2.37% | #1 | $6.5M | 286,804 | $4.2M | 286,804 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $6.4M | 284,169 | $3.7M | 255,161 | +29,008+11.37% | Add |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.71% | 0.3% | #5 | $5.5M | 241,915 | $1.9M | 132,086 | +109,829+83.15% | Add |
| Opaleye Management Inc. |
| 0.37% | 0.45% | #7 | $4.1M | 180,000 | $3.5M | 238,047 | -58,047-24.38% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #21 | $2.6M | 116,199 | $2.1M | 141,636 | -25,437-17.96% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.04% | — | #12 | $2.5M | 108,694 | $0 | 0 | +108,694 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #29 | $2.1M | 91,506 | $391,950 | 27,031 | +64,475+238.52% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #22 | $2.0M | 86,824 | $655,850 | 45,231 | +41,593+91.96% | Add |
| Legato Capital Management LLC |
| 0.15% | — | #10 | $1.8M | 81,381 | $0 | 0 | +81,381 | New Buy |
| Walleye Capital LLC |
| 0.01% | <0.01% | #16 | $1.7M | 74,447 | $157,180 | 10,840 | +63,607+586.78% | Add |
| STEMPOINT CAPITAL LP |
| 0.22% | 0.19% | #8 | $1.6M | 70,000 | $1.0M | 70,004 | -4-0.01% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $1.5M | 67,657 | $725,594 | 49,998 | +17,659+35.32% | Add |
| Trexquant Investment LP |
| 0.01% | 0.01% | #15 | $1.3M | 57,972 | $1.0M | 69,601 | -11,629-16.71% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| 0.07% | 0.04% | #11 | $1.1M | 46,989 | $571,000 | 39,406 | +7,583+19.24% | Add |
| PERKINS CAPITAL MANAGEMENT INC |
| 0.79% | 0.61% | #4 | $1.0M | 44,618 | $649,353 | 44,783 | -165-0.37% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #37 | $970,236 | 43,026 | $354,757 | 24,466 | +18,560+75.86% | Add |
| BLAIR WILLIAM & CO/IL |
| <0.01% | <0.01% | #19 | $936,907 | 41,548 | $399,954 | 27,583 | +13,965+50.63% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #28 | $901,075 | 39,959 | $415,570 | 28,660 | +11,299+39.42% | Add |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #25 | $841,002 | 37,295 | $623,848 | 43,024 | -5,729-13.32% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $674,426 | 29,908 | $533,717 | 36,808 | -6,900-18.75% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $646,012 | 28,648 | $173,246 | 11,948 | +16,700+139.77% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | — | #35 | $602,942 | 26,738 | $0 | 0 | +26,738 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #14 | $587,089 | 26,035 | $160,008 | 11,035 | +15,000+135.93% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #17 | $558,473 | 24,766 | $0 | 0 | +24,766 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #38 | $401,435 | 17,802 | $258,129 | 17,802 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | — | #27 | $354,238 | 15,709 | $0 | 0 | +15,709 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $324,810 | 14,404 | $348,087 | 24,006 | -9,602-40.00% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | — | #36 | $312,520 | 13,859 | $0 | 0 | +13,859 | New Buy |
| THOMPSON DAVIS & CO., INC. |
| 0.15% | 0.11% | #9 | $255,943 | 11,350 | $170,375 | 11,750 | -400-3.40% | Reduce |
| Cannell & Spears LLC |
| <0.01% | — | #18 | $201,169 | 8,921 | $0 | 0 | +8,921 | New Buy |
| Allworth Financial LP |
| <0.01% | <0.01% | #26 | $111,961 | 4,965 | $71,993 | 4,965 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #39 | $23,768 | 1,054 | $15,283 | 1,054 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #40 | $7,058 | 313 | $0 | 0 | +313 | New Buy |
| Pflug Koory, LLC |
| <0.01% | — | #20 | $5,638 | 250 | $0 | 0 | +250 | New Buy |
| Fortitude Family Office, LLC |
| <0.01% | <0.01% | #24 | $3,856 | 171 | $2,480 | 171 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #41 | $2,661 | 118 | $13,398 | 924 | -806-87.23% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #44 | $2,147 | 95 | $15 | 1 | +94+9,400.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #45 | $1,376 | 61 | $574 | 76 | -15-19.74% | Reduce |
| CITIGROUP INC |
| <0.01% | — | #43 | $1,308 | 58 | $0 | 0 | +58 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #46 | $1,024 | 43 | $0 | 0 | +43 | New Buy |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #42 | $767 | 34 | $0 | 0 | +34 | New Buy |
| GILL CAPITAL PARTNERS, LLC |
| <0.01% | <0.01% | #33 | $293 | 13 | $189 | 13 | 00.00% | Unchanged |
