| Ikarian Capital, LLC |
| 0.05% | 0.2% | #2 | $461,284 | 288,303 | $2.5M | 238,303 | +50,000+20.98% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #11 | $443,523 | 277,202 | $0 | 0 | +277,202 | New Buy |
| Sofinnova Investments, Inc. |
| 0.02% | 0.09% | #5 | $356,246 | 222,654 | $2.4M | 222,654 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #13 | $273,923 | 171,202 | $646,503 | 60,534 | +110,668+182.82% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #20 | $250,947 | 156,842 | $0 | 0 | +156,842 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #16 | $140,979 | 88,112 | $0 | 0 | +88,112 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | 0.01% | #8 | $135,499 | 84,687 | $743,510 | 69,617 | +15,070+21.65% | Add |
| Squadron Capital Management LLC |
| 0.03% | 1.04% | #4 | $103,142 | 64,464 | $2.8M | 265,000 | -200,536-75.67% | Reduce |
| Verdad Advisers, LP |
| 0.09% | 0.52% | #1 | $96,722 | 60,451 | $458,759 | 42,955 | +17,496+40.73% | Add |
| PFIZER INC |
| 0.04% | 0.64% | #3 | $72,967 | 44,347 | $1.5M | 153,354 | -109,007-71.08% | Reduce |
| Affinity Asset Advisors, LLC |
| <0.01% | 0.13% | #6 | $67,136 | 41,960 | $2.6M | 241,826 | -199,866-82.65% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #24 | $59,757 | 37,348 | $296,830 | 27,793 | +9,555+34.38% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #14 | $58,320 | 36,450 | $0 | 0 | +36,450 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #21 | $52,360 | 32,725 | $0 | 0 | +32,725 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $47,855 | 29,905 | $327,136 | 31,092 | -1,187-3.82% | Reduce |
| CARDIFF PARK ADVISORS, LLC |
| <0.01% | 0.02% | #7 | $34,933 | 21,833 | $233,176 | 21,833 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $30,371 | 18,982 | $199,000 | 18,982 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #19 | $25,814 | 16,134 | $0 | 0 | +16,134 | New Buy |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #18 | $20,000 | 12,500 | $0 | 0 | +12,500 | New Buy |
| Virtu Financial LLC |
| <0.01% | — | #12 | $17,586 | 10,991 | $0 | 0 | +10,991 | New Buy |
| DIADEMA PARTNERS LP |
| <0.01% | — | #9 | $12,387 | 7,742 | $0 | 0 | +7,742 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #23 | $9,162 | 5,726 | $60,085 | 5,626 | +100+1.78% | Add |
| Persistent Asset Partners Ltd |
| <0.01% | — | #10 | $3,170 | 1,981 | $0 | 0 | +1,981 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #15 | $2,781 | 1,738 | $0 | 0 | +1,738 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #26 | $951 | 594 | $3,610 | 338 | +256+75.74% | Add |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | — | #27 | $133 | 83 | $0 | 0 | +83 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #29 | $107 | 61 | $587 | 61 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | — | #29 | $106 | 66 | $0 | 0 | +66 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #28 | $51 | 32 | $342 | 32 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | — | #25 | $32 | 20 | $0 | 0 | +20 | New Buy |
