| Stonepine Capital Management, LLC |
| 0.17% | 0.25% | #2 | $1.1M | 2.2M | $616,659 | 831,301 | +1.4M+164.82% | Add |
| Jupiter Topco LLC |
| <0.01% | — | #11 | $1.1M | 2.1M | $0 | 0 | +2.1M | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #9 | $1.1M | 2.1M | $1.6M | 2.1M | 00.00% | Unchanged |
| Opaleye Management Inc. |
| 0.1% | — | #4 | $1.1M | 2.1M | $0 | 0 | +2.1M | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #12 | $960,955 | 1.9M | $1.0M | 1.4M | +513,589+38.02% | Add |
| Cable Car Capital, LP |
| 0.29% | 0.3% | #1 | $894,892 | 1.2M | $894,892 | 1.2M | 00.00% | Unchanged |
| Squadron Capital Management LLC |
| 0.16% | 0.57% | #3 | $515,400 | 1.0M | $1.6M | 2.1M | -1.1M-52.38% | Reduce |
| AdvisorShares Investments LLC |
| 0.06% | 0.05% | #5 | $483,213 | 937,550 | $250,363 | 337,508 | +600,042+177.79% | Add |
| Vivo Capital, LLC |
| 0.02% | 0.13% | #7 | $239,904 | 465,471 | $1.6M | 2.1M | -1.6M-77.83% | Reduce |
| Persistent Asset Partners Ltd |
| 0.05% | 0.08% | #6 | $149,752 | 290,555 | $215,534 | 290,555 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #18 | $96,877 | 188,111 | $19,402 | 26,149 | +161,962+619.38% | Add |
| XTX Topco Ltd |
| <0.01% | <0.01% | #10 | $65,751 | 127,572 | $25,036 | 33,751 | +93,821+277.98% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #22 | $65,034 | 126,279 | $39,931 | 53,815 | +72,464+134.65% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $43,221 | 83,856 | $77,138 | 103,985 | -20,129-19.36% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $33,810 | 65,600 | $69,283 | 93,399 | -27,799-29.76% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #16 | $33,071 | 64,166 | $15,618 | 21,054 | +43,112+204.77% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #19 | $22,588 | 43,860 | $32,544 | 43,860 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #21 | $16,186 | 31,405 | $14,370 | 19,372 | +12,033+62.12% | Add |
| Jump Financial, LLC |
| <0.01% | — | #13 | $15,133 | 29,363 | $0 | 0 | +29,363 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #14 | $4,555 | 8,838 | $1,375 | 1,854 | +6,984+376.70% | Add |
| Hurley Capital, LLC |
| <0.01% | <0.01% | #8 | $3,608 | 7,000 | $2,737 | 3,689 | +3,311+89.75% | Add |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #17 | $542 | 1,051 | $780 | 1,051 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #23 | $139 | 269 | $0 | 0 | +269 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #24 | $79 | 150 | $107 | 150 | 00.00% | Unchanged |
