| PERCEPTIVE ADVISORS LLC |
| 0.26% | 0.37% | #7 | $17.1M | 1.9M | $19.1M | 1.9M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.33% | 0.44% | #5 | $7.1M | 777,100 | $7.5M | 727,481 | +49,619+6.82% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 1.59% | 1.85% | #2 | $5.8M | 634,539 | $6.5M | 634,539 | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 0.27% | 0.27% | #6 | $4.3M | 464,398 | $4.8M | 464,398 | 00.00% | Unchanged |
| Commodore Capital LP |
| 0.25% | 0.28% | #8 | $4.3M | 464,398 | $4.8M | 464,398 | 00.00% | Unchanged |
| TCG Crossover Management, LLC |
| 0.1% | 0.13% | #10 | $4.3M | 464,398 | $4.7M | 464,398 | 00.00% | Unchanged |
| Spruce Street Capital LP |
| 0.71% | 0.92% | #4 | $3.6M | 393,701 | $3.8M | 393,701 | 00.00% | Unchanged |
| Kalehua Capital Management LLC |
| 2.59% | 2.86% | #1 | $3.6M | 393,701 | $4.0M | 393,701 | 00.00% | Unchanged |
| Blackstone Inc. |
| 0.01% | — | #12 | $3.0M | 324,638 | $0 | 0 | +324,638 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #13 | $2.8M | 300,000 | $0 | 0 | +300,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $2.5M | 275,233 | $2.0M | 194,760 | +80,473+41.32% | Add |
| Seven Fleet Capital Management LP |
| 0.23% | 0.54% | #9 | $1.4M | 154,153 | $1.7M | 164,676 | -10,523-6.39% | Reduce |
| Simplify Asset Management Inc. |
| 0.02% | 0.02% | #11 | $1.4M | 149,279 | $1.5M | 149,279 | 00.00% | Unchanged |
| Propel Bio Management, LLC |
| 0.72% | 0.94% | #3 | $1.4M | 149,279 | $1.5M | 149,279 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $739,513 | 80,418 | $826,214 | 80,323 | +95+0.12% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $727,719 | 79,186 | $576,204 | 56,051 | +23,135+41.27% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #16 | $711,527 | 77,424 | $660,202 | 64,222 | +13,202+20.56% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #22 | $393,461 | 42,814 | $411,601 | 40,039 | +2,775+6.93% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #28 | $299,199 | 32,557 | $334,778 | 32,566 | -9-0.03% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $298,216 | 32,450 | $325,650 | 31,678 | +772+2.44% | Add |
| Laird Norton Wetherby Trust Company, LLC |
| <0.01% | <0.01% | #14 | $200,508 | 21,818 | $224,289 | 21,818 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #35 | $150,137 | 16,337 | $167,944 | 16,337 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #27 | $135,351 | 14,728 | $0 | 0 | +14,728 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $132,281 | 14,394 | $147,970 | 14,394 | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $122,006 | 13,276 | $136,477 | 13,276 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #15 | $107,973 | 11,749 | $0 | 0 | +11,749 | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $94,014 | 10,230 | $105,000 | 10,230 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | — | #31 | $91,909 | 10,001 | $0 | 0 | +10,001 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #25 | $42,090 | 4,580 | $63,530 | 6,180 | -1,600-25.89% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #38 | $17,826 | 2,012 | $111 | 12 | +2,000+16,666.67% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #34 | $12,177 | 1,325 | $13,621 | 1,325 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #37 | $8,000 | 844 | $23,000 | 2,225 | -1,381-62.07% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $4,025 | 438 | $0 | 0 | +438 | New Buy |
| American Capital Advisory, LLC |
| <0.01% | <0.01% | #17 | $1,838 | 200 | $2,056 | 200 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #40 | $1,802 | 196 | $13,353 | 1,299 | -1,103-84.91% | Reduce |
| ROTHSCHILD INVESTMENT LLC |
| <0.01% | <0.01% | #24 | $1,379 | 150 | $1,542 | 150 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #44 | $818 | 89 | $2,112 | 510 | -421-82.55% | Reduce |
| US BANCORP \DE\ |
| <0.01% | <0.01% | #39 | $744 | 81 | $833 | 81 | 00.00% | Unchanged |
| Global Retirement Partners, LLC |
| <0.01% | — | #33 | $477 | 52 | $0 | 0 | +52 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #43 | $386 | 42 | $0 | 0 | +42 | New Buy |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #41 | $310 | 33 | $296 | 33 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #42 | $184 | 20 | $236 | 23 | -3-13.04% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #36 | $110 | 12 | $123 | 12 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #32 | $55 | 6 | $62 | 6 | 00.00% | Unchanged |
