| BAKER BROS. ADVISORS LP |
| 5.77% | 6.44% | #5 | $1.15B | 2.1M | $1.12B | 2.1M | +1,430+0.07% | Add |
| RTW INVESTMENTS, LP |
| 9.14% | 10.38% | #2 | $1.07B | 2.0M | $1.04B | 2.0M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.42% | — | #30 | $1.04B | 1.9M | $0 | 0 | +1.9M | New Buy |
| Avoro Capital Advisors LLC |
| 8.84% | 9.36% | #3 | $984.4M | 1.8M | $951.8M | 1.8M | +15,152+0.83% | Add |
| PAULSON & CO. INC. |
| 27.94% | 23.42% | #1 | $719.5M | 1.3M | $728.8M | 1.4M | -52,168-3.75% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #183 | $644.8M | 1.2M | $816.6M | 1.6M | -359,195-23.03% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #182 | $448.7M | 835,668 | $433.0M | 827,144 | +8,524+1.03% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.08% | 0.07% | #78 | $443.4M | 825,714 | $363.8M | 694,958 | +130,756+18.81% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #142 | $419.8M | 781,731 | $440.3M | 841,145 | -59,414-7.06% | Reduce |
| CITADEL ADVISORS LLC |
| 0.04% | 0.05% | #104 | $369.5M | 688,133 | $315.4M | 602,543 | +85,590+14.20% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #195 | $283.0M | 527,057 | $319.1M | 609,525 | -82,468-13.53% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.01% | #143 | $240.0M | 446,910 | $126.0M | 240,616 | +206,294+85.74% | Add |
| UBS Group AG |
| 0.03% | 0.01% | #121 | $215.7M | 401,708 | $61.7M | 117,779 | +283,929+241.07% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #173 | $201.3M | 374,880 | $238.7M | 455,870 | -80,990-17.77% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #197 | $191.3M | 356,201 | $267.9M | 511,728 | -155,527-30.39% | Reduce |
| JANE STREET GROUP, LLC |
| 0.02% | 0.02% | #149 | $190.5M | 354,841 | $125.2M | 239,238 | +115,603+48.32% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.52% | 0.59% | #24 | $174.0M | 324,123 | $178.3M | 340,519 | -16,396-4.82% | Reduce |
| Invesco Ltd. |
| 0.01% | 0.03% | #159 | $161.9M | 301,435 | $172.5M | 329,519 | -28,084-8.52% | Reduce |
| ARMISTICE CAPITAL, LLC |
| 1.89% | 2.46% | #13 | $154.6M | 288,000 | $138.5M | 264,583 | +23,417+8.85% | Add |
| LORD, ABBETT & CO. LLC |
| 0.43% | 0.41% | #29 | $151.2M | 281,500 | $127.1M | 242,726 | +38,774+15.97% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #168 | $132.2M | 246,280 | $145.2M | 277,371 | -31,091-11.21% | Reduce |
| Polar Capital Holdings Plc |
| 0.31% | 0.54% | #36 | $131.2M | 244,274 | $151.4M | 289,310 | -45,036-15.57% | Reduce |
| AMERIPRISE FINANCIAL INC |
| 0.03% | 0.01% | #126 | $124.1M | 231,205 | $51.4M | 98,181 | +133,024+135.49% | Add |
| NORGES BANK |
| 0.01% | <0.01% | #169 | $114.8M | 213,886 | $31.1M | 93,997 | +119,889+127.55% | Add |
| Artisan Partners Limited Partnership |
| 0.18% | 0.15% | #53 | $112.9M | 210,205 | $96.1M | 183,540 | +26,665+14.53% | Add |
| Pictet Asset Management Holding SA |
| 0.1% | 0.1% | #70 | $103.5M | 192,896 | $97.9M | 187,240 | +5,656+3.02% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #179 | $100.5M | 187,226 | $171.8M | 328,110 | -140,884-42.94% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #116 | $99.2M | 189,458 | $73.1M | 125,447 | +64,011+51.03% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.02% | #156 | $99.0M | 184,324 | $113.4M | 216,720 | -32,396-14.95% | Reduce |
| Caption Management, LLC |
| 0.46% | 0.43% | #26 | $98.4M | 183,200 | $73.3M | 140,000 | +43,200+30.86% | Add |
| TORONTO DOMINION BANK |
| 0.11% | 0.1% | #66 | $97.4M | 181,432 | $68.3M | 130,460 | +50,972+39.07% | Add |
| Rock Springs Capital Management LP |
| 4.59% | 5.28% | #7 | $94.0M | 174,999 | $89.5M | 170,999 | +4,000+2.34% | Add |
| Hood River Capital Management LLC |
| 0.66% | 1.31% | #21 | $90.8M | 169,084 | $130.6M | 249,511 | -80,427-32.23% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.04% | 0.04% | #106 | $87.1M | 162,271 | $66.7M | 127,339 | +34,932+27.43% | Add |
| Holocene Advisors, LP |
| 0.19% | — | #52 | $82.1M | 152,924 | $0 | 0 | +152,924 | New Buy |
| Point72 Asset Management, L.P. |
| 0.08% | 0.16% | #75 | $76.6M | 142,629 | $123.0M | 234,910 | -92,281-39.28% | Reduce |
| MORGAN STANLEY |
| <0.01% | 0.01% | #255 | $74.6M | 139,009 | $114.5M | 249,647 | -110,638-44.32% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #243 | $72.0M | 134,036 | $99.2M | 189,527 | -55,491-29.28% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #171 | $69.0M | 128,520 | $71.1M | 135,908 | -7,388-5.44% | Reduce |
| Woodline Partners LP |
| 0.21% | 0.25% | #46 | $67.6M | 125,899 | $65.9M | 125,899 | 00.00% | Unchanged |
| Assenagon Asset Management S.A. |
| 0.08% | 0.01% | #76 | $66.7M | 124,214 | $8.4M | 16,033 | +108,181+674.74% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.02% | #153 | $65.3M | 121,583 | $67.0M | 128,079 | -6,496-5.07% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #137 | $63.6M | 118,496 | $21.4M | 40,853 | +77,643+190.05% | Add |
| Clearbridge Investments, LLC |
| 0.05% | 0.01% | #100 | $58.7M | 109,325 | $12.8M | 24,447 | +84,878+347.19% | Add |
| Erste Asset Management GmbH |
| 0.45% | 0.75% | #27 | $58.1M | 110,210 | $81.0M | 160,210 | -50,000-31.21% | Reduce |
| MARSHALL WACE, LLP |
| 0.04% | 0.01% | #103 | $54.7M | 101,859 | $11.5M | 21,902 | +79,957+365.07% | Add |
| Fiera Capital Corp |
| 0.19% | 0.31% | #50 | $53.6M | 99,857 | $91.1M | 174,011 | -74,154-42.61% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.04% | #130 | $53.4M | 99,396 | $85.8M | 163,933 | -64,537-39.37% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #223 | $52.9M | 98,510 | $78.1M | 149,214 | -50,704-33.98% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| 0.06% | 0.05% | #85 | $50.9M | 94,743 | $39.3M | 75,129 | +19,614+26.11% | Add |
