| BlackRock, Inc. |
| 0.01% | 0.01% | #276 | $759.7M | 3.1M | $661.3M | 3.9M | -809,136-20.68% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #224 | $485.5M | 2.0M | $347.9M | 2.1M | -74,656-3.63% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #291 | $481.0M | 2.0M | $327.5M | 1.9M | +27,334+1.41% | Add |
| Invesco Ltd. |
| 0.03% | 0.03% | #197 | $409.2M | 1.7M | $219.3M | 1.3M | +374,006+28.82% | Add |
| FMR LLC |
| 0.02% | 0.01% | #247 | $376.7M | 1.5M | $264.9M | 1.6M | -27,832-1.78% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #267 | $236.8M | 967,172 | $196.6M | 1.2M | -195,809-16.84% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.01% | #246 | $222.1M | 907,415 | $75.1M | 444,598 | +462,817+104.10% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #285 | $196.8M | 804,082 | $49.7M | 409,580 | +394,502+96.32% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #336 | $192.3M | 785,661 | $166.8M | 986,809 | -201,148-20.38% | Reduce |
| JANE STREET GROUP, LLC |
| 0.02% | <0.01% | #253 | $183.5M | 749,795 | $33.2M | 196,278 | +553,517+282.01% | Add |
| Deep Track Capital, LP |
| 2.49% | 3.04% | #14 | $171.3M | 700,000 | $185.9M | 1.1M | -400,000-36.36% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.12% | 0.04% | #111 | $166.4M | 679,978 | $55.2M | 326,478 | +353,500+108.28% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.02% | #193 | $163.6M | 668,373 | $74.1M | 438,490 | +229,883+52.43% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.04% | #207 | $160.1M | 653,920 | $193.6M | 1.1M | -491,386-42.90% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.08% | 0.06% | #138 | $159.9M | 653,353 | $102.6M | 607,165 | +46,188+7.61% | Add |
| ALETHEA CAPITAL MANAGEMENT, LLC |
| 65.78% | 56.28% | #1 | $158.8M | 648,756 | $109.7M | 649,114 | -358-0.06% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.03% | #252 | $157.4M | 642,893 | $222.6M | 1.3M | -674,166-51.19% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| 0.05% | <0.01% | #171 | $139.8M | 571,288 | $8.6M | 50,858 | +520,430+1,023.30% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.2% | 0.24% | #77 | $132.0M | 539,407 | $137.4M | 812,809 | -273,402-33.64% | Reduce |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #259 | $126.1M | 515,178 | $71.2M | 421,003 | +94,175+22.37% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #268 | $125.9M | 514,266 | $51.0M | 437,497 | +76,769+17.55% | Add |
| FIRST TRUST ADVISORS LP |
| 0.07% | 0.07% | #150 | $118.0M | 482,061 | $97.6M | 577,479 | -95,418-16.52% | Reduce |
| Point72 Asset Management, L.P. |
| 0.13% | 0.09% | #101 | $117.4M | 479,816 | $71.8M | 424,750 | +55,066+12.96% | Add |
| Assenagon Asset Management S.A. |
| 0.14% | 0.22% | #95 | $111.3M | 454,682 | $146.4M | 865,958 | -411,276-47.49% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #320 | $110.8M | 452,491 | $101.1M | 598,091 | -145,600-24.34% | Reduce |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.01% | #227 | $104.8M | 428,079 | $29.8M | 176,314 | +251,765+142.79% | Add |
| Pictet Asset Management Holding SA |
| 0.1% | 0.07% | #122 | $104.4M | 426,527 | $70.3M | 415,983 | +10,544+2.53% | Add |
| Qube Research & Technologies Ltd |
| 0.1% | 0.06% | #125 | $104.4M | 426,336 | $56.7M | 335,334 | +91,002+27.14% | Add |
| Hood River Capital Management LLC |
| 0.71% | 0.63% | #36 | $98.6M | 402,678 | $62.8M | 371,503 | +31,175+8.39% | Add |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.13% | 0.03% | #103 | $91.3M | 373,067 | $16.5M | 97,550 | +275,517+282.44% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.53% | 0.36% | #47 | $91.2M | 372,474 | $49.4M | 292,370 | +80,104+27.40% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.04% | 0.03% | #181 | $81.4M | 332,642 | $59.2M | 350,488 | -17,846-5.09% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.04% | 1.45% | #29 | $77.5M | 316,820 | $87.8M | 519,558 | -202,738-39.02% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #289 | $77.4M | 316,104 | $66.8M | 395,118 | -79,014-20.00% | Reduce |
| Integral Health Asset Management, LLC |
| 2.9% | 0.28% | #12 | $73.4M | 300,000 | $5.9M | 35,000 | +265,000+757.14% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #254 | $68.5M | 279,738 | $49.9M | 295,139 | -15,401-5.22% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #312 | $66.1M | 270,189 | $67.9M | 401,459 | -131,270-32.70% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.09% | 0.04% | #130 | $64.1M | 262,000 | $27.8M | 164,300 | +97,700+59.46% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.09% | 0.19% | #128 | $63.4M | 259,034 | $124.7M | 737,578 | -478,544-64.88% | Reduce |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.58% | 0.35% | #40 | $62.2M | 254,280 | $34.3M | 203,066 | +51,214+25.22% | Add |
| SAMLYN CAPITAL, LLC |
| 0.98% | — | #31 | $60.2M | 246,015 | $0 | 0 | +246,015 | New Buy |
| Clearbridge Investments, LLC |
| 0.05% | 0.01% | #167 | $60.1M | 245,574 | $7.6M | 45,020 | +200,554+445.48% | Add |
| LOOMIS SAYLES & CO L P |
| 0.07% | 0.06% | #141 | $58.6M | 239,490 | $43.4M | 256,625 | -17,135-6.68% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.02% | #208 | $56.5M | 230,954 | $31.8M | 188,146 | +42,808+22.75% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #346 | $56.2M | 229,668 | $71.2M | 421,447 | -191,779-45.50% | Reduce |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.03% | 0.01% | #202 | $55.2M | 225,400 | $15.4M | 91,400 | +134,000+146.61% | Add |
| MARSHALL WACE, LLP |
| 0.04% | 0.02% | #176 | $54.7M | 223,386 | $23.9M | 141,236 | +82,150+58.17% | Add |
| PFM Health Sciences, LP |
| 4.61% | 4.07% | #6 | $53.8M | 219,596 | $44.7M | 264,304 | -44,708-16.92% | Reduce |
| Tri Locum Partners LP |
| 6.6% | 1.47% | #3 | $53.7M | 219,308 | $10.5M | 62,116 | +157,192+253.06% | Add |
| First Turn Management, LLC |
| 5.72% | 3.56% | #4 | $53.5M | 218,415 | $31.9M | 188,772 | +29,643+15.70% | Add |
