| BlackRock, Inc. |
| 0.01% | 0.01% | #221 | $757.0M | 9.6M | $774.1M | 9.6M | +77,945+0.81% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.18% | 0.17% | #49 | $537.4M | 6.6M | $539.1M | 9.2M | -2.5M-27.68% | Reduce |
| Artal Group S.A. |
| 54.85% | 76.11% | #1 | $510.7M | 6.5M | $769.2M | 9.5M | -3.0M-31.55% | Reduce |
| FMR LLC |
| 0.02% | 0.03% | #174 | $433.9M | 5.5M | $478.3M | 5.9M | -383,015-6.48% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #273 | $352.1M | 4.5M | $359.6M | 4.4M | +40,711+0.92% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.02% | #195 | $330.7M | 4.2M | $339.2M | 4.2M | +20,526+0.49% | Add |
| JANE STREET GROUP, LLC |
| 0.02% | 0.02% | #155 | $270.6M | 3.4M | $179.3M | 2.2M | +1.2M+55.63% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.03% | #169 | $256.1M | 3.3M | $231.7M | 2.9M | +398,727+13.92% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #279 | $243.2M | 3.1M | $243.2M | 3.0M | +92,626+3.08% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.03% | #152 | $238.1M | 3.0M | $296.5M | 3.7M | -631,239-17.22% | Reduce |
| 1832 Asset Management L.P. |
| 0.1% | 0.11% | #69 | $198.2M | 2.5M | $122.9M | 1.5M | +1.0M+66.24% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #252 | $166.9M | 2.1M | $150.0M | 2.5M | -356,110-14.34% | Reduce |
| Capital International Investors |
| 0.03% | 0.05% | #127 | $161.5M | 2.1M | $211.2M | 2.6M | -551,807-21.14% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #259 | $157.3M | 2.0M | $162.0M | 2.0M | +1,734+0.09% | Add |
| CITADEL ADVISORS LLC |
| 0.02% | 0.04% | #180 | $149.2M | 1.9M | $217.3M | 2.7M | -784,875-29.22% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #158 | $126.0M | 1.6M | $73.4M | 907,809 | +697,699+76.86% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #229 | $118.9M | 1.5M | $86.7M | 1.1M | +444,050+41.46% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.02% | #154 | $115.6M | 1.5M | $65.5M | 810,207 | +662,999+81.83% | Add |
| Capital Research Global Investors |
| 0.02% | 0.08% | #188 | $113.4M | 1.4M | $496.5M | 6.1M | -4.7M-76.47% | Reduce |
| Clearbridge Investments, LLC |
| 0.09% | 0.1% | #73 | $110.4M | 1.4M | $116.8M | 1.4M | -37,252-2.58% | Reduce |
| Hood River Capital Management LLC |
| 0.8% | 0.96% | #17 | $110.4M | 1.4M | $95.4M | 1.2M | +226,808+19.23% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #228 | $104.3M | 1.3M | $57.2M | 662,361 | +666,367+100.60% | Add |
| CITIGROUP INC |
| 0.03% | 0.04% | #132 | $97.7M | 1.2M | $101.4M | 1.3M | -7,876-0.63% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.04% | 0.02% | #111 | $93.6M | 1.2M | $26.1M | 323,100 | +869,823+269.21% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.05% | 0.08% | #94 | $93.0M | 1.2M | $102.0M | 1.3M | -75,800-6.01% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.07% | 0.02% | #84 | $92.9M | 1.2M | $22.0M | 272,442 | +911,200+334.46% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.27% | 0.64% | #33 | $89.9M | 1.1M | $193.7M | 2.4M | -1.2M-52.17% | Reduce |
| Prime Capital Management Co Ltd |
| 6.47% | 9.37% | #3 | $81.0M | 1.0M | $83.5M | 1.0M | 00.00% | Unchanged |
| Capital World Investors |
| 0.01% | 0.02% | #242 | $80.2M | 1.0M | $172.1M | 2.1M | -1.1M-51.96% | Reduce |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.45% | 0.5% | #22 | $78.2M | 996,496 | $68.5M | 846,738 | +149,758+17.69% | Add |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #193 | $74.3M | 946,829 | $83.3M | 1.0M | -83,144-8.07% | Reduce |
| Liontrust Investment Partners LLP |
| 1.05% | 1.21% | #10 | $71.5M | 911,654 | $69.3M | 856,057 | +55,597+6.49% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.06% | 0.04% | #86 | $70.5M | 898,048 | $37.9M | 468,444 | +429,604+91.71% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.03% | 0.03% | #125 | $69.5M | 885,112 | $56.0M | 692,260 | +192,852+27.86% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #212 | $69.1M | 880,853 | $62.9M | 778,093 | +102,760+13.21% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #250 | $68.0M | 866,060 | $65.8M | 812,857 | +53,203+6.55% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #274 | $64.4M | 820,026 | $66.1M | 816,981 | +3,045+0.37% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.02% | #166 | $60.2M | 767,601 | $55.7M | 689,070 | +78,531+11.40% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | <0.01% | #140 | $58.8M | 655,620 | $1.8M | 21,947 | +633,673+2,887.29% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.07% | 0.07% | #82 | $58.4M | 744,629 | $56.4M | 697,762 | +46,867+6.72% | Add |
| RAYMOND JAMES FINANCIAL INC |
| 0.02% | 0.02% | #192 | $56.7M | 722,476 | $62.3M | 802,857 | -80,381-10.01% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.16% | 0.14% | #53 | $56.5M | 719,356 | $42.7M | 527,948 | +191,408+36.26% | Add |
| Champlain Investment Partners, LLC |
| 1.41% | 1.43% | #7 | $55.0M | 701,117 | $113.0M | 1.4M | -696,264-49.83% | Reduce |
| Allspring Global Investments Holdings, LLC |
| 0.08% | 0.09% | #75 | $54.5M | 682,636 | $55.1M | 687,587 | -4,951-0.72% | Reduce |
| Walleye Trading LLC |
| 0.06% | 0.09% | #87 | $52.7M | 671,900 | $51.0M | 631,000 | +40,900+6.48% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #346 | $51.4M | 655,326 | $105.0M | 1.3M | -642,035-49.49% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #222 | $50.7M | 646,209 | $51.2M | 633,299 | +12,910+2.04% | Add |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #268 | $48.5M | 618,545 | $52.4M | 647,718 | -29,173-4.50% | Reduce |
| UBS Group AG |
| 0.01% | 0.02% | #291 | $47.3M | 603,334 | $106.0M | 1.3M | -706,343-53.93% | Reduce |
| Squarepoint Ops LLC |
| 0.05% | 0.04% | #104 | $42.8M | 544,927 | $36.6M | 452,100 | +92,827+20.53% | Add |
