| FMR LLC |
| 0.12% | 0.11% | #73 | $2.87B | 81.0M | $2.16B | 78.0M | +3.0M+3.90% | Add |
| BlackRock, Inc. |
| 0.03% | 0.02% | #162 | $1.71B | 48.2M | $1.23B | 44.3M | +4.0M+9.00% | Add |
| MORGAN STANLEY |
| 0.08% | 0.04% | #96 | $1.51B | 42.6M | $670.6M | 44.3M | -1.7M-3.90% | Reduce |
| QVT Financial LP |
| 49.36% | 51.04% | #1 | $839.6M | 23.7M | $697.0M | 25.2M | -1.4M-5.72% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.02% | 0.01% | #206 | $782.9M | 22.1M | $572.9M | 20.7M | +1.4M+6.98% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.03% | #151 | $765.9M | 21.6M | $549.5M | 19.8M | +1.8M+9.09% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.06% | 0.04% | #116 | $656.7M | 18.6M | $307.8M | 11.1M | +7.4M+67.00% | Add |
| STATE STREET CORP |
| 0.02% | 0.02% | #190 | $629.8M | 17.8M | $448.4M | 16.2M | +1.6M+9.94% | Add |
| UBS Group AG |
| 0.08% | 0.09% | #98 | $618.1M | 17.5M | $626.6M | 22.6M | -5.2M-22.78% | Reduce |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 2.34% | 1.53% | #15 | $506.4M | 14.3M | $268.0M | 9.7M | +4.6M+47.90% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #172 | $425.5M | 11.7M | $282.1M | 10.2M | +1.5M+14.65% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.51% | 0.55% | #41 | $366.3M | 10.3M | $354.4M | 12.8M | -2.4M-19.11% | Reduce |
| Two Seas Capital LP |
| 6.98% | 3.9% | #5 | $352.4M | 10.0M | $278.7M | 10.1M | -102,635-1.02% | Reduce |
| WELLS FARGO & COMPANY/MN |
| 0.06% | <0.01% | #117 | $344.0M | 9.7M | $7.3M | 263,965 | +9.5M+3,582.81% | Add |
| Assenagon Asset Management S.A. |
| 0.37% | 0.3% | #45 | $296.0M | 8.4M | $196.0M | 7.1M | +1.3M+18.18% | Add |
| PERCEPTIVE ADVISORS LLC |
| 4.3% | 4.48% | #12 | $286.1M | 8.1M | $229.5M | 8.3M | -200,000-2.41% | Reduce |
| Patient Square Capital LP |
| 43.97% | 40.13% | #2 | $283.9M | 8.0M | $226.2M | 8.2M | -145,119-1.78% | Reduce |
| Invesco Ltd. |
| 0.02% | 0.03% | #178 | $266.5M | 7.5M | $178.4M | 6.4M | +1.1M+16.96% | Add |
| JANE STREET GROUP, LLC |
| 0.02% | <0.01% | #176 | $263.0M | 7.4M | $33.0M | 1.2M | +6.2M+524.07% | Add |
| Darwin Global Management, Ltd. |
| 6.23% | 4.76% | #6 | $234.3M | 6.7M | $179.5M | 6.8M | -50,000-0.74% | Reduce |
| AQR CAPITAL MANAGEMENT LLC |
| 0.08% | 0.07% | #93 | $234.0M | 6.6M | $161.6M | 5.9M | +686,702+11.55% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.63% | 0.52% | #35 | $221.9M | 6.3M | $184.3M | 6.7M | -380,981-5.73% | Reduce |
| Rubric Capital Management LP |
| 1.95% | 1.47% | #18 | $212.3M | 6.0M | $138.5M | 5.0M | +1.0M+20.00% | Add |
| CITADEL ADVISORS LLC |
| 0.02% | 0.01% | #166 | $205.7M | 5.8M | $75.4M | 2.7M | +3.1M+113.47% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.04% | #153 | $185.1M | 5.2M | $207.0M | 7.5M | -2.2M-30.04% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #204 | $170.5M | 4.8M | $193.7M | 7.0M | -2.2M-31.11% | Reduce |
| NORGES BANK |
| 0.02% | 0.01% | #205 | $168.0M | 4.7M | $46.2M | 4.6M | +165,652+3.62% | Add |
| BAKER BROS. ADVISORS LP |
| 0.84% | 0.77% | #29 | $166.9M | 4.7M | $134.8M | 4.9M | -150,892-3.10% | Reduce |
| Point72 Asset Management, L.P. |
| 0.18% | 0.03% | #63 | $159.1M | 4.5M | $27.0M | 975,000 | +3.5M+361.11% | Add |
| JENNISON ASSOCIATES LLC |
| 0.1% | 0.06% | #88 | $158.6M | 4.5M | $82.6M | 3.0M | +1.5M+50.26% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #244 | $153.6M | 4.3M | $87.6M | 3.2M | +1.2M+37.22% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.01% | #218 | $133.1M | 3.8M | $97.5M | 3.5M | +241,705+6.87% | Add |
| Affinity Asset Advisors, LLC |
| 6% | 4.01% | #7 | $132.7M | 3.8M | $77.6M | 2.8M | +950,000+33.93% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #198 | $131.5M | 3.7M | $95.8M | 3.5M | +258,146+7.47% | Add |
| Pictet Asset Management Holding SA |
| 0.12% | 0.08% | #75 | $122.7M | 3.5M | $74.0M | 2.7M | +795,107+29.74% | Add |
| Qube Research & Technologies Ltd |
| 0.11% | 0.11% | #78 | $122.3M | 3.5M | $95.6M | 3.5M | +3,592+0.10% | Add |
| Jupiter Topco LLC |
| 0.05% | — | #134 | $111.9M | 3.2M | $0 | 0 | +3.2M | New Buy |
| ADAR1 Capital Management, LLC |
| 5.15% | 5.36% | #9 | $111.7M | 3.2M | $91.0M | 3.3M | -128,898-3.92% | Reduce |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.08% | 0.02% | #92 | $105.7M | 3.0M | $19.4M | 699,137 | +2.3M+327.40% | Add |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #126 | $105.2M | 3.0M | $38.6M | 1.4M | +1.6M+113.44% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #174 | $102.6M | 2.9M | $77.9M | 2.8M | +89,412+3.18% | Add |
| MAVERICK CAPITAL LTD |
| 0.88% | 0.52% | #26 | $100.1M | 2.8M | $45.1M | 1.6M | +1.2M+73.89% | Add |
| Bank of New York Mellon Corp |
| 0.02% | 0.01% | #215 | $98.7M | 2.8M | $75.8M | 2.7M | +54,442+1.99% | Add |
| NATIONAL BANK OF CANADA /FI/ |
| 0.09% | 0.18% | #91 | $98.2M | 2.8M | $174.5M | 6.3M | -3.5M-55.96% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | <0.01% | #213 | $95.1M | 2.7M | $26.7M | 963,282 | +1.7M+179.03% | Add |
| Weiss Asset Management LP |
| 0.94% | — | #24 | $90.0M | 2.5M | $0 | 0 | +2.5M | New Buy |
| Woodline Partners LP |
| 0.27% | 0.18% | #51 | $88.5M | 2.5M | $48.5M | 1.8M | +750,656+42.89% | Add |
| HRT FINANCIAL LP |
| 0.16% | — | #67 | $87.2M | 2.5M | $0 | 0 | +2.5M | New Buy |
| CITIGROUP INC |
| 0.03% | 0.02% | #161 | $80.7M | 2.3M | $44.0M | 1.6M | +689,080+43.34% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #269 | $78.3M | 2.2M | $23.4M | 843,995 | +1.4M+162.06% | Add |
