| CITADEL ADVISORS LLC |
| <0.01% | — | #7 | $14.4M | 2.9M | $0 | 0 | +2.9M | New Buy |
| Lynx1 Capital Management LP |
| 0.65% | 0.77% | #1 | $3.3M | 673,759 | $4.9M | 623,704 | +50,055+8.03% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $556,144 | 113,964 | $894,617 | 113,964 | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #10 | $522,282 | 107,025 | $0 | 0 | +107,025 | New Buy |
| Ikarian Capital, LLC |
| 0.05% | 0.04% | #4 | $485,643 | 99,517 | $534,773 | 68,124 | +31,393+46.08% | Add |
| Yiheng Capital Management, L.P. |
| 0.16% | 0.29% | #2 | $420,153 | 86,097 | $675,861 | 86,097 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $233,713 | 47,892 | $1.0M | 133,612 | -85,720-64.16% | Reduce |
| Erste Asset Management GmbH |
| <0.01% | <0.01% | #8 | $197,225 | 40,665 | $526,919 | 85,262 | -44,597-52.31% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #18 | $180,716 | 37,026 | $324,878 | 41,380 | -4,354-10.52% | Reduce |
| Verdad Advisers, LP |
| 0.14% | 0.2% | #3 | $149,953 | 30,728 | $173,705 | 22,128 | +8,600+38.86% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #6 | $138,782 | 28,439 | $148,137 | 18,871 | +9,568+50.70% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #21 | $136,201 | 27,910 | $224,470 | 28,595 | -685-2.40% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #13 | $109,780 | 22,496 | $189,000 | 24,196 | -1,700-7.03% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #16 | $83,199 | 17,049 | $133,835 | 17,049 | 00.00% | Unchanged |
| DELTEC ASSET MANAGEMENT LLC |
| 0.01% | — | #5 | $73,200 | 15,000 | $0 | 0 | +15,000 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #19 | $66,197 | 13,565 | $215,883 | 27,501 | -13,936-50.67% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #14 | $62,035 | 12,712 | $0 | 0 | +12,712 | New Buy |
| FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #11 | $52,460 | 10,750 | $84,388 | 10,750 | 00.00% | Unchanged |
| GTS SECURITIES LLC |
| <0.01% | — | #9 | $48,800 | 10,000 | $0 | 0 | +10,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #23 | $11,658 | 2,389 | $2,714 | 338 | +2,051+606.80% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #22 | $3,113 | 638 | $5,008 | 638 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #25 | $1,035 | 212 | $1,664 | 212 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #15 | $825 | 169 | $973 | 124 | +45+36.29% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #26 | $561 | 115 | $903 | 115 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #29 | $73 | 15 | $93 | 15 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #27 | $73 | 15 | $117 | 15 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #28 | $59 | 12 | $94 | 12 | 00.00% | Unchanged |
| LRI Investments, LLC |
| <0.01% | <0.01% | #20 | $59 | 12 | $94 | 12 | 00.00% | Unchanged |
| HARBOUR INVESTMENTS, INC. |
| <0.01% | <0.01% | #24 | $15 | 3 | $24 | 3 | 00.00% | Unchanged |
