| Velan Capital Investment Management LP |
| 4.1% | 2.71% | #1 | $6.7M | 827,500 | $4.3M | 827,500 | 00.00% | Unchanged |
| Rubric Capital Management LP |
| 0.05% | 0.04% | #5 | $5.4M | 669,500 | $3.6M | 687,500 | -18,000-2.62% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.07% | 0.06% | #4 | $4.6M | 563,239 | $2.9M | 563,239 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #8 | $4.6M | 561,751 | $0 | 0 | +561,751 | New Buy |
| Stonepine Capital Management, LLC |
| 0.49% | 0.06% | #2 | $3.2M | 456,439 | $156,900 | 30,000 | +426,439+1,421.46% | Add |
| Boxer Capital Management, LLC |
| 0.13% | — | #3 | $1.7M | 205,000 | $0 | 0 | +205,000 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $665,351 | 81,839 | $449,602 | 85,966 | -4,127-4.80% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $657,586 | 80,879 | $403,016 | 77,054 | +3,825+4.96% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #16 | $589,141 | 72,465 | $605,221 | 115,721 | -43,256-37.38% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #14 | $314,777 | 38,718 | $201,073 | 38,446 | +272+0.71% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #20 | $308,769 | 37,979 | $198,630 | 37,979 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #7 | $287,412 | 35,352 | $0 | 0 | +35,352 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #10 | $256,347 | 31,531 | $0 | 0 | +31,531 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #23 | $223,534 | 27,495 | $144,918 | 27,709 | -214-0.77% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #19 | $121,901 | 14,994 | $78,419 | 14,994 | 00.00% | Unchanged |
| SCOTIA CAPITAL INC. |
| <0.01% | <0.01% | #11 | $117,015 | 14,393 | $82,859 | 15,843 | -1,450-9.15% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #13 | $114,080 | 14,032 | $0 | 0 | +14,032 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #21 | $54,984 | 6,763 | $12,254 | 2,343 | +4,420+188.65% | Add |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #9 | $28,496 | 3,505 | $18,315 | 3,502 | +3+0.09% | Add |
| Federation des caisses Desjardins du Quebec |
| <0.01% | — | #15 | $21,097 | 2,595 | $0 | 0 | +2,595 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #25 | $15,000 | 1,851 | $9,000 | 1,659 | +192+11.57% | Add |
| MCGUIRE CAPITAL ADVISORS INC |
| 0.01% | 0.01% | #6 | $12,195 | 1,500 | $7,845 | 1,500 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | — | #28 | $11,382 | 1,400 | $0 | 0 | +1,400 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #12 | $10,000 | 1,230 | $2,652 | 507 | +723+142.60% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #22 | $9,122 | 1,122 | $0 | 0 | +1,122 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #30 | $8,667 | 1,130 | $0 | 0 | +1,130 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #27 | $1,317 | 162 | $847 | 162 | 00.00% | Unchanged |
| TD Waterhouse Canada Inc. |
| <0.01% | <0.01% | #24 | $1,098 | 142 | $792 | 142 | 00.00% | Unchanged |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #31 | $301 | 37 | $0 | 0 | +37 | New Buy |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | — | #32 | $66 | 8 | $0 | 0 | +8 | New Buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | — | #33 | $33 | 4 | $0 | 0 | +4 | New Buy |
| Banque Cantonale Vaudoise |
| <0.01% | — | #26 | $24 | 3 | $0 | 0 | +3 | New Buy |
| DANSKE BANK A/S |
| <0.01% | <0.01% | #34 | $8 | 1 | $5 | 1 | 00.00% | Unchanged |
| LRI Investments, LLC |
| <0.01% | <0.01% | #29 | $8 | 1 | $5 | 1 | 00.00% | Unchanged |
