| Yu Fan |
| 20.63% | 7.36% | #1 | $22.3M | 4.9M | $7.1M | 2.1M | +2.8M+134.85% | Add |
| ACUTA CAPITAL PARTNERS, LLC |
| 14.96% | 8.3% | #2 | $21.5M | 4.7M | $11.8M | 3.4M | +1.3M+37.40% | Add |
| QVT Financial LP |
| 1.24% | 1.17% | #7 | $21.1M | 4.6M | $15.9M | 4.6M | 00.00% | Unchanged |
| MONTANOVA CAPITAL, LLC |
| 0.36% | 0.33% | #9 | $19.7M | 4.3M | $12.8M | 3.7M | +600,000+16.22% | Add |
| ORBIMED ADVISORS LLC |
| 0.34% | 0.28% | #10 | $18.0M | 3.9M | $14.4M | 4.2M | -231,704-5.56% | Reduce |
| Avoro Capital Advisors LLC |
| 0.12% | 0.1% | #13 | $13.1M | 2.8M | $9.8M | 2.8M | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.22% | 0.2% | #12 | $10.7M | 2.3M | $7.2M | 2.1M | +255,102+12.25% | Add |
| KVP Capital Advisors, LP |
| 7.28% | 5.58% | #3 | $9.9M | 2.2M | $7.5M | 2.2M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $8.8M | 1.9M | $1.2M | 351,385 | +1.6M+447.21% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $6.4M | 1.4M | $4.5M | 1.3M | +72,791+5.53% | Add |
| ADAR1 Capital Management, LLC |
| 0.28% | 0.03% | #11 | $6.1M | 1.3M | $443,335 | 128,503 | +1.2M+943.86% | Add |
| ACORN CAPITAL ADVISORS, LLC |
| 1.42% | 1.12% | #5 | $5.2M | 1.1M | $3.9M | 1.1M | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 0.67% | 0.6% | #8 | $4.7M | 1.0M | $3.2M | 939,369 | +81,668+8.69% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #35 | $4.1M | 899,780 | $1.6M | 457,540 | +442,240+96.66% | Add |
| Ally Bridge Group (NY) LLC |
| 3.31% | 2.28% | #4 | $3.7M | 817,939 | $2.8M | 817,939 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.01% | <0.01% | #17 | $2.0M | 436,614 | $971,165 | 281,497 | +155,117+55.10% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $1.9M | 413,822 | $1.5M | 428,622 | -14,800-3.45% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #48 | $1.8M | 386,982 | $553,318 | 160,382 | +226,600+141.29% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #28 | $1.7M | 380,406 | $1.1M | 309,674 | +70,732+22.84% | Add |
| Eversept Partners, LP |
| 0.07% | 0.06% | #14 | $1.4M | 303,306 | $1.1M | 306,800 | -3,494-1.14% | Reduce |
| Verdad Advisers, LP |
| 1.32% | 0.45% | #6 | $1.4M | 301,483 | $398,420 | 115,484 | +185,999+161.06% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #25 | $1.4M | 296,612 | $943,513 | 273,482 | +23,130+8.46% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #22 | $1.3M | 288,117 | $1.9M | 550,441 | -262,324-47.66% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #37 | $1.2M | 264,689 | $370,067 | 107,266 | +157,423+146.76% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #34 | $1.1M | 246,907 | $741,153 | 214,827 | +32,080+14.93% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #53 | $1.0M | 219,217 | $0 | 0 | +219,217 | New Buy |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $782,644 | 170,883 | $239,000 | 70,101 | +100,782+143.77% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #16 | $757,001 | 165,284 | $742,730 | 215,284 | -50,000-23.23% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #50 | $580,552 | 126,758 | $196,346 | 56,912 | +69,846+122.73% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #47 | $378,455 | 82,632 | $0 | 0 | +82,632 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #51 | $361,051 | 78,832 | $0 | 0 | +78,832 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #32 | $261,651 | 57,129 | $96,690 | 28,026 | +29,103+103.84% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #41 | $237,427 | 51,840 | $0 | 0 | +51,840 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #57 | $232,851 | 50,841 | $39,461 | 11,438 | +39,403+344.49% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #36 | $224,388 | 48,993 | $166,659 | 48,307 | +686+1.42% | Add |
| Nuveen, LLC |
| <0.01% | — | #52 | $200,599 | 43,799 | $0 | 0 | +43,799 | New Buy |
| Jump Financial, LLC |
| <0.01% | — | #23 | $186,864 | 40,800 | $0 | 0 | +40,800 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #64 | $179,440 | 39,179 | $0 | 0 | +39,179 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #67 | $158,587 | 34,626 | $182,370 | 52,861 | -18,235-34.50% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $153,064 | 33,420 | $103,810 | 30,090 | +3,330+11.07% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #54 | $145,039 | 31,668 | $0 | 0 | +31,668 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #62 | $137,794 | 30,086 | $316,889 | 91,852 | -61,766-67.25% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $137,309 | 29,980 | $3,513 | 1,849 | +28,131+1,521.42% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #60 | $124,457 | 27,174 | $0 | 0 | +27,174 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #65 | $121,869 | 26,609 | $0 | 0 | +26,609 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #43 | $112,338 | 24,529 | $0 | 0 | +24,529 | New Buy |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #20 | $111,583 | 24,363 | $0 | 0 | +24,363 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #55 | $89,205 | 19,477 | $69,611 | 20,177 | -700-3.47% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #40 | $85,646 | 18,700 | $0 | 0 | +18,700 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #24 | $84,831 | 18,522 | $79,291 | 22,983 | -4,461-19.41% | Reduce |
