| MONTANOVA CAPITAL, LLC |
| 0.94% | 0.18% | #7 | $51.4M | 22.9M | $7.1M | 7.9M | +15.0M+189.06% | Add |
| TCG Crossover Management, LLC |
| 0.78% | — | #9 | $32.5M | 14.5M | $0 | 0 | +14.5M | New Buy |
| FMR LLC |
| <0.01% | — | #29 | $18.3M | 8.2M | $0 | 0 | +8.2M | New Buy |
| Commodore Capital LP |
| 0.97% | — | #6 | $16.4M | 7.3M | $0 | 0 | +7.3M | New Buy |
| Spruce Street Capital LP |
| 2.35% | — | #2 | $12.0M | 5.4M | $0 | 0 | +5.4M | New Buy |
| 683 Capital Management, LLC |
| 0.56% | 0.15% | #10 | $11.3M | 5.1M | $3.0M | 3.3M | +1.8M+52.79% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.03% | — | #16 | $7.4M | 3.3M | $0 | 0 | +3.3M | New Buy |
| STEMPOINT CAPITAL LP |
| 1.03% | — | #5 | $7.2M | 3.2M | $0 | 0 | +3.2M | New Buy |
| GREAT POINT PARTNERS LLC |
| 1.29% | — | #4 | $6.8M | 3.0M | $0 | 0 | +3.0M | New Buy |
| ADAR1 Capital Management, LLC |
| 0.31% | 0.01% | #11 | $6.7M | 3.0M | $141,558 | 158,271 | +2.8M+1,795.48% | Add |
| Kalehua Capital Management LLC |
| 4.65% | — | #1 | $6.5M | 2.9M | $0 | 0 | +2.9M | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #28 | $5.8M | 2.6M | $0 | 0 | +2.6M | New Buy |
| Woodline Partners LP |
| 0.01% | — | #18 | $4.7M | 2.1M | $0 | 0 | +2.1M | New Buy |
| Squadron Capital Management LLC |
| 1.39% | — | #3 | $4.5M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Eversept Partners, LP |
| 0.15% | 0.08% | #13 | $2.9M | 1.3M | $1.6M | 1.8M | -454,504-25.85% | Reduce |
| FRANKLIN RESOURCES INC |
| <0.01% | — | #34 | $2.3M | 1.0M | $0 | 0 | +1.0M | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #48 | $2.1M | 915,614 | $839,643 | 626,599 | +289,015+46.12% | Add |
| Jefferies Financial Group Inc. |
| 0.01% | — | #19 | $1.7M | 775,349 | $0 | 0 | +775,349 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #27 | $1.6M | 711,296 | $493,385 | 554,364 | +156,932+28.31% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #37 | $1.3M | 567,049 | $0 | 0 | +567,049 | New Buy |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #42 | $844,845 | 377,163 | $354,007 | 395,803 | -18,640-4.71% | Reduce |
| XTX Topco Ltd |
| 0.01% | <0.01% | #20 | $751,099 | 335,312 | $79,519 | 88,908 | +246,404+277.14% | Add |
| T3 Companies, LLC |
| 0.79% | 0.29% | #8 | $741,471 | 331,014 | $260,283 | 291,014 | +40,000+13.75% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | — | #32 | $601,030 | 268,317 | $0 | 0 | +268,317 | New Buy |
| Verde Servicos Internacionais S.A. |
| 0.2% | — | #12 | $562,240 | 251,000 | $0 | 0 | +251,000 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #51 | $559,610 | 249,826 | $30,946 | 34,600 | +215,226+622.04% | Add |
| DCF Advisers, LLC |
| 0.09% | 0.04% | #14 | $511,840 | 228,500 | $141,762 | 158,500 | +70,000+44.16% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #50 | $454,697 | 202,990 | $73,731 | 82,437 | +120,553+146.24% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #39 | $405,704 | 181,118 | $169,109 | 189,075 | -7,957-4.21% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #36 | $402,333 | 179,613 | $270,097 | 301,987 | -122,374-40.52% | Reduce |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #33 | $353,248 | 157,700 | $10,643 | 11,900 | +145,800+1,225.21% | Add |
| Quadrature Capital Ltd |
| <0.01% | — | #24 | $348,132 | 155,416 | $0 | 0 | +155,416 | New Buy |
| MYDA Advisors LLC |
| 0.05% | — | #15 | $336,000 | 150,000 | $0 | 0 | +150,000 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #31 | $320,790 | 143,210 | $14,000 | 15,997 | +127,213+795.23% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #45 | $295,317 | 131,838 | $9,481 | 10,600 | +121,238+1,143.75% | Add |
| Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #30 | $212,800 | 95,000 | $84,968 | 95,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #54 | $177,258 | 79,133 | $26,641 | 29,800 | +49,333+165.55% | Add |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #49 | $142,027 | 63,405 | $44,362 | 49,600 | +13,805+27.83% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #57 | $141,084 | 62,984 | $68,971 | 77,114 | -14,130-18.32% | Reduce |
| INSIGNEO ADVISORY SERVICES, LLC |
| 0.01% | <0.01% | #22 | $134,960 | 60,250 | $53,888 | 60,250 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | — | #58 | $98,226 | 43,851 | $0 | 0 | +43,851 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #59 | $97,825 | 43,672 | $39,060 | 43,672 | 00.00% | Unchanged |
| FRED ALGER MANAGEMENT, LLC |
| <0.01% | — | #38 | $95,128 | 42,468 | $0 | 0 | +42,468 | New Buy |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #40 | $56,840 | 25,375 | $335 | 375 | +25,000+6,666.67% | Add |
| AXQ CAPITAL, LP |
| <0.01% | — | #23 | $40,665 | 18,154 | $0 | 0 | +18,154 | New Buy |
| China Universal Asset Management Co., Ltd. |
| <0.01% | — | #26 | $35,840 | 16,000 | $0 | 0 | +16,000 | New Buy |
| Engineers Gate Manager LP |
| <0.01% | <0.01% | #35 | $34,489 | 15,397 | $13,771 | 15,397 | 00.00% | Unchanged |
| Pacifica Partners Inc. |
| 0.01% | <0.01% | #21 | $31,688 | 14,210 | $12,704 | 14,210 | 00.00% | Unchanged |
| Concurrent Investment Advisors, LLC |
| <0.01% | <0.01% | #41 | $28,337 | 12,651 | $12,925 | 14,451 | -1,800-12.46% | Reduce |
| Sanctuary Advisors, LLC |
| <0.01% | <0.01% | #47 | $24,640 | 11,000 | $9,838 | 11,000 | 00.00% | Unchanged |
