| Nantahala Capital Management, LLC |
| 0.44% | 0.77% | #3 | $13.2M | 12.3M | $21.0M | 5.6M | +6.7M+120.21% | Add |
| Redmile Group, LLC |
| 0.83% | 3.84% | #2 | $12.3M | 11.5M | $58.0M | 15.5M | -3.9M-25.49% | Reduce |
| TCG Crossover Management, LLC |
| 0.29% | 1.22% | #4 | $12.2M | 11.4M | $42.7M | 11.4M | 00.00% | Unchanged |
| Prosight Management, LP |
| 1.44% | 5.1% | #1 | $8.4M | 7.8M | $31.1M | 8.3M | -475,251-5.73% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $7.5M | 7.0M | $23.4M | 6.3M | +769,346+12.31% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #15 | $3.9M | 3.7M | $12.8M | 3.4M | +267,015+7.83% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #50 | $3.3M | 3.1M | $14.7M | 3.7M | -617,894-16.84% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #22 | $3.3M | 3.0M | $12.2M | 3.3M | -204,619-6.29% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $2.2M | 2.1M | $1.5M | 399,721 | +1.7M+413.69% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #49 | $2.0M | 1.9M | $6.2M | 1.7M | +261,398+15.81% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $1.8M | 1.7M | $5.9M | 1.6M | +119,174+7.61% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $1.5M | 1.4M | $4.5M | 1.2M | +241,790+20.09% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #57 | $1.4M | 1.3M | $5.0M | 1.3M | -36,811-2.78% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $959,888 | 897,092 | $3.9M | 1.0M | -136,185-13.18% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $827,553 | 773,414 | $2.5M | 668,022 | +105,392+15.78% | Add |
| Blue Owl Capital Holdings LP |
| 0.11% | 0.7% | #6 | $784,918 | 733,568 | $2.6M | 733,568 | 00.00% | Unchanged |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #35 | $769,672 | 719,320 | $911,910 | 243,176 | +476,144+195.80% | Add |
| Opaleye Management Inc. |
| 0.07% | — | #7 | $749,000 | 700,000 | $0 | 0 | +700,000 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $704,193 | 658,125 | $891,141 | 237,637 | +420,488+176.95% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #37 | $698,548 | 652,849 | $3.2M | 860,491 | -207,642-24.13% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $635,607 | 594,025 | $2.1M | 552,201 | +41,824+7.57% | Add |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.15% | 0.94% | #5 | $622,322 | 581,609 | $3.7M | 990,778 | -409,169-41.30% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | 0.01% | #21 | $612,913 | 572,816 | $2.6M | 691,275 | -118,459-17.14% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #60 | $556,714 | 520,293 | $1.7M | 458,902 | +61,391+13.38% | Add |
| SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #38 | $431,345 | 418,782 | $1.5M | 418,782 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $385,468 | 360,251 | $1.7M | 449,122 | -88,871-19.79% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #64 | $328,644 | 307,144 | $985,436 | 262,783 | +44,361+16.88% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #44 | $306,664 | 286,604 | $955,910 | 254,909 | +31,695+12.43% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #66 | $269,260 | 251,645 | $758,455 | 202,254 | +49,391+24.42% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #68 | $250,760 | 234,355 | $866,491 | 231,064 | +3,291+1.42% | Add |
| Florida Trust Wealth Management Co |
| 0.01% | 0.02% | #14 | $246,565 | 230,435 | $564,131 | 150,435 | +80,000+53.18% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $239,742 | 224,058 | $841,354 | 224,361 | -303-0.14% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #65 | $189,061 | 176,693 | $548,468 | 146,258 | +30,435+20.81% | Add |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #36 | $171,414 | 160,200 | $475,586 | 126,823 | +33,377+26.32% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #86 | $157,116 | 152,540 | $1.8M | 489,079 | -336,539-68.81% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | — | #28 | $151,238 | 141,344 | $0 | 0 | +141,344 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #20 | $150,165 | 140,341 | $65,333 | 17,422 | +122,919+705.54% | Add |
| FMR LLC |
| <0.01% | <0.01% | #89 | $142,069 | 132,775 | $647,543 | 172,678 | -39,903-23.11% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #56 | $125,571 | 117,364 | $390,185 | 104,051 | +13,313+12.79% | Add |
| Focus Partners Wealth |
| <0.01% | — | #54 | $119,627 | 111,801 | $0 | 0 | +111,801 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #24 | $113,088 | 105,690 | $0 | 0 | +105,690 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #70 | $108,470 | 108,470 | $147,731 | 41,850 | +66,620+159.19% | Add |
| Wilmington Savings Fund Society, FSB |
| <0.01% | 0.01% | #19 | $107,000 | 100,000 | $375,000 | 100,000 | 00.00% | Unchanged |
| Revolve Wealth Partners, LLC |
| 0.01% | — | #12 | $107,000 | 100,000 | $0 | 0 | +100,000 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #79 | $100,864 | 94,264 | $173,758 | 46,335 | +47,929+103.44% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #75 | $89,285 | 83,444 | $300,769 | 80,205 | +3,239+4.04% | Add |
| DAFNA Capital Management LLC |
| 0.02% | 0.06% | #9 | $82,477 | 77,081 | $270,304 | 72,081 | +5,000+6.94% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #87 | $80,100 | 74,860 | $263,000 | 70,047 | +4,813+6.87% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #90 | $65,556 | 61,267 | $580,361 | 154,763 | -93,496-60.41% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $60,458 | 56,503 | $333,401 | 88,907 | -32,404-36.45% | Reduce |
