| Bain Capital Life Sciences Investors, LLC |
| 0.87% | 1.73% | #2 | $14.6M | 8.4M | $19.1M | 8.4M | 00.00% | Unchanged |
| ARMISTICE CAPITAL, LLC |
| 0.07% | — | #6 | $5.8M | 3.3M | $0 | 0 | +3.3M | New Buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd |
| 37.39% | 34.13% | #1 | $3.2M | 1.8M | $4.2M | 1.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $1.7M | 982,034 | $2.2M | 982,494 | -460-0.05% | Reduce |
| Evernest Financial Advisors, LLC |
| 0.18% | 0.21% | #4 | $875,380 | 506,000 | $1.0M | 432,510 | +73,490+16.99% | Add |
| ADVENT INTERNATIONAL, L.P. |
| <0.01% | 0.03% | #9 | $657,044 | 379,794 | $1.3M | 552,377 | -172,583-31.24% | Reduce |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.08% | 0.32% | #5 | $627,464 | 362,696 | $2.0M | 883,931 | -521,235-58.97% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #14 | $409,316 | 236,599 | $643,046 | 283,280 | -46,681-16.48% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $394,706 | 228,041 | $561,331 | 247,177 | -19,136-7.74% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $366,935 | 212,101 | $287,421 | 126,617 | +85,484+67.51% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #27 | $328,410 | 189,832 | $356,916 | 157,232 | +32,600+20.73% | Add |
| Legato Capital Management LLC |
| 0.02% | — | #7 | $206,794 | 119,534 | $0 | 0 | +119,534 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #18 | $191,137 | 110,484 | $249,046 | 109,712 | +772+0.70% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #20 | $180,253 | 104,192 | $198,679 | 87,589 | +16,603+18.96% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #28 | $162,402 | 93,874 | $213,094 | 93,874 | 00.00% | Unchanged |
| FIFTH LANE CAPITAL, LP |
| 0.19% | 0.2% | #3 | $161,170 | 71,000 | $161,170 | 71,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | <0.01% | #10 | $137,928 | 79,727 | $138,629 | 61,070 | +18,657+30.55% | Add |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #15 | $115,683 | 66,869 | $646,532 | 284,816 | -217,947-76.52% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #25 | $72,843 | 42,106 | $109,593 | 48,279 | -6,173-12.79% | Reduce |
| ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #11 | $66,271 | 38,307 | $53,000 | 23,181 | +15,126+65.25% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #31 | $47,726 | 27,587 | $68,637 | 20,550 | +7,037+34.24% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #29 | $44,861 | 25,931 | $301,739 | 132,925 | -106,994-80.49% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #17 | $39,951 | 23,093 | $0 | 0 | +23,093 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #30 | $27,926 | 16,142 | $0 | 0 | +16,142 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #21 | $24,739 | 14,300 | $31,780 | 14,000 | +300+2.14% | Add |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.02% | 0.03% | #8 | $21,625 | 12,500 | $28,375 | 12,500 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #24 | $20,134 | 11,638 | $38,413 | 16,922 | -5,284-31.23% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #23 | $20,120 | 11,630 | $26,400 | 11,630 | 00.00% | Unchanged |
| Larson Financial Group LLC |
| <0.01% | <0.01% | #13 | $14,523 | 8,395 | $12,465 | 5,491 | +2,904+52.89% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $11,430 | 6,607 | $25,542 | 11,252 | -4,645-41.28% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #16 | $3,287 | 1,900 | $0 | 0 | +1,900 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #34 | $583 | 337 | $49,020 | 21,595 | -21,258-98.44% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #35 | $189 | 109 | $242 | 109 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #26 | $61 | 35 | $0 | 0 | +35 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #33 | $26 | 15 | $34 | 15 | 00.00% | Unchanged |
