| Nextech Invest Ltd. |
| 0.2% | 1.37% | #3 | $4.1M | 7.4M | $19.4M | 7.4M | 00.00% | Unchanged |
| Deep Track Capital, LP |
| 0.06% | 0.32% | #6 | $4.1M | 7.4M | $19.4M | 7.4M | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.13% | 0.74% | #5 | $3.9M | 7.1M | $18.2M | 7.0M | +100,000+1.44% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #37 | $3.4M | 6.2M | $2.2M | 846,696 | +5.3M+628.63% | Add |
| Avidity Partners Management LP |
| 0.44% | 2.65% | #1 | $2.8M | 5.0M | $13.1M | 5.0M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #22 | $2.1M | 3.8M | $10.0M | 3.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $1.9M | 3.4M | $9.0M | 3.4M | +99+0.00% | Add |
| Octagon Capital Advisors LP |
| 0.15% | 1.52% | #4 | $1.7M | 3.1M | $13.8M | 5.3M | -2.2M-41.90% | Reduce |
| Blue Owl Capital Holdings LP |
| 0.24% | 3.58% | #2 | $1.6M | 2.9M | $13.3M | 5.1M | -2.2M-42.35% | Reduce |
| TCG Crossover Management, LLC |
| 0.04% | 0.2% | #8 | $1.5M | 2.7M | $7.0M | 2.7M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #35 | $1.0M | 1.8M | $1.6M | 603,767 | +1.2M+203.15% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #46 | $782,898 | 1.4M | $611,788 | 233,507 | +1.2M+505.30% | Add |
| MPM BioImpact LLC |
| 0.04% | 2.16% | #7 | $719,542 | 1.3M | $28.0M | 10.7M | -9.4M-87.84% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $576,831 | 1.0M | $479,457 | 182,999 | +858,400+469.07% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #20 | $559,940 | 1.0M | $0 | 0 | +1.0M | New Buy |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.05% | #10 | $415,962 | 750,969 | $919,866 | 351,094 | +399,875+113.89% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #41 | $357,382 | 645,209 | $1.1M | 436,931 | +208,278+47.67% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #49 | $353,938 | 638,878 | $0 | 0 | +638,878 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #39 | $340,967 | 615,576 | $270,531 | 103,256 | +512,320+496.16% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $240,374 | 433,888 | $894,321 | 341,344 | +92,544+27.11% | Add |
| MARSHALL WACE, LLP |
| <0.01% | 0.01% | #28 | $211,490 | 384,528 | $7.7M | 2.9M | -2.6M-86.96% | Reduce |
| XTX Topco Ltd |
| <0.01% | — | #16 | $163,013 | 294,301 | $0 | 0 | +294,301 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #30 | $142,390 | 257,068 | $29,863 | 11,398 | +245,670+2,155.38% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #47 | $126,206 | 227,850 | $0 | 0 | +227,850 | New Buy |
| Pathstone Holdings, LLC |
| <0.01% | <0.01% | #25 | $119,019 | 214,875 | $288,839 | 110,244 | +104,631+94.91% | Add |
| Timothy G. Youngquist 2020 Irrevocable Trust |
| <0.01% | — | #13 | $109,885 | 198,384 | $0 | 0 | +198,384 | New Buy |
| Graham Capital Management, L.P. |
| <0.01% | — | #17 | $90,578 | 163,527 | $0 | 0 | +163,527 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | — | #12 | $88,515 | 159,804 | $0 | 0 | +159,804 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $81,582 | 147,287 | $3.7M | 1.4M | -1.3M-89.66% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #33 | $74,943 | 135,300 | $0 | 0 | +135,300 | New Buy |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #34 | $69,709 | 125,852 | $330,518 | 126,152 | -300-0.24% | Reduce |
| Private Advisor Group, LLC |
| <0.01% | — | #26 | $69,709 | 125,852 | $0 | 0 | +125,852 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #48 | $69,524 | 125,518 | $0 | 0 | +125,518 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #55 | $60,576 | 109,362 | $0 | 0 | +109,362 | New Buy |
| NATIXIS |
| <0.01% | — | #27 | $54,634 | 97,109 | $0 | 0 | +97,109 | New Buy |
| Clear Harbor Asset Management, LLC |
| <0.01% | 0.02% | #14 | $51,404 | 92,804 | $243,146 | 92,804 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #50 | $49,985 | 90,882 | $0 | 0 | +90,882 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #58 | $47,071 | 84,981 | $0 | 0 | +84,981 | New Buy |
| Woodline Partners LP |
| <0.01% | <0.01% | #29 | $43,167 | 77,933 | $655,231 | 250,088 | -172,155-68.84% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #62 | $42,948 | 77,538 | $0 | 0 | +77,538 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #52 | $38,952 | 70,323 | $31,917 | 12,182 | +58,141+477.27% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $38,688 | 69,844 | $0 | 0 | +69,844 | New Buy |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | <0.01% | #15 | $34,034 | 61,444 | $32,941 | 12,573 | +48,871+388.70% | Add |
| Velan Capital Investment Management LP |
| 0.02% | 0.16% | #9 | $33,068 | 59,700 | $262,000 | 100,000 | -40,300-40.30% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #53 | $32,686 | 59,000 | $0 | 0 | +59,000 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $29,531 | 53,402 | $301,007 | 114,888 | -61,486-53.52% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #40 | $29,196 | 52,709 | $0 | 0 | +52,709 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #68 | $28,036 | 50,617 | $0 | 0 | +50,617 | New Buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #43 | $23,761 | 42,898 | $0 | 0 | +42,898 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $22,288 | 38,621 | $25,534 | 10,422 | +28,199+270.57% | Add |
