| RTW INVESTMENTS, LP |
| 0.35% | 0.35% | #3 | $41.2M | 9.6M | $35.3M | 8.3M | +1.3M+15.05% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.33% | 0.42% | #4 | $21.7M | 5.0M | $21.4M | 5.0M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $10.8M | 2.5M | $2.7M | 635,714 | +1.9M+294.89% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $8.7M | 2.0M | $9.4M | 2.2M | -181,403-8.23% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $4.4M | 1.0M | $2.1M | 485,492 | +522,416+107.61% | Add |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #13 | $4.3M | 1.0M | $4.3M | 1.0M | 00.00% | Unchanged |
| Propel Bio Management, LLC |
| 2.02% | 2.41% | #1 | $3.9M | 896,701 | $3.8M | 896,701 | 00.00% | Unchanged |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | — | #27 | $2.8M | 642,154 | $0 | 0 | +642,154 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #46 | $2.2M | 516,050 | $719,993 | 169,410 | +346,640+204.62% | Add |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.09% | <0.01% | #8 | $1.8M | 424,000 | $80,754 | 19,001 | +404,999+2,131.46% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #35 | $1.5M | 349,544 | $1.1M | 265,499 | +84,045+31.66% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #38 | $1.5M | 343,640 | $502,665 | 118,274 | +225,366+190.55% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #37 | $1.4M | 325,773 | $213,818 | 50,310 | +275,463+547.53% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #33 | $1.3M | 292,253 | $999,660 | 235,214 | +57,039+24.25% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $1.2M | 274,973 | $0 | 0 | +274,973 | New Buy |
| Knott David M Jr |
| 0.58% | 0.65% | #2 | $1.1M | 253,651 | $1.1M | 253,651 | 00.00% | Unchanged |
| Flat Footed LLC |
| 0.08% | — | #9 | $1.1M | 251,372 | $0 | 0 | +251,372 | New Buy |
| Simplify Asset Management Inc. |
| 0.01% | 0.01% | #11 | $946,655 | 219,387 | $932,395 | 219,387 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #45 | $775,000 | 179,606 | $659,779 | 155,242 | +24,364+15.69% | Add |
| DAFNA Capital Management LLC |
| 0.1% | 0.12% | #6 | $547,319 | 126,841 | $539,074 | 126,841 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #26 | $388,350 | 90,000 | $301,325 | 70,900 | +19,100+26.94% | Add |
| IFP Advisors, Inc |
| 0.01% | 0.01% | #16 | $386,659 | 89,608 | $420,270 | 98,887 | -9,279-9.38% | Reduce |
| Daytona Street Capital LLC |
| 0.28% | 0.18% | #5 | $379,336 | 96,398 | $235,443 | 52,600 | +43,798+83.27% | Add |
| Bank of New York Mellon Corp |
| <0.01% | — | #47 | $371,534 | 86,103 | $0 | 0 | +86,103 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $370,620 | 85,891 | $336,536 | 79,185 | +6,706+8.47% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #19 | $347,789 | 80,600 | $300,050 | 70,600 | +10,000+14.16% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #57 | $283,944 | 65,804 | $414,464 | 97,521 | -31,717-32.52% | Reduce |
| Nuveen, LLC |
| <0.01% | — | #49 | $224,889 | 52,118 | $0 | 0 | +52,118 | New Buy |
| Holos Integrated Wealth LLC |
| 0.1% | 0.11% | #7 | $204,316 | 51,595 | $219,795 | 51,595 | 00.00% | Unchanged |
| NewEdge Advisors, LLC |
| <0.01% | <0.01% | #25 | $190,218 | 44,083 | $187,353 | 44,083 | 00.00% | Unchanged |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #21 | $187,642 | 43,486 | $0 | 0 | +43,486 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #52 | $171,383 | 39,672 | $0 | 0 | +39,672 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #23 | $167,482 | 38,814 | $0 | 0 | +38,814 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #56 | $156,876 | 36,356 | $0 | 0 | +36,356 | New Buy |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #40 | $152,643 | 35,375 | $77,669 | 18,275 | +17,100+93.57% | Add |
| Affinity Asset Advisors, LLC |
| 0.01% | 0.09% | #18 | $144,121 | 33,400 | $1.7M | 402,550 | -369,150-91.70% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #60 | $141,053 | 32,689 | $0 | 0 | +32,689 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $137,813 | 31,940 | $0 | 0 | +31,940 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $125,826 | 29,160 | $25,601 | 10,323 | +18,837+182.48% | Add |
| ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #24 | $122,917 | 28,486 | $62,000 | 14,656 | +13,830+94.36% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #64 | $115,469 | 26,760 | $301,665 | 70,980 | -44,220-62.30% | Reduce |
| Meramec Financial Planners, LLC |
| 0.04% | 0.05% | #10 | $114,600 | 30,000 | $130,500 | 30,000 | 00.00% | Unchanged |
| AXQ CAPITAL, LP |
| 0.01% | — | #12 | $109,808 | 25,448 | $0 | 0 | +25,448 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #66 | $106,533 | 24,689 | $0 | 0 | +24,689 | New Buy |
| MetLife Investment Management, LLC |
| <0.01% | — | #28 | $103,534 | 23,994 | $0 | 0 | +23,994 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #69 | $102,792 | 23,822 | $224,234 | 52,761 | -28,939-54.85% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #70 | $99,181 | 20,880 | $17,330 | 4,258 | +16,622+390.37% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #44 | $97,359 | 22,563 | $255,455 | 60,107 | -37,544-62.46% | Reduce |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #51 | $91,047 | 21,100 | $48,025 | 11,300 | +9,800+86.73% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #41 | $88,026 | 20,400 | $0 | 0 | +20,400 | New Buy |
