| AIGH Capital Management LLC |
| 0.85% | — | #1 | $13.5M | 250,000 | $0 | 0 | +250,000 | New Buy |
| ORBIMED ADVISORS LLC |
| 0.2% | — | #9 | $10.8M | 200,000 | $0 | 0 | +200,000 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #38 | $10.1M | 187,836 | $1.1M | 16,938 | +170,898+1,008.96% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $8.7M | 160,981 | $7.3M | 111,888 | +49,093+43.88% | Add |
| AWM Investment Company, Inc. |
| 0.69% | — | #3 | $7.9M | 146,988 | $0 | 0 | +146,988 | New Buy |
| Ikarian Capital, LLC |
| 0.7% | 0.64% | #2 | $6.6M | 121,356 | $7.9M | 121,356 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #40 | $6.4M | 119,331 | $0 | 0 | +119,331 | New Buy |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #19 | $4.4M | 81,671 | $3.4M | 51,671 | +30,000+58.06% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $3.8M | 70,548 | $842,729 | 12,889 | +57,659+447.35% | Add |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.23% | #11 | $3.7M | 67,717 | $3.8M | 58,600 | +9,117+15.56% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $2.8M | 51,905 | $4.6M | 69,999 | -18,094-25.85% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #44 | $2.7M | 50,450 | $352,890 | 5,400 | +45,050+834.26% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.04% | #16 | $2.3M | 42,080 | $2.7M | 42,080 | 00.00% | Unchanged |
| STEMPOINT CAPITAL LP |
| 0.32% | 0.08% | #5 | $2.2M | 41,388 | $415,626 | 6,360 | +35,028+550.75% | Add |
| Eversept Partners, LP |
| 0.11% | — | #13 | $2.2M | 40,000 | $0 | 0 | +40,000 | New Buy |
| Carlyle Group Inc. |
| 0.02% | 0.02% | #17 | $2.1M | 38,620 | $2.5M | 38,620 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #37 | $1.7M | 32,348 | $359,817 | 5,506 | +26,842+487.50% | Add |
| Affinity Asset Advisors, LLC |
| 0.07% | — | #14 | $1.6M | 30,000 | $0 | 0 | +30,000 | New Buy |
| DIADEMA PARTNERS LP |
| 0.2% | 0.11% | #10 | $1.6M | 30,000 | $653,500 | 10,000 | +20,000+200.00% | Add |
| Stonepine Capital Management, LLC |
| 0.24% | — | #8 | $1.6M | 28,795 | $0 | 0 | +28,795 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | — | #22 | $1.5M | 28,278 | $0 | 0 | +28,278 | New Buy |
| Quinn Opportunity Partners LLC |
| 0.07% | 0.09% | #15 | $1.4M | 26,810 | $1.8M | 26,810 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #36 | $1.3M | 23,381 | $256,107 | 3,919 | +19,462+496.61% | Add |
| ExodusPoint Capital Management, LP |
| 0.01% | — | #20 | $1.2M | 22,000 | $0 | 0 | +22,000 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #41 | $1.1M | 21,083 | $0 | 0 | +21,083 | New Buy |
| Rosalind Advisors, Inc. |
| 0.26% | — | #7 | $1.1M | 20,000 | $0 | 0 | +20,000 | New Buy |
| Knott David M Jr |
| 0.58% | — | #4 | $1.1M | 20,000 | $0 | 0 | +20,000 | New Buy |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #33 | $1.0M | 18,834 | $0 | 0 | +18,834 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #47 | $998,784 | 18,496 | $0 | 0 | +18,496 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #32 | $991,494 | 18,361 | $0 | 0 | +18,361 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #23 | $655,452 | 12,138 | $2.6M | 40,000 | -27,862-69.66% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #43 | $476,650 | 8,813 | $0 | 0 | +8,813 | New Buy |
| Persistent Asset Partners Ltd |
| 0.13% | 0.06% | #12 | $414,558 | 7,677 | $165,205 | 2,528 | +5,149+203.68% | Add |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
| <0.01% | — | #24 | $387,828 | 7,182 | $0 | 0 | +7,182 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #46 | $366,057 | 6,779 | $0 | 0 | +6,779 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #48 | $318,384 | 5,896 | $0 | 0 | +5,896 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #27 | $253,800 | 4,700 | $0 | 0 | +4,700 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #53 | $238,194 | 4,411 | $878 | 98 | +4,313+4,401.02% | Add |
| Pale Fire Capital SE |
| 0.01% | — | #18 | $206,172 | 3,818 | $0 | 0 | +3,818 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #39 | $190,026 | 3,519 | $0 | 0 | +3,519 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #49 | $143,208 | 2,652 | $0 | 0 | +2,652 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #52 | $125,766 | 2,329 | $0 | 0 | +2,329 | New Buy |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #42 | $102,600 | 1,900 | $0 | 0 | +1,900 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #51 | $68,310 | 1,265 | $61,364 | 939 | +326+34.72% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #45 | $67,608 | 1,252 | $0 | 0 | +1,252 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #58 | $62,977 | 1,127 | $0 | 0 | +1,127 | New Buy |
| Lion Point Capital, LP |
| 0.26% | 0.39% | #6 | $54,000 | 1,000 | $65,350 | 1,000 | 00.00% | Unchanged |
| Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #26 | $46,656 | 864 | $0 | 0 | +864 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #57 | $36,396 | 674 | $0 | 0 | +674 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #54 | $24,462 | 453 | $0 | 0 | +453 | New Buy |
