| TANG CAPITAL MANAGEMENT LLC |
| 1.29% | — | #4 | $28.5M | 1.6M | $0 | 0 | +1.6M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $18.4M | 1.0M | $5.9M | 764,441 | +236,844+30.98% | Add |
| PERCEPTIVE ADVISORS LLC |
| 0.28% | — | #9 | $18.4M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Soleus Capital Management, L.P. |
| 0.63% | — | #6 | $18.4M | 1.0M | $0 | 0 | +1.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $16.0M | 872,482 | $5.1M | 659,879 | +212,603+32.22% | Add |
| IRIDIAN ASSET MANAGEMENT LLC/CT |
| 4.91% | 2.04% | #1 | $14.3M | 777,078 | $5.0M | 651,757 | +125,321+19.23% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #33 | $8.0M | 432,273 | $3.0M | 384,105 | +48,168+12.54% | Add |
| Occam Crest Management LP |
| 4.06% | 1.91% | #2 | $7.4M | 357,147 | $3.1M | 407,147 | -50,000-12.28% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.92% | — | #5 | $7.0M | 382,945 | $0 | 0 | +382,945 | New Buy |
| BALDWIN WEALTH PARTNERS LLC/MA |
| 0.46% | 0.21% | #8 | $7.0M | 382,015 | $2.9M | 378,625 | +3,390+0.90% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #32 | $5.7M | 310,386 | $813,861 | 105,286 | +205,100+194.80% | Add |
| Alyeska Investment Group, L.P. |
| 0.01% | — | #20 | $5.1M | 275,000 | $0 | 0 | +275,000 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #49 | $4.6M | 248,198 | $1.3M | 166,516 | +81,682+49.05% | Add |
| Avidity Partners Management LP |
| 0.59% | — | #7 | $3.7M | 200,000 | $0 | 0 | +200,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #34 | $3.4M | 182,232 | $606,225 | 78,425 | +103,807+132.36% | Add |
| Caption Management, LLC |
| 0.01% | — | #19 | $2.9M | 160,300 | $0 | 0 | +160,300 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #38 | $2.7M | 146,714 | $960,159 | 124,212 | +22,502+18.12% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #30 | $2.3M | 127,554 | $887,729 | 114,842 | +12,712+11.07% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #44 | $2.3M | 124,282 | $142,232 | 18,400 | +105,882+575.45% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $2.2M | 118,297 | $712,350 | 92,154 | +26,143+28.37% | Add |
| Kalehua Capital Management LLC |
| 1.32% | — | #3 | $1.8M | 100,000 | $0 | 0 | +100,000 | New Buy |
| OPPENHEIMER & CO INC |
| 0.01% | 0.01% | #18 | $1.4M | 73,566 | $568,665 | 73,566 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #47 | $1.3M | 69,200 | $298,092 | 38,563 | +30,637+79.45% | Add |
| FORBES J M & CO LLP |
| 0.09% | — | #12 | $1.1M | 59,000 | $0 | 0 | +59,000 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #48 | $1.1M | 57,133 | $383,756 | 49,645 | +7,488+15.08% | Add |
| CIBC Bancorp USA Inc. |
| <0.01% | <0.01% | #24 | $917,661 | 67,155 | $198,368 | 25,662 | +41,493+161.69% | Add |
| Informed Momentum Co LLC |
| 0.08% | — | #14 | $867,420 | 47,168 | $0 | 0 | +47,168 | New Buy |
| Nuveen, LLC |
| <0.01% | <0.01% | #45 | $750,735 | 40,823 | $129,470 | 16,749 | +24,074+143.73% | Add |
| Stonepine Capital Management, LLC |
| 0.11% | — | #11 | $735,600 | 40,000 | $0 | 0 | +40,000 | New Buy |
| Squadron Capital Management LLC |
| 0.22% | — | #10 | $711,693 | 38,700 | $0 | 0 | +38,700 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #51 | $676,192 | 36,770 | $234,332 | 30,315 | +6,455+21.29% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #42 | $586,385 | 31,886 | $0 | 0 | +31,886 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #35 | $577,335 | 31,394 | $20,067 | 2,596 | +28,798+1,109.32% | Add |
| SEI INVESTMENTS CO |
| <0.01% | — | #31 | $514,240 | 27,963 | $0 | 0 | +27,963 | New Buy |
| STRS OHIO |
| <0.01% | — | #23 | $500,208 | 27,200 | $0 | 0 | +27,200 | New Buy |
| Shay Capital LLC |
| 0.02% | — | #16 | $386,190 | 21,000 | $0 | 0 | +21,000 | New Buy |
| Austin Wealth Management, LLC |
| 0.08% | 0.03% | #13 | $385,193 | 20,125 | $153,956 | 20,125 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $376,627 | 20,480 | $317,889 | 41,124 | -20,644-50.20% | Reduce |
| DAFNA Capital Management LLC |
| 0.07% | — | #15 | $367,800 | 20,000 | $0 | 0 | +20,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #71 | $344,279 | 18,721 | $111,472 | 18,517 | +204+1.10% | Add |
| MARTINGALE ASSET MANAGEMENT L P |
| 0.01% | <0.01% | #21 | $331,462 | 18,024 | $139,326 | 18,024 | 00.00% | Unchanged |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #40 | $317,606 | 17,271 | $66,914 | 8,657 | +8,614+99.50% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #55 | $310,313 | 16,874 | $97,954 | 12,672 | +4,202+33.16% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #60 | $286,774 | 15,594 | $43,435 | 5,619 | +9,975+177.52% | Add |
| Avalon Trust Co |
| 0.02% | 0.01% | #17 | $257,460 | 14,000 | $108,220 | 14,000 | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #68 | $253,874 | 13,805 | $94,000 | 12,048 | +1,757+14.58% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $218,290 | 11,870 | $114,768 | 14,847 | -2,977-20.05% | Reduce |
| Schonfeld Strategic Advisors LLC |
| <0.01% | — | #27 | $216,172 | 11,755 | $0 | 0 | +11,755 | New Buy |
| MetLife Investment Management, LLC |
| <0.01% | — | #25 | $177,500 | 9,652 | $0 | 0 | +9,652 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #80 | $148,242 | 8,061 | $58,501 | 7,568 | +493+6.51% | Add |
