| BlackRock, Inc. |
| 0.02% | 0.02% | #176 | $1.21B | 14.8M | $1.14B | 18.2M | -3.3M-18.34% | Reduce |
| Avoro Capital Advisors LLC |
| 8.31% | 6.6% | #2 | $925.6M | 11.4M | $670.9M | 10.7M | +655,556+6.13% | Add |
| FMR LLC |
| 0.03% | 0.02% | #135 | $655.3M | 8.0M | $455.6M | 7.3M | +773,152+10.64% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #151 | $517.7M | 6.4M | $448.1M | 7.1M | -794,781-11.12% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #228 | $498.1M | 6.1M | $378.2M | 6.0M | +78,537+1.30% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #197 | $464.2M | 5.7M | $407.3M | 6.5M | -801,490-12.34% | Reduce |
| NORGES BANK |
| 0.03% | <0.01% | #128 | $317.6M | 3.9M | $23.0M | 1.8M | +2.1M+116.16% | Add |
| Invesco Ltd. |
| 0.03% | 0.03% | #147 | $316.6M | 3.9M | $205.7M | 3.3M | +603,329+18.39% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #185 | $298.8M | 3.5M | $274.5M | 4.3M | -748,216-17.49% | Reduce |
| FRED ALGER MANAGEMENT, LLC |
| 0.9% | 0.92% | #21 | $269.1M | 3.3M | $209.6M | 3.3M | -40,574-1.21% | Reduce |
| BAKER BROS. ADVISORS LP |
| 0.81% | 0.72% | #22 | $162.4M | 2.0M | $124.9M | 2.0M | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #209 | $153.9M | 1.9M | $115.1M | 1.8M | +52,240+2.84% | Add |
| Siren, L.L.C. |
| 2.83% | 2.81% | #8 | $139.8M | 1.7M | $101.3M | 1.6M | +100,000+6.19% | Add |
| Vestal Point Capital, LP |
| 3% | 3.99% | #7 | $128.4M | 1.6M | $142.6M | 2.3M | -700,000-30.77% | Reduce |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.18% | 1.16% | #17 | $113.2M | 1.4M | $98.6M | 1.6M | -184,242-11.71% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.06% | 0.01% | #87 | $110.3M | 1.4M | $9.4M | 149,148 | +1.2M+807.10% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.64% | 0.55% | #25 | $110.1M | 1.4M | $74.6M | 1.2M | +160,221+13.46% | Add |
| Jupiter Topco LLC |
| 0.04% | — | #114 | $99.6M | 1.2M | $0 | 0 | +1.2M | New Buy |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #220 | $97.2M | 1.2M | $103.8M | 1.7M | -462,969-27.96% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #178 | $96.3M | 1.2M | $38.1M | 608,531 | +573,077+94.17% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #253 | $93.7M | 1.2M | $109.1M | 1.7M | -589,916-33.90% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #285 | $92.9M | 1.1M | $66.7M | 1.1M | +75,355+7.08% | Add |
| Hood River Capital Management LLC |
| 0.66% | 0.67% | #23 | $91.4M | 1.1M | $66.2M | 1.1M | +64,213+6.08% | Add |
| Holocene Advisors, LP |
| 0.2% | — | #44 | $90.2M | 1.1M | $0 | 0 | +1.1M | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #310 | $88.4M | 1.1M | $58.7M | 1.7M | -617,839-36.29% | Reduce |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.02% | #193 | $78.6M | 964,479 | $83.5M | 1.3M | -366,517-27.54% | Reduce |
| Fisher Asset Management, LLC |
| 0.02% | 0.02% | #152 | $78.1M | 957,691 | $69.8M | 1.1M | -155,877-14.00% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #235 | $75.3M | 923,927 | $74.7M | 1.2M | -268,158-22.49% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #182 | $73.1M | 896,738 | $60.6M | 965,775 | -69,037-7.15% | Reduce |
| UBS Group AG |
| 0.01% | 0.01% | #245 | $70.2M | 861,520 | $83.8M | 1.3M | -474,751-35.53% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #218 | $70.1M | 859,538 | $60.2M | 960,144 | -100,606-10.48% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #274 | $69.6M | 853,360 | $65.4M | 1.0M | -190,372-18.24% | Reduce |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.19% | 1.16% | #16 | $67.7M | 830,247 | $43.3M | 690,144 | +140,103+20.30% | Add |
| Western Financial Corp/CA |
| 19.58% | 20.13% | #1 | $66.9M | 820,239 | $51.4M | 820,239 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #357 | $51.8M | 637,399 | $39.4M | 683,068 | -45,669-6.69% | Reduce |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.1% | 0.12% | #68 | $51.0M | 625,569 | $52.5M | 836,981 | -211,412-25.26% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.03% | <0.01% | #126 | $47.3M | 580,609 | $2.9M | 45,700 | +534,909+1,170.48% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.08% | #110 | $46.7M | 573,419 | $79.6M | 1.3M | -699,847-54.96% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.02% | #159 | $45.5M | 558,643 | $40.8M | 650,599 | -91,956-14.13% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.13% | 0.06% | #57 | $44.1M | 540,466 | $19.6M | 312,824 | +227,642+72.77% | Add |
| 1832 Asset Management L.P. |
| 0.02% | — | #157 | $43.9M | 538,500 | $0 | 0 | +538,500 | New Buy |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.02% | 0.02% | #164 | $41.9M | 514,658 | $30.7M | 490,122 | +24,536+5.01% | Add |
| HRT FINANCIAL LP |
| 0.07% | <0.01% | #79 | $40.6M | 498,655 | $620,000 | 9,900 | +488,755+4,936.92% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.04% | #127 | $39.4M | 483,495 | $41.1M | 656,129 | -172,634-26.31% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.05% | 0.02% | #105 | $38.4M | 470,754 | $12.9M | 206,412 | +264,342+128.07% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.1% | #100 | $38.2M | 468,921 | $65.0M | 1.0M | -567,574-54.76% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #262 | $37.7M | 462,133 | $29.0M | 462,707 | -574-0.12% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #354 | $35.3M | 433,005 | $17.9M | 285,075 | +147,930+51.89% | Add |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.04% | #179 | $35.2M | 431,560 | $74.8M | 1.2M | -761,278-63.82% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.01% | #255 | $33.9M | 415,883 | $31.3M | 499,837 | -83,954-16.80% | Reduce |
