| Boxer Capital Management, LLC |
| 0.59% | — | #4 | $7.9M | 560,000 | $0 | 0 | +560,000 | New Buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO |
| 0.07% | 0.02% | #7 | $5.8M | 414,958 | $1.1M | 142,469 | +272,489+191.26% | Add |
| Bleichroeder LP |
| 1.01% | 0.51% | #2 | $5.6M | 400,000 | $3.0M | 400,000 | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.59% | — | #5 | $5.6M | 396,201 | $0 | 0 | +396,201 | New Buy |
| Dauntless Investment Group, LLC |
| 3.92% | 0.39% | #1 | $5.0M | 354,208 | $593,950 | 79,832 | +274,376+343.69% | Add |
| Stonepine Capital Management, LLC |
| 0.74% | 1.03% | #3 | $4.9M | 345,179 | $2.6M | 345,179 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #21 | $4.7M | 332,916 | $0 | 0 | +332,916 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #16 | $2.3M | 200,300 | $1.5M | 200,000 | +300+0.15% | Add |
| Ensign Peak Advisors, Inc |
| <0.01% | — | #15 | $1.6M | 110,778 | $0 | 0 | +110,778 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #24 | $1.5M | 104,509 | $0 | 0 | +104,509 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #20 | $1.4M | 101,376 | $0 | 0 | +101,376 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #27 | $1.3M | 93,140 | $0 | 0 | +93,140 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #26 | $1.1M | 81,090 | $103,668 | 13,934 | +67,156+481.96% | Add |
| J. Goldman & Co LP |
| 0.02% | — | #9 | $964,353 | 68,491 | $0 | 0 | +68,491 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.04% | — | #8 | $866,624 | 61,550 | $0 | 0 | +61,550 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #25 | $802,546 | 56,999 | $178,553 | 23,999 | +33,000+137.51% | Add |
| COOPERMAN LEON G |
| 0.02% | — | #11 | $704,000 | 50,000 | $0 | 0 | +50,000 | New Buy |
| Westside Investment Management, Inc. |
| 0.09% | 0.06% | #6 | $669,997 | 47,585 | $375,162 | 50,425 | -2,840-5.63% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #30 | $656,212 | 46,606 | $1,442 | 200 | +46,406+23,203.00% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #19 | $622,772 | 44,231 | $0 | 0 | +44,231 | New Buy |
| XTX Topco Ltd |
| 0.01% | — | #12 | $439,099 | 31,186 | $0 | 0 | +31,186 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #23 | $423,667 | 30,090 | $8,043 | 1,081 | +29,009+2,683.53% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #28 | $338,194 | 24,599 | $117,173 | 15,749 | +8,850+56.19% | Add |
| Sequoia Financial Advisors, LLC |
| <0.01% | <0.01% | #17 | $281,643 | 20,003 | $446,400 | 60,000 | -39,997-66.66% | Reduce |
| Engineers Gate Manager LP |
| <0.01% | — | #14 | $210,848 | 14,975 | $0 | 0 | +14,975 | New Buy |
| Laird Norton Wetherby Trust Company, LLC |
| <0.01% | <0.01% | #13 | $181,632 | 12,900 | $92,256 | 12,400 | +500+4.03% | Add |
| UNITED BANK |
| 0.02% | — | #10 | $180,941 | 12,851 | $0 | 0 | +12,851 | New Buy |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #22 | $178,816 | 12,700 | $94,488 | 12,700 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | — | #33 | $41,399 | 2,863 | $0 | 0 | +2,863 | New Buy |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #18 | $27,118 | 1,926 | $11,666 | 1,568 | +358+22.83% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #31 | $18,245 | 1,296 | $10,428 | 1,402 | -106-7.56% | Reduce |
| Arax Advisory Partners |
| <0.01% | — | #32 | $1,225 | 87 | $0 | 0 | +87 | New Buy |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #29 | $338 | 24 | $0 | 0 | +24 | New Buy |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #34 | $282 | 20 | $0 | 0 | +20 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #35 | $140 | 10 | $65,048 | 8,744 | -8,734-99.89% | Reduce |
| Allworth Financial LP |
| <0.01% | <0.01% | #36 | $15 | 1 | $8 | 1 | 00.00% | Unchanged |
