| Stonepine Capital Management, LLC |
| 0.31% | 0.14% | #2 | $2.0M | 765,546 | $352,836 | 53,460 | +712,086+1,332.00% | Add |
| Dauntless Investment Group, LLC |
| 0.82% | 0.86% | #1 | $1.0M | 214,987 | $1.3M | 196,592 | +18,395+9.36% | Add |
| Ikarian Capital, LLC |
| 0.11% | 0.11% | #3 | $1.0M | 211,538 | $1.4M | 211,538 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #13 | $543,643 | 112,323 | $503,230 | 76,247 | +36,076+47.31% | Add |
| SummitTX Capital, L.P. |
| 0.01% | 0.02% | #7 | $485,452 | 100,300 | $661,980 | 100,300 | 00.00% | Unchanged |
| Woodline Partners LP |
| <0.01% | <0.01% | #10 | $369,999 | 76,446 | $525,241 | 79,582 | -3,136-3.94% | Reduce |
| Aberdeen Group plc |
| <0.01% | <0.01% | #12 | $363,000 | 75,000 | $495,000 | 75,000 | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.01% | 0.02% | #8 | $352,013 | 72,730 | $480,018 | 72,730 | 00.00% | Unchanged |
| AIGH Capital Management LLC |
| 0.02% | 0.05% | #6 | $338,800 | 70,000 | $336,600 | 51,000 | +19,000+37.25% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | 0.01% | #9 | $289,616 | 59,838 | $394,931 | 59,838 | 00.00% | Unchanged |
| Velan Capital Investment Management LP |
| 0.1% | 0.35% | #4 | $156,680 | 32,372 | $560,003 | 84,849 | -52,477-61.85% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #16 | $103,910 | 21,469 | $8,580 | 1,300 | +20,169+1,551.46% | Add |
| Birchview Capital, LP |
| 0.04% | 0.08% | #5 | $96,800 | 20,000 | $132,000 | 20,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #11 | $72,629 | 15,006 | $0 | 0 | +15,006 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #19 | $38,720 | 8,000 | $0 | 0 | +8,000 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #18 | $32,777 | 6,772 | $16,579 | 2,512 | +4,260+169.59% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #17 | $11,280 | 2,332 | $10,033 | 1,521 | +811+53.32% | Add |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #14 | $2,125 | 439 | $11,352 | 1,720 | -1,281-74.48% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #15 | $1,718 | 355 | $13 | 2 | +353+17,650.00% | Add |
