| MPM BioImpact LLC |
| 3.67% | 8.41% | #1 | $60.1M | 3.7M | $108.9M | 5.2M | -1.5M-29.68% | Reduce |
| Siren, L.L.C. |
| 0.62% | 1.08% | #10 | $30.5M | 1.9M | $38.8M | 1.9M | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 2.76% | 4.63% | #2 | $30.3M | 1.8M | $55.7M | 2.7M | -822,811-30.84% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 0.41% | 0.39% | #13 | $27.1M | 1.7M | $20.1M | 964,391 | +688,959+71.44% | Add |
| BAKER BROS. ADVISORS LP |
| 0.12% | 0.18% | #17 | $24.0M | 1.5M | $30.5M | 1.5M | 00.00% | Unchanged |
| Artisan Partners Limited Partnership |
| 0.04% | 0.07% | #23 | $22.5M | 1.4M | $46.4M | 2.2M | -846,535-38.14% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $21.5M | 1.3M | $1.7M | 79,537 | +1.2M+1,551.36% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #41 | $15.7M | 954,908 | $84,640 | 8,464 | +946,444+11,181.99% | Add |
| Logos Global Management LP |
| 0.65% | — | #9 | $15.0M | 915,000 | $0 | 0 | +915,000 | New Buy |
| Patient Square Capital LP |
| 2.31% | 2.57% | #3 | $14.9M | 909,474 | $14.5M | 693,534 | +215,940+31.14% | Add |
| Octagon Capital Advisors LP |
| 0.85% | 1.33% | #8 | $9.4M | 574,200 | $12.0M | 574,200 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.4% | 1.25% | #14 | $8.7M | 528,295 | $21.2M | 1.0M | -484,571-47.84% | Reduce |
| Ikarian Capital, LLC |
| 0.89% | 0.18% | #7 | $8.4M | 525,000 | $2.2M | 525,000 | 00.00% | Unchanged |
| Redmile Group, LLC |
| 0.45% | 0.68% | #12 | $6.7M | 410,440 | $10.3M | 491,340 | -80,900-16.47% | Reduce |
| Duquesne Family Office LLC |
| 0.12% | 0.24% | #16 | $6.3M | 383,363 | $8.0M | 383,363 | 00.00% | Unchanged |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #38 | $6.2M | 378,497 | $4.8M | 231,417 | +147,080+63.56% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $4.4M | 267,783 | $6.7M | 318,959 | -51,176-16.04% | Reduce |
| Elmind Capital, LP |
| 1.09% | 1.57% | #5 | $4.3M | 265,000 | $5.5M | 265,000 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #48 | $3.7M | 223,915 | $235,744 | 11,285 | +212,630+1,884.18% | Add |
| Ishara Investments LP |
| 2.19% | 2.03% | #4 | $3.0M | 184,500 | $2.1M | 102,500 | +82,000+80.00% | Add |
| Yiheng Capital Management, L.P. |
| 1.03% | 1.54% | #6 | $2.8M | 170,142 | $3.6M | 170,142 | 00.00% | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | 0.04% | #22 | $2.7M | 163,401 | $3.4M | 163,401 | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 0.49% | — | #11 | $2.6M | 156,906 | $0 | 0 | +156,906 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #30 | $2.5M | 151,197 | $503,000 | 24,085 | +127,112+527.76% | Add |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | <0.01% | #33 | $2.0M | 119,335 | $3.5M | 168,180 | -48,845-29.04% | Reduce |
| ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #45 | $1.9M | 113,823 | $2.0M | 95,714 | +18,109+18.92% | Add |
| XTX Topco Ltd |
| 0.02% | 0.02% | #25 | $1.5M | 91,202 | $878,529 | 42,055 | +49,147+116.86% | Add |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #39 | $1.4M | 84,196 | $2.7M | 128,560 | -44,364-34.51% | Reduce |
| DIVERSIFY WEALTH MANAGEMENT, LLC |
| 0.01% | 0.02% | #26 | $1.2M | 89,692 | $1.3M | 63,672 | +26,020+40.87% | Add |
| Dorsey Wright & Associates |
| 0.2% | 0.27% | #15 | $1.2M | 73,115 | $2.1M | 102,550 | -29,435-28.70% | Reduce |
| Polymer Capital Management (HK) LTD |
| 0.05% | 0.12% | #21 | $1.1M | 64,500 | $1.3M | 64,500 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #49 | $971,536 | 59,240 | $0 | 0 | +59,240 | New Buy |
| LPL Financial LLC |
| <0.01% | <0.01% | #51 | $881,516 | 53,751 | $1.2M | 55,871 | -2,120-3.79% | Reduce |
| AdvisorShares Investments LLC |
| 0.09% | 0.19% | #19 | $716,073 | 43,663 | $1.1M | 50,340 | -6,677-13.26% | Reduce |
| Cetera Investment Advisers |
| <0.01% | <0.01% | #44 | $578,215 | 35,257 | $529,729 | 25,358 | +9,899+39.04% | Add |
| Engineers Gate Manager LP |
| 0.01% | 0.01% | #29 | $532,000 | 32,439 | $690,205 | 33,040 | -601-1.82% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #46 | $472,402 | 28,805 | $781,850 | 37,427 | -8,622-23.04% | Reduce |
| STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $452,774 | 27,608 | $642,076 | 30,736 | -3,128-10.18% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #61 | $373,625 | 22,782 | $0 | 0 | +22,782 | New Buy |
| Burns Matteson Capital Management, LLC |
| 0.11% | 0.17% | #18 | $357,815 | 21,818 | $472,762 | 22,631 | -813-3.59% | Reduce |
| Atria Investments, Inc |
| <0.01% | <0.01% | #31 | $309,993 | 18,902 | $441,510 | 21,135 | -2,233-10.57% | Reduce |
| Persistent Asset Partners Ltd |
| 0.08% | 0.09% | #20 | $256,332 | 15,630 | $237,979 | 11,392 | +4,238+37.20% | Add |
| PERSONAL CFO SOLUTIONS, LLC |
| 0.03% | 0.04% | #24 | $212,216 | 12,940 | $264,112 | 12,643 | +297+2.35% | Add |
| Point72 Asset Management, L.P. |
| <0.01% | — | #50 | $199,227 | 12,148 | $0 | 0 | +12,148 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #53 | $190,732 | 11,630 | $0 | 0 | +11,630 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #71 | $189,813 | 11,574 | $0 | 0 | +11,574 | New Buy |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #52 | $177,268 | 10,809 | $350,200 | 16,764 | -5,955-35.52% | Reduce |
| Integrated Wealth Concepts LLC |
| <0.01% | <0.01% | #40 | $170,053 | 10,369 | $221,057 | 10,582 | -213-2.01% | Reduce |
| China Universal Asset Management Co., Ltd. |
| 0.01% | 0.01% | #28 | $131,200 | 8,000 | $104,450 | 5,000 | +3,000+60.00% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $118,047 | 7,198 | $168,770 | 8,079 | -881-10.90% | Reduce |
