| BlackRock, Inc. |
| 0.03% | 0.02% | #182 | $1.71B | 20.1M | $1.09B | 16.5M | +3.5M+21.43% | Add |
| T. Rowe Price Investment Management, Inc. |
| 1.05% | 0.8% | #35 | $1.59B | 18.7M | $1.15B | 17.5M | +1.2M+6.82% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.1% | 0.1% | #106 | $590.5M | 6.9M | $527.9M | 8.0M | -1.1M-13.46% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.02% | #178 | $571.8M | 6.7M | $385.2M | 5.8M | +868,017+14.85% | Add |
| STATE STREET CORP |
| 0.02% | 0.01% | #213 | $553.2M | 6.5M | $378.7M | 5.7M | +749,040+13.04% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #243 | $521.2M | 6.1M | $361.8M | 5.5M | +628,881+11.46% | Add |
| FMR LLC |
| 0.02% | 0.04% | #205 | $428.7M | 5.0M | $706.8M | 10.7M | -5.7M-53.08% | Reduce |
| Avoro Capital Advisors LLC |
| 3.82% | 2.16% | #10 | $425.9M | 5.0M | $219.7M | 3.3M | +1.7M+50.00% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.03% | 0.01% | #181 | $394.9M | 4.6M | $206.0M | 3.1M | +1.5M+48.32% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.02% | #185 | $317.7M | 3.7M | $146.5M | 2.2M | +1.5M+67.79% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.01% | #211 | $316.3M | 3.7M | $212.0M | 3.2M | +497,086+15.46% | Add |
| RTW INVESTMENTS, LP |
| 2.08% | 1.78% | #21 | $243.8M | 2.9M | $179.4M | 2.7M | +140,845+5.18% | Add |
| ARMISTICE CAPITAL, LLC |
| 2.85% | 3.12% | #14 | $232.7M | 2.7M | $175.6M | 2.7M | +66,804+2.51% | Add |
| Polar Capital Holdings Plc |
| 0.45% | 0.39% | #54 | $192.0M | 2.3M | $109.5M | 1.7M | +592,401+35.66% | Add |
| CITADEL ADVISORS LLC |
| 0.02% | 0.02% | #203 | $167.5M | 2.0M | $102.4M | 1.6M | +412,387+26.53% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #212 | $166.9M | 2.0M | $104.4M | 1.6M | +374,625+23.65% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #229 | $152.9M | 1.8M | $161.9M | 2.5M | -661,070-26.92% | Reduce |
| Capital Research Global Investors |
| 0.02% | 0.01% | #196 | $143.7M | 1.7M | $50.8M | 770,999 | +915,626+118.76% | Add |
| NORTHERN TRUST CORP |
| 0.02% | 0.01% | #214 | $140.3M | 1.6M | $95.0M | 1.4M | +205,711+14.27% | Add |
| JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #281 | $139.2M | 1.6M | $56.9M | 903,805 | +685,090+75.80% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.41% | 0.24% | #59 | $136.6M | 1.6M | $71.7M | 1.1M | +515,851+47.43% | Add |
| Integral Health Asset Management, LLC |
| 5.38% | 8.2% | #6 | $136.3M | 1.6M | $171.4M | 2.6M | -1.0M-38.46% | Reduce |
| Point72 Asset Management, L.P. |
| 0.15% | 0.06% | #94 | $135.3M | 1.6M | $43.6M | 661,002 | +927,310+140.29% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #208 | $133.4M | 1.6M | $92.1M | 1.4M | +168,736+12.08% | Add |
| MORGAN STANLEY |
| 0.01% | 0.01% | #288 | $128.7M | 1.5M | $83.6M | 1.5M | -10,868-0.71% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.05% | 0.04% | #140 | $111.7M | 1.3M | $72.1M | 1.1M | +218,179+19.95% | Add |
| Capital International Investors |
| 0.02% | 0.02% | #189 | $111.2M | 1.3M | $88.2M | 1.3M | -32,955-2.46% | Reduce |
| Invesco Ltd. |
| 0.01% | <0.01% | #274 | $105.2M | 1.2M | $32.0M | 484,980 | +750,343+154.72% | Add |
| UBS Group AG |
| 0.01% | 0.02% | #232 | $99.8M | 1.2M | $138.6M | 2.1M | -930,890-44.28% | Reduce |
| Pictet Asset Management Holding SA |
| 0.09% | 0.05% | #109 | $99.0M | 1.2M | $49.3M | 750,953 | +409,510+54.53% | Add |
| Frazier Life Sciences Management, L.P. |
| 2.15% | 1.97% | #17 | $98.8M | 1.2M | $76.4M | 1.2M | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| 0.02% | 0.01% | #216 | $98.0M | 1.2M | $66.3M | 1.0M | +144,512+14.36% | Add |
| Holocene Advisors, LP |
| 0.22% | — | #78 | $97.5M | 1.1M | $0 | 0 | +1.1M | New Buy |
| Woodline Partners LP |
| 0.29% | 0.25% | #72 | $93.8M | 1.1M | $65.9M | 1.0M | +100,280+10.02% | Add |
| D. E. Shaw & Co., Inc. |
| 0.04% | 0.03% | #149 | $89.3M | 1.0M | $49.3M | 747,331 | +300,772+40.25% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #271 | $86.5M | 1.0M | $47.3M | 1.2M | -161,397-13.71% | Reduce |
| Royalty Pharma Sub-Manager, LLC |
| 34.52% | 37.4% | #1 | $83.5M | 980,392 | $64.6M | 980,392 | 00.00% | Unchanged |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.12% | 0.01% | #100 | $81.9M | 961,815 | $3.2M | 48,483 | +913,332+1,883.82% | Add |
| GW&K Investment Management, LLC |
| 0.61% | 0.29% | #48 | $78.0M | 916,107 | $32.6M | 494,619 | +421,488+85.21% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #209 | $77.2M | 906,423 | $52.7M | 799,622 | +106,801+13.36% | Add |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.01% | #217 | $75.9M | 891,087 | $27.0M | 409,784 | +481,303+117.45% | Add |
| JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #299 | $72.9M | 855,584 | $21.2M | 321,797 | +533,787+165.88% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.07% | — | #128 | $70.5M | 827,810 | $0 | 0 | +827,810 | New Buy |
| Melqart Asset Management (UK) Ltd |
| 6.22% | 5.48% | #5 | $65.4M | 767,525 | $55.6M | 843,949 | -76,424-9.06% | Reduce |
| Siren, L.L.C. |
| 1.31% | 1.12% | #30 | $64.7M | 758,952 | $40.5M | 613,952 | +145,000+23.62% | Add |
| GROUP ONE TRADING LLC |
| 0.09% | 0.05% | #116 | $64.0M | 751,500 | $24.0M | 363,997 | +387,503+106.46% | Add |
| Fisher Asset Management, LLC |
| 0.02% | 0.02% | #204 | $63.4M | 743,697 | $50.6M | 768,264 | -24,567-3.20% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.08% | 0.09% | #124 | $62.3M | 731,076 | $72.4M | 1.1M | -367,069-33.43% | Reduce |
| Foresite Capital Management IV, LLC |
| 20.98% | 13.99% | #2 | $60.9M | 714,695 | $33.2M | 503,295 | +211,400+42.00% | Add |
| Deep Track Capital, LP |
| 0.87% | 1.48% | #41 | $59.6M | 700,000 | $90.6M | 1.4M | -674,320-49.07% | Reduce |
