| BVF INC/IL |
| 0.17% | 0.18% | #8 | $6.5M | 1.1M | $5.6M | 1.1M | 00.00% | Unchanged |
| Blue Owl Capital Holdings LP |
| 0.79% | 1.29% | #4 | $5.4M | 917,692 | $4.8M | 959,337 | -41,645-4.34% | Reduce |
| ORBIMED ADVISORS LLC |
| 0.1% | 0.04% | #10 | $5.4M | 909,269 | $1.9M | 378,556 | +530,713+140.19% | Add |
| Cable Car Capital, LP |
| 1.23% | 1.25% | #3 | $3.8M | 754,749 | $3.8M | 754,749 | 00.00% | Unchanged |
| Omega Fund Management, LLC |
| 1.45% | 1.4% | #2 | $2.7M | 455,361 | $2.3M | 455,361 | 00.00% | Unchanged |
| RTW INVESTMENTS, LP |
| 0.02% | 0.02% | #14 | $2.0M | 334,445 | $1.7M | 334,445 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $1.9M | 320,518 | $1.6M | 325,155 | -4,637-1.43% | Reduce |
| Trails Edge Capital Partners, LP |
| 0.26% | — | #6 | $1.7M | 282,004 | $0 | 0 | +282,004 | New Buy |
| BML Capital Management, LLC |
| 0.68% | 0.64% | #5 | $1.2M | 200,730 | $1.0M | 200,730 | 00.00% | Unchanged |
| Monashee Investment Management LLC |
| 1.9% | — | #1 | $1.1M | 192,344 | $0 | 0 | +192,344 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $797,030 | 135,090 | $646,070 | 129,214 | +5,876+4.55% | Add |
| Stonepine Capital Management, LLC |
| 0.08% | — | #11 | $539,044 | 96,172 | $0 | 0 | +96,172 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #17 | $512,887 | 86,930 | $408,480 | 81,696 | +5,234+6.41% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #18 | $393,329 | 66,666 | $333,330 | 66,666 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #24 | $328,099 | 55,610 | $621,725 | 124,345 | -68,735-55.28% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $315,755 | 53,512 | $299,672 | 59,929 | -6,417-10.71% | Reduce |
| NEA Management Company, LLC |
| 0.02% | 0.01% | #13 | $295,030 | 50,005 | $250,025 | 50,005 | 00.00% | Unchanged |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.23% | 0.14% | #7 | $295,000 | 50,000 | $150,000 | 30,000 | +20,000+66.67% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #21 | $208,449 | 34,228 | $165,699 | 34,884 | -656-1.88% | Reduce |
| Sofinnova Investments, Inc. |
| 0.01% | 0.01% | #15 | $188,116 | 31,884 | $159,420 | 31,884 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #25 | $162,103 | 27,475 | $136,430 | 27,286 | +189+0.69% | Add |
| Rangeley Capital, LLC |
| 0.11% | 0.16% | #9 | $118,531 | 20,090 | $162,950 | 32,590 | -12,500-38.36% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #22 | $117,410 | 19,900 | $0 | 0 | +19,900 | New Buy |
| Aldebaran Capital, LLC |
| 0.08% | 0.07% | #12 | $106,932 | 18,124 | $92,830 | 18,566 | -442-2.38% | Reduce |
| Shay Capital LLC |
| 0.01% | 0.01% | #16 | $106,672 | 18,080 | $95,650 | 19,130 | -1,050-5.49% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #31 | $98,400 | 16,678 | $10,481 | 1,286 | +15,392+1,196.89% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #29 | $91,362 | 15,485 | $57,290 | 11,458 | +4,027+35.15% | Add |
| NORTHERN TRUST CORP |
| <0.01% | — | #30 | $66,499 | 11,271 | $0 | 0 | +11,271 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #27 | $63,702 | 10,797 | $54,795 | 10,959 | -162-1.48% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $40,586 | 6,879 | $27,140 | 5,428 | +1,451+26.73% | Add |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #20 | $3,983 | 675 | $5,055 | 1,011 | -336-33.23% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #34 | $3,552 | 602 | $3,010 | 602 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #19 | $2,738 | 464 | $10 | 2 | +462+23,100.00% | Add |
| NewEdge Advisors, LLC |
| <0.01% | <0.01% | #33 | $944 | 160 | $800 | 160 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #36 | $425 | 70 | $1,465 | 293 | -223-76.11% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #35 | $142 | 24 | $120 | 24 | 00.00% | Unchanged |
