| ORBIMED ADVISORS LLC |
| 0.02% | 0.02% | #7 | $1.0M | 1.2M | $1.1M | 605,531 | +597,729+98.71% | Add |
| Ally Bridge Group (NY) LLC |
| 0.59% | — | #1 | $663,033 | 786,236 | $0 | 0 | +786,236 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #10 | $615,609 | 730,000 | $1.3M | 730,000 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.02% | #6 | $504,065 | 597,729 | $281,999 | 154,098 | +443,631+287.89% | Add |
| Lynx1 Capital Management LP |
| 0.09% | <0.01% | #2 | $471,801 | 559,470 | $27,593 | 15,078 | +544,392+3,610.51% | Add |
| Ikarian Capital, LLC |
| 0.04% | 0.1% | #5 | $403,217 | 478,142 | $1.2M | 678,142 | -200,000-29.49% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.04% | — | #4 | $336,043 | 398,486 | $0 | 0 | +398,486 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $278,231 | 330,049 | $101,003 | 55,193 | +274,856+497.99% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #18 | $182,158 | 216,006 | $38,871 | 21,241 | +194,765+916.93% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | — | #11 | $138,618 | 164,376 | $0 | 0 | +164,376 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #9 | $112,948 | 133,936 | $356,001 | 194,536 | -60,600-31.15% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $93,915 | 111,365 | $141,100 | 77,103 | +34,262+44.44% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #14 | $76,926 | 91,220 | $0 | 0 | +91,220 | New Buy |
| Kynam Capital Management, LP |
| <0.01% | — | #8 | $71,175 | 84,400 | $0 | 0 | +84,400 | New Buy |
| Dauntless Investment Group, LLC |
| 0.05% | 0.51% | #3 | $67,948 | 80,574 | $763,106 | 416,998 | -336,424-80.68% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #19 | $45,953 | 54,511 | $58,201 | 31,804 | +22,707+71.40% | Add |
| NORTHERN TRUST CORP |
| <0.01% | — | #23 | $31,585 | 37,454 | $0 | 0 | +37,454 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #25 | $21,759 | 25,802 | $47,218 | 25,802 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #13 | $15,257 | 18,092 | $0 | 0 | +18,092 | New Buy |
| SG Americas Securities, LLC |
| <0.01% | — | #20 | $12,248 | 14,524 | $0 | 0 | +14,524 | New Buy |
| Virtu Financial LLC |
| <0.01% | — | #12 | $10,608 | 12,579 | $0 | 0 | +12,579 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $8,383 | 9,941 | $18,219 | 9,956 | -15-0.15% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #15 | $4,336 | 5,142 | $7,254 | 3,964 | +1,178+29.72% | Add |
| HUNTINGTON NATIONAL BANK |
| <0.01% | — | #17 | $3,943 | 4,676 | $0 | 0 | +4,676 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #26 | $2,909 | 3,451 | $7,417 | 4,053 | -602-14.85% | Reduce |
| BARCLAYS PLC |
| <0.01% | — | #27 | $1,642 | 1,947 | $0 | 0 | +1,947 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #16 | $1,451 | 1,721 | $234 | 128 | +1,593+1,244.53% | Add |
| Federation des caisses Desjardins du Quebec |
| <0.01% | — | #24 | $414 | 500 | $0 | 0 | +500 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #31 | $395 | 468 | $1,330 | 719 | -251-34.91% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #30 | $221 | 262 | $479 | 262 | 00.00% | Unchanged |
| Cassaday & Co Wealth Management LLC |
| <0.01% | <0.01% | #29 | $6 | 6 | $21 | 11 | -5-45.45% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #33 | $2 | 2 | $42 | 23 | -21-91.30% | Reduce |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #33 | $2 | 2 | $4 | 2 | 00.00% | Unchanged |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #32 | $2 | 2 | $0 | 0 | +2 | New Buy |
