| PERCEPTIVE ADVISORS LLC |
| 0.1% | 0.22% | #1 | $6.4M | 9.9M | $11.0M | 9.9M | +10+0.00% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #9 | $820,039 | 1.3M | $1.4M | 1.3M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.04% | 0.08% | #3 | $785,469 | 1.2M | $1.4M | 1.2M | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #7 | $755,605 | 1.2M | $1.3M | 1.2M | 00.00% | Unchanged |
| Sio Capital Management, LLC |
| 0.08% | 0.21% | #2 | $455,461 | 698,989 | $1.5M | 1.3M | -589,472-45.75% | Reduce |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.03% | #4 | $146,193 | 224,360 | $289,768 | 251,972 | -27,612-10.96% | Reduce |
| Shaolin Capital Management LLC |
| 0.01% | 0.01% | #5 | $111,534 | 171,170 | $196,846 | 171,170 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $71,038 | 108,954 | $45,549 | 39,608 | +69,346+175.08% | Add |
| Affinity Asset Advisors, LLC |
| <0.01% | <0.01% | #6 | $52,128 | 80,000 | $92,000 | 80,000 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $51,550 | 79,115 | $144,027 | 125,241 | -46,126-36.83% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #15 | $35,066 | 53,782 | $61,849 | 53,782 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #18 | $20,118 | 30,875 | $24,838 | 21,598 | +9,277+42.95% | Add |
| TORONTO DOMINION BANK |
| <0.01% | <0.01% | #13 | $16,300 | 25,000 | $28,750 | 25,000 | 00.00% | Unchanged |
| Opaleye Management Inc. |
| <0.01% | <0.01% | #8 | $13,353 | 18,444 | $21,211 | 18,444 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | <0.01% | #10 | $11,828 | 18,153 | $26,853 | 23,350 | -5,197-22.26% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #20 | $10,527 | 16,155 | $0 | 0 | +16,155 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #14 | $8,930 | 13,705 | $0 | 0 | +13,705 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #16 | $8,637 | 13,255 | $1 | 1 | +13,254+1,325,400.00% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #21 | $7,507 | 11,531 | $14,786 | 12,857 | -1,326-10.31% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #11 | $4,205 | 6,454 | $2,532 | 2,202 | +4,252+193.10% | Add |
| UBS Group AG |
| <0.01% | — | #22 | $1,479 | 2,268 | $0 | 0 | +2,268 | New Buy |
| Crewe Advisors LLC |
| <0.01% | <0.01% | #12 | $326 | 500 | $575 | 500 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | — | #23 | $89 | 137 | $0 | 0 | +137 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #24 | $15 | 23 | $0 | 0 | +23 | New Buy |
