| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #17 | $7.2M | 938,666 | $5.3M | 938,666 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.14% | 0.14% | #7 | $6.9M | 892,074 | $5.0M | 892,074 | 00.00% | Unchanged |
| Vivo Capital, LLC |
| 0.58% | 0.38% | #3 | $6.3M | 813,666 | $4.6M | 813,666 | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #15 | $5.3M | 682,700 | $3.9M | 690,778 | -8,078-1.17% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.66% | 0.44% | #2 | $5.1M | 652,590 | $2.8M | 489,207 | +163,383+33.40% | Add |
| Woodline Partners LP |
| 0.01% | 0.01% | #13 | $3.9M | 500,432 | $2.8M | 500,432 | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 0.57% | 0.23% | #4 | $3.7M | 491,624 | $563,000 | 100,000 | +391,624+391.62% | Add |
| MONTANOVA CAPITAL, LLC |
| 0.07% | 0.07% | #12 | $3.7M | 475,000 | $2.7M | 475,000 | 00.00% | Unchanged |
| Avidity Partners Management LP |
| 0.48% | 0.44% | #5 | $3.0M | 387,769 | $2.2M | 387,769 | 00.00% | Unchanged |
| Saturn V Capital Management LP |
| 0.39% | 0.36% | #6 | $2.7M | 350,000 | $2.0M | 350,000 | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.08% | 0.09% | #10 | $2.4M | 314,359 | $2.3M | 414,359 | -100,000-24.13% | Reduce |
| 683 Capital Management, LLC |
| 0.09% | 0.07% | #9 | $1.8M | 230,833 | $1.3M | 230,833 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.08% | 0.07% | #11 | $1.7M | 222,555 | $1.3M | 222,555 | 00.00% | Unchanged |
| AWM Investment Company, Inc. |
| 0.12% | — | #8 | $1.4M | 180,000 | $0 | 0 | +180,000 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $1.2M | 152,768 | $1.7M | 298,433 | -145,665-48.81% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #16 | $1.2M | 150,000 | $2.1M | 380,354 | -230,354-60.56% | Reduce |
| Empery Asset Management, LP |
| 0.96% | 1.56% | #1 | $832,703 | 107,100 | $1.3M | 230,100 | -123,000-53.46% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #19 | $526,663 | 67,738 | $239,230 | 42,492 | +25,246+59.41% | Add |
| MORGAN STANLEY |
| <0.01% | — | #21 | $200,066 | 25,732 | $0 | 0 | +25,732 | New Buy |
| China Universal Asset Management Co., Ltd. |
| 0.01% | <0.01% | #14 | $155,500 | 20,000 | $36,032 | 6,400 | +13,600+212.50% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #20 | $124,000 | 15,863 | $91,000 | 16,245 | -382-2.35% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $92,576 | 11,907 | $67,036 | 11,907 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #24 | $6,073 | 781 | $158 | 28 | +753+2,689.29% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | — | #26 | $2,485 | 315 | $0 | 0 | +315 | New Buy |
| Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #25 | $143 | 19 | $106 | 19 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #23 | $8 | 1 | $6 | 1 | 00.00% | Unchanged |
