| Jupiter Topco LLC |
| 0.01% | — | #14 | $17.0M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Deep Track Capital, LP |
| 0.16% | 0.17% | #8 | $11.0M | 835,655 | $10.6M | 835,655 | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #16 | $9.2M | 696,378 | $8.8M | 696,378 | 00.00% | Unchanged |
| Ally Bridge Group (NY) LLC |
| 7.22% | 4.25% | #1 | $8.2M | 620,319 | $5.3M | 414,219 | +206,100+49.76% | Add |
| Trails Edge Capital Partners, LP |
| 1.16% | 1.62% | #4 | $7.3M | 557,103 | $7.1M | 557,103 | 00.00% | Unchanged |
| Woodline Partners LP |
| 0.02% | 0.02% | #12 | $5.8M | 441,911 | $5.0M | 395,295 | +46,616+11.79% | Add |
| Yu Fan |
| 4.02% | 4.32% | #2 | $4.3M | 329,760 | $4.2M | 329,760 | 00.00% | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.56% | 0.66% | #5 | $4.3M | 325,591 | $4.1M | 325,591 | 00.00% | Unchanged |
| Squadron Capital Management LLC |
| 1.33% | 1.51% | #3 | $4.3M | 324,977 | $4.1M | 324,977 | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.29% | 0.06% | #6 | $2.7M | 205,000 | $698,500 | 55,000 | +150,000+272.73% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | — | #17 | $2.4M | 185,700 | $0 | 0 | +185,700 | New Buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #15 | $2.2M | 164,275 | $1.8M | 139,275 | +25,000+17.95% | Add |
| 683 Capital Management, LLC |
| 0.06% | 0.06% | #9 | $1.3M | 95,000 | $1.2M | 92,850 | +2,150+2.32% | Add |
| ADAR1 Capital Management, LLC |
| 0.06% | 0.07% | #10 | $1.2M | 92,850 | $1.2M | 95,350 | -2,500-2.62% | Reduce |
| GREAT POINT PARTNERS LLC |
| 0.21% | 1.08% | #7 | $1.1M | 86,150 | $4.7M | 371,402 | -285,252-76.80% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | <0.01% | #13 | $816,946 | 62,078 | $203,746 | 16,043 | +46,035+286.95% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $737,552 | 56,045 | $989,597 | 77,921 | -21,876-28.07% | Reduce |
| BANK OF MONTREAL /CAN/ |
| <0.01% | — | #19 | $149,642 | 11,371 | $0 | 0 | +11,371 | New Buy |
| Seven Fleet Capital Management LP |
| 0.02% | 0.04% | #11 | $139,496 | 10,600 | $134,620 | 10,600 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | — | #23 | $99,476 | 7,559 | $0 | 0 | +7,559 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #24 | $9,093 | 691 | $16,510 | 1,300 | -609-46.85% | Reduce |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #21 | $4,737 | 360 | $4,572 | 360 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #25 | $3,000 | 218 | $4,000 | 268 | -50-18.66% | Reduce |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #20 | $1,237 | 94 | $1,270 | 100 | -6-6.00% | Reduce |
| Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #26 | $131 | 10 | $127 | 10 | 00.00% | Unchanged |
| TD Waterhouse Canada Inc. |
| <0.01% | <0.01% | #27 | $66 | 5 | $65 | 5 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #22 | $39 | 3 | $0 | 0 | +3 | New Buy |
