| Vivo Capital, LLC |
| 1.39% | 0.9% | #4 | $15.3M | 3.2M | $10.8M | 3.2M | 00.00% | Unchanged |
| Commodore Capital LP |
| 0.85% | 0.46% | #5 | $14.2M | 2.9M | $8.0M | 2.3M | +599,967+25.71% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $11.2M | 2.3M | $7.6M | 2.2M | +96,190+4.33% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #34 | $8.1M | 1.7M | $1.1M | 318,768 | +1.3M+422.48% | Add |
| Spruce Street Capital LP |
| 1.58% | 1.34% | #3 | $8.0M | 1.7M | $5.6M | 1.7M | 00.00% | Unchanged |
| Almitas Capital LLC |
| 1.66% | 1.14% | #2 | $7.1M | 1.5M | $5.1M | 1.5M | -10,000-0.68% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $6.0M | 1.2M | $3.5M | 1.0M | +227,627+22.51% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #16 | $4.8M | 1.0M | $3.4M | 1.0M | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #23 | $4.6M | 951,997 | $530,917 | 155,239 | +796,758+513.25% | Add |
| Boxer Capital Management, LLC |
| 0.27% | 0.34% | #9 | $3.6M | 749,035 | $2.6M | 749,035 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #31 | $3.4M | 697,806 | $980,838 | 286,547 | +411,259+143.52% | Add |
| SummitTX Capital, L.P. |
| 0.07% | — | #12 | $2.9M | 597,453 | $0 | 0 | +597,453 | New Buy |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #20 | $2.7M | 556,027 | $0 | 0 | +556,027 | New Buy |
| Stonepine Capital Management, LLC |
| 0.41% | 0.98% | #7 | $2.7M | 551,692 | $2.4M | 713,845 | -162,153-22.72% | Reduce |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #24 | $2.6M | 537,064 | $2.4M | 696,181 | -159,117-22.86% | Reduce |
| Sio Capital Management, LLC |
| 0.42% | 0.32% | #6 | $2.6M | 529,933 | $2.2M | 657,200 | -127,267-19.37% | Reduce |
| Ally Bridge Group (NY) LLC |
| 2.25% | 1.45% | #1 | $2.5M | 526,315 | $1.8M | 526,315 | 00.00% | Unchanged |
| Prosight Management, LP |
| 0.4% | 0.29% | #8 | $2.3M | 474,638 | $1.8M | 515,754 | -41,116-7.97% | Reduce |
| Woodline Partners LP |
| 0.01% | 0.01% | #15 | $2.2M | 459,805 | $3.4M | 993,671 | -533,866-53.73% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #42 | $1.5M | 311,602 | $393,991 | 115,202 | +196,400+170.48% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #33 | $1.0M | 214,921 | $147,730 | 43,196 | +171,725+397.55% | Add |
| Seven Fleet Capital Management LP |
| 0.17% | 0.22% | #10 | $1.0M | 208,946 | $682,977 | 199,701 | +9,245+4.63% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #29 | $953,093 | 196,920 | $470,961 | 137,708 | +59,212+43.00% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #46 | $869,235 | 179,594 | $0 | 0 | +179,594 | New Buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.05% | 0.06% | #13 | $810,438 | 167,446 | $1.0M | 298,166 | -130,720-43.84% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #41 | $705,686 | 145,803 | $1.3M | 393,702 | -247,899-62.97% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #22 | $627,748 | 129,700 | $679,896 | 198,800 | -69,100-34.76% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #47 | $425,596 | 87,933 | $0 | 0 | +87,933 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #37 | $368,058 | 76,045 | $0 | 0 | +76,045 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #40 | $358,576 | 74,086 | $209,961 | 61,392 | +12,694+20.68% | Add |
| Walleye Capital LLC |
| <0.01% | — | #21 | $349,153 | 72,139 | $0 | 0 | +72,139 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #39 | $327,552 | 67,676 | $0 | 0 | +67,676 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #43 | $310,825 | 64,220 | $0 | 0 | +64,220 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #18 | $289,916 | 59,900 | $204,858 | 59,900 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.01% | <0.01% | #14 | $284,631 | 58,808 | $47,405 | 13,861 | +44,947+324.27% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #56 | $238,995 | 49,379 | $242,278 | 190,770 | -141,391-74.12% | Reduce |
| CAPTRUST FINANCIAL ADVISORS |
| <0.01% | <0.01% | #27 | $194,399 | 40,165 | $136,800 | 40,000 | +165+0.41% | Add |
| Velan Capital Investment Management LP |
| 0.12% | — | #11 | $193,600 | 40,000 | $0 | 0 | +40,000 | New Buy |
| Nuveen, LLC |
| <0.01% | — | #44 | $171,012 | 35,333 | $0 | 0 | +35,333 | New Buy |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #48 | $125,056 | 25,838 | $0 | 0 | +25,838 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #35 | $117,810 | 24,342 | $0 | 0 | +24,342 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #53 | $108,363 | 22,389 | $0 | 0 | +22,389 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #57 | $106,586 | 22,022 | $0 | 0 | +22,022 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #38 | $77,019 | 15,913 | $0 | 0 | +15,913 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #59 | $66,981 | 13,839 | $0 | 0 | +13,839 | New Buy |
| LPL Financial LLC |
| <0.01% | — | #55 | $59,774 | 12,350 | $0 | 0 | +12,350 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #52 | $59,373 | 12,267 | $65,281 | 19,088 | -6,821-35.73% | Reduce |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #36 | $58,980 | 12,186 | $0 | 0 | +12,186 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | — | #62 | $55,184 | 10,971 | $0 | 0 | +10,971 | New Buy |
| Bronte Capital Management Pty Ltd. |
| 0.01% | — | #17 | $52,732 | 10,895 | $0 | 0 | +10,895 | New Buy |
