| MORGAN STANLEY |
| <0.01% | <0.01% | #28 | $28.5M | 11.7M | $49.8M | 11.8M | -75,116-0.64% | Reduce |
| Soleus Capital Management, L.P. |
| 0.85% | 0.97% | #1 | $24.6M | 10.1M | $23.9M | 10.1M | +55,000+0.55% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #56 | $17.6M | 7.2M | $11.6M | 4.9M | +2.3M+47.96% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #29 | $7.4M | 3.1M | $6.9M | 2.9M | +159,291+5.51% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $7.3M | 3.0M | $2.1M | 881,717 | +2.1M+241.58% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #72 | $7.1M | 2.9M | $6.9M | 2.9M | +5,103+0.18% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #22 | $7.0M | 2.9M | $5.4M | 2.3M | +590,339+25.69% | Add |
| Assenagon Asset Management S.A. |
| 0.01% | 0.01% | #16 | $4.8M | 2.0M | $4.7M | 2.0M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $4.7M | 1.9M | $4.2M | 1.8M | +151,590+8.50% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #30 | $4.1M | 1.7M | $4.0M | 1.7M | +505+0.03% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $3.9M | 1.6M | $3.4M | 1.4M | +158,637+10.95% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | 0.01% | #18 | $3.8M | 1.5M | $3.7M | 1.6M | -31,559-2.00% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #86 | $3.7M | 1.5M | $3.6M | 1.5M | -5,153-0.34% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #21 | $2.5M | 1.0M | $2.5M | 1.1M | -51,425-4.81% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #53 | $2.2M | 905,024 | $2.1M | 879,832 | +25,192+2.86% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $2.2M | 887,399 | $1.2M | 520,350 | +367,049+70.54% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #59 | $2.1M | 867,929 | $1.3M | 544,235 | +323,694+59.48% | Add |
| SG Americas Securities, LLC |
| <0.01% | <0.01% | #36 | $1.9M | 772,737 | $1.9M | 790,766 | -18,029-2.28% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.01% | — | #15 | $1.7M | 692,197 | $0 | 0 | +692,197 | New Buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| <0.01% | — | #24 | $1.5M | 628,700 | $0 | 0 | +628,700 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #68 | $1.4M | 584,577 | $1.3M | 554,428 | +30,149+5.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #88 | $1.4M | 563,048 | $1.3M | 548,262 | +14,786+2.70% | Add |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.17% | 0.21% | #3 | $1.3M | 550,000 | $1.3M | 550,000 | 00.00% | Unchanged |
| NORGES BANK |
| <0.01% | <0.01% | #75 | $1.3M | 530,900 | $2.1M | 482,200 | +48,700+10.10% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #55 | $1.2M | 495,363 | $1.2M | 498,452 | -3,089-0.62% | Reduce |
| FLAX POND CAPITAL, LLC |
| 0.76% | 0.8% | #2 | $995,616 | 420,091 | $995,616 | 420,091 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #85 | $871,661 | 358,708 | $491,841 | 207,528 | +151,180+72.85% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #76 | $776,732 | 319,643 | $695,952 | 293,651 | +25,992+8.85% | Add |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #35 | $755,154 | 310,763 | $0 | 0 | +310,763 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #37 | $613,881 | 252,626 | $737,501 | 311,182 | -58,556-18.82% | Reduce |
| ExodusPoint Capital Management, LP |
| <0.01% | — | #20 | $556,067 | 228,834 | $0 | 0 | +228,834 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #112 | $523,944 | 215,615 | $890,682 | 375,815 | -160,200-42.63% | Reduce |
| Hennion & Walsh Asset Management, Inc. |
| 0.01% | 0.02% | #11 | $507,863 | 208,997 | $499,658 | 210,826 | -1,829-0.87% | Reduce |
| VOYA INVESTMENT MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $498,667 | 205,213 | $451,469 | 190,493 | +14,720+7.73% | Add |
| Nuveen, LLC |
| <0.01% | <0.01% | #84 | $469,488 | 193,205 | $447,326 | 188,745 | +4,460+2.36% | Add |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #79 | $454,354 | 186,977 | $330,951 | 139,642 | +47,335+33.90% | Add |
| XTX Topco Ltd |
| 0.01% | — | #17 | $446,537 | 183,760 | $0 | 0 | +183,760 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #64 | $419,586 | 172,669 | $77,648 | 32,763 | +139,906+427.02% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #105 | $410,437 | 168,904 | $385,686 | 162,737 | +6,167+3.79% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #94 | $394,780 | 162,461 | $85,444 | 36,052 | +126,409+350.63% | Add |
| Wealth Dimensions Group, Ltd. |
| 0.07% | 0.19% | #6 | $369,968 | 152,250 | $966,877 | 407,965 | -255,715-62.68% | Reduce |
| Mariner, LLC |
| <0.01% | <0.01% | #45 | $358,977 | 147,731 | $59,232 | 24,986 | +122,745+491.26% | Add |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #71 | $351,769 | 144,761 | $399,042 | 168,372 | -23,611-14.02% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #83 | $351,518 | 148,320 | $643,822 | 124,290 | +24,030+19.33% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #74 | $323,561 | 139,166 | $122,113 | 51,963 | +87,203+167.82% | Add |
| Cerity Partners LLC |
| <0.01% | <0.01% | #46 | $310,018 | 127,579 | $149,095 | 62,909 | +64,670+102.80% | Add |
| AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #101 | $239,445 | 98,537 | $85,109 | 35,911 | +62,626+174.39% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #70 | $208,147 | 85,660 | $189,624 | 80,015 | +5,645+7.05% | Add |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #44 | $205,943 | 84,750 | $1.1M | 456,367 | -371,617-81.43% | Reduce |
| Creative Planning |
| <0.01% | <0.01% | #80 | $205,160 | 84,428 | $52,981 | 22,355 | +62,073+277.67% | Add |
