| EcoR1 Capital, LLC |
| 0.87% | 0.02% | #1 | $17.8M | 1.6M | $471,075 | 99,593 | +1.5M+1,458.34% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #4 | $9.8M | 850,000 | $3.3M | 700,000 | +150,000+21.43% | Add |
| Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #5 | $7.9M | 687,718 | $918,869 | 194,264 | +493,454+254.01% | Add |
| Redmile Group, LLC |
| 0.34% | 0.14% | #2 | $5.1M | 441,701 | $2.1M | 441,701 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #15 | $2.8M | 247,047 | $1.0M | 217,862 | +29,185+13.40% | Add |
| MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #7 | $2.7M | 233,249 | $1.5M | 313,620 | -80,371-25.63% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #22 | $969,544 | 84,455 | $373,773 | 79,022 | +5,433+6.88% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $862,924 | 75,128 | $313,045 | 66,146 | +8,982+13.58% | Add |
| STALEY CAPITAL ADVISERS INC |
| 0.02% | 0.01% | #3 | $574,000 | 50,000 | $236,500 | 50,000 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #14 | $494,053 | 43,036 | $159,027 | 33,621 | +9,415+28.00% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #9 | $445,941 | 38,845 | $617,000 | 130,910 | -92,065-70.33% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #19 | $348,360 | 30,345 | $160,206 | 33,870 | -3,525-10.41% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #24 | $303,680 | 26,453 | $125,123 | 26,453 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #21 | $190,465 | 16,591 | $58,368 | 12,340 | +4,251+34.45% | Add |
| FMR LLC |
| <0.01% | <0.01% | #26 | $186,412 | 16,238 | $76,806 | 16,238 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #8 | $175,678 | 15,303 | $0 | 0 | +15,303 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #6 | $160,720 | 14,000 | $154,628 | 32,691 | -18,691-57.17% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #16 | $145,566 | 12,680 | $225,569 | 47,689 | -35,009-73.41% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #23 | $116,625 | 10,159 | $0 | 0 | +10,159 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #29 | $105,368 | 9,178 | $514,991 | 35,938 | -26,760-74.46% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #25 | $55,000 | 4,743 | $20,000 | 4,319 | +424+9.82% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #28 | $45,679 | 3,979 | $236,831 | 50,070 | -46,091-92.05% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #27 | $16,715 | 1,456 | $6,887 | 1,456 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #11 | $16,118 | 1,404 | $7,445 | 1,574 | -170-10.80% | Reduce |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #30 | $8,440 | 803 | $3,227 | 703 | +100+14.22% | Add |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #10 | $3,570 | 311 | $0 | 0 | +311 | New Buy |
| BARCLAYS PLC |
| <0.01% | — | #31 | $3,490 | 304 | $0 | 0 | +304 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #32 | $2,881 | 251 | $1,187 | 251 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #37 | $2,413 | 216 | $933 | 216 | 00.00% | Unchanged |
| Raiffeisen Bank International AG |
| <0.01% | <0.01% | #20 | $2,296 | 200 | $946 | 200 | 00.00% | Unchanged |
| Banque Transatlantique SA |
| <0.01% | <0.01% | #18 | $1,936 | 176 | $906 | 176 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #33 | $1,114 | 97 | $5 | 1 | +96+9,600.00% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #34 | $528 | 46 | $274 | 58 | -12-20.69% | Reduce |
| PlanVest Financial, Inc |
| <0.01% | <0.01% | #13 | $321 | 28 | $132 | 28 | 00.00% | Unchanged |
| KERR FINANCIAL PLANNING Corp |
| <0.01% | <0.01% | #12 | $276 | 24 | $116 | 24 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #36 | $114 | 10 | $47 | 10 | 00.00% | Unchanged |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #35 | $92 | 8 | $38 | 8 | 00.00% | Unchanged |
