| Squadron Capital Management LLC |
| 6.21% | 3.46% | #2 | $20.0M | 4.1M | $9.4M | 4.0M | +95,000+2.36% | Add |
| 5AM Venture Management, LLC |
| 6.65% | 2.56% | #1 | $19.1M | 3.9M | $9.2M | 3.9M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #67 | $18.2M | 3.8M | $3.0M | 1.3M | +2.5M+195.59% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #29 | $14.7M | 3.0M | $6.9M | 3.0M | +68,410+2.31% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $13.8M | 2.8M | $5.4M | 2.3M | +524,962+22.72% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.02% | 0.01% | #26 | $13.0M | 2.7M | $6.7M | 2.8M | -166,352-5.84% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #45 | $11.3M | 2.3M | $4.1M | 1.8M | +581,520+33.11% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #28 | $7.8M | 1.6M | $4.5M | 1.9M | -329,067-16.98% | Reduce |
| Opaleye Management Inc. |
| 0.62% | 0.44% | #7 | $6.9M | 1.4M | $3.3M | 1.4M | 00.00% | Unchanged |
| ORBIMED ADVISORS LLC |
| 0.13% | — | #13 | $6.7M | 1.4M | $0 | 0 | +1.4M | New Buy |
| Decheng Capital LLC |
| 0.88% | 0.47% | #5 | $6.4M | 1.3M | $3.1M | 1.3M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #64 | $6.2M | 1.3M | $1.5M | 621,036 | +663,081+106.77% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #63 | $5.4M | 1.1M | $2.6M | 1.1M | -17,644-1.56% | Reduce |
| Ishara Investments LP |
| 3.59% | 2.72% | #3 | $5.0M | 1.0M | $2.9M | 1.2M | -205,000-16.67% | Reduce |
| PRIMECAP MANAGEMENT CO/CA/ |
| <0.01% | <0.01% | #36 | $4.6M | 957,420 | $2.2M | 957,420 | 00.00% | Unchanged |
| Soleus Capital Management, L.P. |
| 0.16% | — | #11 | $4.6M | 950,000 | $0 | 0 | +950,000 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #81 | $4.3M | 887,416 | $584,275 | 249,690 | +637,726+255.41% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $3.9M | 808,548 | $843,804 | 360,600 | +447,948+124.22% | Add |
| PFIZER INC |
| 2.26% | 0.84% | #4 | $3.9M | 953,834 | $2.0M | 953,834 | 00.00% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | <0.01% | #32 | $3.7M | 758,033 | $1.9M | 792,001 | -33,968-4.29% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $3.2M | 664,281 | $3.0M | 1.3M | -625,541-48.50% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.02% | #12 | $3.2M | 652,750 | $338,448 | 144,636 | +508,114+351.31% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #40 | $2.9M | 591,473 | $918,785 | 392,643 | +198,830+50.64% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #37 | $2.8M | 574,806 | $1.5M | 637,116 | -62,310-9.78% | Reduce |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $2.7M | 546,566 | $3.5M | 1.5M | -937,532-63.17% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $2.6M | 542,852 | $634,296 | 272,034 | +270,818+99.55% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #82 | $2.3M | 471,250 | $2.1M | 1.4M | -936,579-66.53% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #70 | $1.9M | 388,299 | $276,555 | 118,186 | +270,113+228.55% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.11% | 0.09% | #16 | $1.8M | 374,260 | $1.5M | 620,407 | -246,147-39.68% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $1.8M | 372,564 | $1.1M | 462,678 | -90,114-19.48% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #62 | $1.6M | 336,940 | $712,462 | 304,471 | +32,469+10.66% | Add |
| FMR LLC |
| <0.01% | <0.01% | #94 | $1.5M | 310,264 | $664,366 | 283,917 | +26,347+9.28% | Add |
| Seven Fleet Capital Management LP |
| 0.24% | 0.08% | #9 | $1.5M | 317,600 | $257,400 | 110,000 | +207,600+188.73% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #75 | $1.4M | 297,378 | $364,348 | 155,704 | +141,674+90.99% | Add |
| XTX Topco Ltd |
| 0.02% | 0.01% | #24 | $1.4M | 289,693 | $754,666 | 322,507 | -32,814-10.17% | Reduce |
| Creative Planning |
| <0.01% | <0.01% | #50 | $1.4M | 285,000 | $666,900 | 285,000 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $1.3M | 269,013 | $1.4M | 616,557 | -347,544-56.37% | Reduce |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #48 | $1.2M | 256,079 | $448,229 | 191,551 | +64,528+33.69% | Add |
| Peapod Lane Capital LLC |
| 0.66% | 0.68% | #6 | $983,890 | 202,864 | $834,581 | 366,868 | -164,004-44.70% | Reduce |
| CDC Financial, Inc. |
| 0.36% | 0.42% | #8 | $862,146 | 177,762 | $664,003 | 283,762 | -106,000-37.36% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #84 | $833,768 | 171,911 | $119,544 | 51,087 | +120,824+236.51% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #95 | $784,037 | 161,657 | $294,295 | 125,767 | +35,890+28.54% | Add |
| Stonepine Capital Management, LLC |
| 0.12% | 0.25% | #14 | $783,678 | 161,583 | $629,694 | 269,100 | -107,517-39.95% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #78 | $770,452 | 158,856 | $1.4M | 591,217 | -432,361-73.13% | Reduce |
| Informed Momentum Co LLC |
| 0.05% | — | #19 | $615,286 | 126,863 | $0 | 0 | +126,863 | New Buy |
| Quarry LP |
| 0.05% | 0.06% | #21 | $606,803 | 125,114 | $351,000 | 150,000 | -24,886-16.59% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #87 | $592,030 | 122,068 | $0 | 0 | +122,068 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #98 | $550,936 | 113,595 | $1.1M | 490,339 | -376,744-76.83% | Reduce |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #31 | $543,792 | 112,122 | $0 | 0 | +112,122 | New Buy |
| BARR E S & CO |
| 0.03% | 0.02% | #23 | $533,500 | 110,000 | $257,400 | 110,000 | 00.00% | Unchanged |
