| FMR LLC |
| 0.21% | 0.19% | #71 | $4.85B | 5.2M | $3.64B | 5.0M | +240,418+4.82% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.25% | 0.28% | #61 | $2.48B | 2.7M | $2.46B | 3.4M | -696,908-20.65% | Reduce |
| Jupiter Topco LLC |
| 0.94% | — | #25 | $2.30B | 2.5M | $0 | 0 | +2.5M | New Buy |
| Capital World Investors |
| 0.24% | 0.22% | #64 | $2.04B | 2.2M | $1.65B | 2.3M | -56,446-2.50% | Reduce |
| Artisan Partners Limited Partnership |
| 2.22% | 1.72% | #13 | $1.40B | 1.5M | $1.07B | 1.5M | +40,796+2.78% | Add |
| Avoro Capital Advisors LLC |
| 8.33% | 7.18% | #3 | $927.8M | 1.0M | $730.3M | 1.0M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.15% | 0.14% | #88 | $863.3M | 930,548 | $745.9M | 1.0M | -90,909-8.90% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #266 | $721.1M | 777,237 | $590.3M | 808,337 | -31,100-3.85% | Reduce |
| RTW INVESTMENTS, LP |
| 5.62% | 5.16% | #5 | $658.2M | 709,446 | $518.1M | 709,446 | 00.00% | Unchanged |
| MORGAN STANLEY |
| 0.03% | 0.02% | #181 | $596.7M | 643,123 | $320.9M | 435,106 | +208,017+47.81% | Add |
| Invesco Ltd. |
| 0.03% | 0.06% | #180 | $411.9M | 443,990 | $434.3M | 594,697 | -150,707-25.34% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.02% | 0.02% | #202 | $371.3M | 400,234 | $292.2M | 400,117 | +117+0.03% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.1% | 0.11% | #114 | $288.9M | 395,661 | $355.1M | 422,304 | -26,643-6.31% | Reduce |
| Bellevue Group AG |
| 5.88% | 5.44% | #4 | $279.3M | 301,000 | $228.6M | 313,000 | -12,000-3.83% | Reduce |
| SANDS CAPITAL MANAGEMENT, LLC |
| 1.03% | 0.97% | #23 | $277.0M | 298,599 | $248.5M | 340,285 | -41,686-12.25% | Reduce |
| CITADEL ADVISORS LLC |
| 0.03% | 0.03% | #192 | $253.6M | 273,316 | $211.9M | 290,226 | -16,910-5.83% | Reduce |
| BESSEMER GROUP INC |
| 0.34% | 0.07% | #47 | $248.4M | 267,779 | $46.9M | 64,251 | +203,528+316.77% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.74% | 0.64% | #32 | $245.5M | 264,617 | $194.4M | 266,067 | -1,450-0.54% | Reduce |
| SEI INVESTMENTS CO |
| 0.21% | 0.19% | #73 | $236.7M | 255,073 | $209.6M | 286,966 | -31,893-11.11% | Reduce |
| Clearbridge Investments, LLC |
| 0.19% | 0.15% | #77 | $235.4M | 253,776 | $168.9M | 231,356 | +22,420+9.69% | Add |
| JENNISON ASSOCIATES LLC |
| 0.13% | 0.12% | #95 | $209.9M | 226,200 | $173.4M | 237,468 | -11,268-4.75% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.04% | 0.04% | #166 | $208.7M | 224,930 | $170.5M | 233,493 | -8,563-3.67% | Reduce |
| Pictet Asset Management Holding SA |
| 0.18% | 0.11% | #81 | $183.8M | 198,282 | $108.0M | 148,306 | +49,976+33.70% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.13% | 0.06% | #96 | $172.8M | 186,238 | $79.7M | 109,121 | +77,117+70.67% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.03% | 0.04% | #177 | $168.4M | 181,464 | $157.7M | 215,910 | -34,446-15.95% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #239 | $165.0M | 177,846 | $169.4M | 231,985 | -54,139-23.34% | Reduce |
| Legal & General Group Plc |
| 0.03% | 0.03% | #175 | $164.4M | 177,164 | $110.2M | 150,850 | +26,314+17.44% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.07% | 0.07% | #139 | $160.7M | 173,193 | $126.8M | 173,700 | -507-0.29% | Reduce |
| Allspring Global Investments Holdings, LLC |
| 0.24% | 0.22% | #65 | $155.4M | 170,829 | $130.3M | 175,311 | -4,482-2.56% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.07% | 0.06% | #140 | $146.5M | 157,958 | $129.9M | 177,836 | -19,878-11.18% | Reduce |
| 1832 Asset Management L.P. |
| 0.07% | 0.06% | #137 | $146.5M | 157,940 | $61.5M | 84,200 | +73,740+87.58% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.02% | #262 | $145.5M | 156,774 | $174.7M | 239,292 | -82,518-34.48% | Reduce |
| DEUTSCHE BANK AG\ |
| 0.04% | 0.03% | #171 | $127.4M | 137,335 | $101.8M | 139,381 | -2,046-1.47% | Reduce |
| BAMCO INC /NY/ |
| 0.19% | 0.31% | #78 | $126.8M | 136,654 | $101.2M | 138,648 | -1,994-1.44% | Reduce |
| BARCLAYS PLC |
| 0.02% | <0.01% | #203 | $124.7M | 134,427 | $4.0M | 5,500 | +128,927+2,344.13% | Add |
| LAZARD ASSET MANAGEMENT LLC |
| 0.17% | 0.16% | #82 | $122.5M | 131,996 | $97.4M | 133,347 | -1,351-1.01% | Reduce |
| Checkpoint Capital L.P. |
| 31.25% | 40.1% | #1 | $121.8M | 131,283 | $111.7M | 153,000 | -21,717-14.19% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.56% | 1.52% | #18 | $116.6M | 125,668 | $91.7M | 125,657 | +11+0.01% | Add |
| AGF MANAGEMENT LTD |
| 0.45% | 0.41% | #40 | $116.4M | 125,481 | $91.3M | 125,069 | +412+0.33% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.11% | — | #104 | $113.0M | 121,786 | $0 | 0 | +121,786 | New Buy |
| LORD, ABBETT & CO. LLC |
| 0.29% | 0.36% | #52 | $100.4M | 108,253 | $111.1M | 152,083 | -43,830-28.82% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.06% | 0.06% | #153 | $94.1M | 101,440 | $78.3M | 107,195 | -5,755-5.37% | Reduce |
| PGGM Investments |
| 2.19% | 0.92% | #14 | $89.5M | 96,511 | $52.2M | 71,514 | +24,997+34.95% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #190 | $87.6M | 94,401 | $52.8M | 72,365 | +22,036+30.45% | Add |
| ORBIMED ADVISORS LLC |
| 1.63% | 1.98% | #17 | $86.2M | 92,880 | $100.0M | 136,900 | -44,020-32.15% | Reduce |
| Fiera Capital Corp |
| 0.3% | 0.54% | #50 | $83.9M | 90,423 | $158.6M | 217,198 | -126,775-58.37% | Reduce |
| Capital Research Global Investors |
| 0.01% | — | #261 | $82.1M | 88,511 | $0 | 0 | +88,511 | New Buy |
| FEDERATED HERMES, INC. |
| 0.12% | 0.11% | #101 | $81.0M | 87,288 | $69.6M | 95,253 | -7,965-8.36% | Reduce |
| PINEBRIDGE INVESTMENTS LLC |
| 0.67% | 0.64% | #33 | $80.8M | 87,050 | $75.8M | 103,812 | -16,762-16.15% | Reduce |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.2% | 0.17% | #74 | $78.2M | 84,300 | $53.5M | 73,300 | +11,000+15.01% | Add |
