| Jupiter Topco LLC |
| 0.43% | — | #39 | $1.05B | 14.1M | $0 | 0 | +14.1M | New Buy |
| Kohlberg Kravis Roberts & Co. L.P. |
| 17.3% | 18.42% | #2 | $987.7M | 13.3M | $984.8M | 13.3M | 00.00% | Unchanged |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 3.69% | 3.96% | #6 | $800.1M | 10.7M | $695.5M | 9.4M | +1.4M+14.71% | Add |
| BlackRock, Inc. |
| 0.01% | 0.02% | #213 | $766.2M | 10.3M | $1.06B | 14.2M | -3.9M-27.59% | Reduce |
| VIKING GLOBAL INVESTORS LP |
| 2.11% | 2.46% | #14 | $741.0M | 9.9M | $879.4M | 11.8M | -1.9M-15.99% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #199 | $588.3M | 7.9M | $576.2M | 7.8M | +139,478+1.80% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.03% | #157 | $570.3M | 7.7M | $600.1M | 8.1M | -423,851-5.25% | Reduce |
| JANE STREET GROUP, LLC |
| 0.04% | 0.05% | #141 | $455.3M | 6.1M | $366.5M | 4.9M | +1.2M+23.87% | Add |
| UBS Group AG |
| 0.05% | 0.07% | #123 | $420.8M | 5.6M | $437.4M | 5.9M | -240,969-4.09% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.03% | #115 | $395.4M | 5.3M | $184.5M | 2.5M | +2.8M+113.73% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.26% | 0.19% | #53 | $353.4M | 4.7M | $231.7M | 3.1M | +1.6M+52.06% | Add |
| Aisling Capital Management LP |
| 72.48% | 79.35% | #1 | $341.8M | 4.6M | $378.0M | 5.1M | -500,000-9.82% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #230 | $330.4M | 4.4M | $366.4M | 4.9M | -498,388-10.10% | Reduce |
| CITADEL ADVISORS LLC |
| 0.04% | 0.04% | #143 | $322.3M | 4.3M | $251.8M | 3.4M | +936,688+27.63% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.03% | #160 | $317.2M | 4.3M | $267.9M | 3.6M | +651,681+18.07% | Add |
| Invesco Ltd. |
| 0.02% | 0.05% | #166 | $275.6M | 3.7M | $341.1M | 4.6M | -891,880-19.42% | Reduce |
| D. E. Shaw & Co., Inc. |
| 0.13% | 0.11% | #80 | $272.9M | 3.7M | $189.0M | 2.5M | +1.1M+43.94% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.02% | #193 | $254.7M | 3.4M | $371.9M | 4.9M | -1.5M-30.49% | Reduce |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #235 | $173.2M | 2.4M | $91.0M | 1.3M | +1.1M+82.74% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.24% | 0.07% | #55 | $167.7M | 2.3M | $44.5M | 599,000 | +1.7M+275.96% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.04% | #147 | $160.9M | 2.2M | $181.1M | 2.4M | -278,752-11.43% | Reduce |
| Polar Capital Holdings Plc |
| 0.36% | 0.66% | #42 | $153.7M | 2.1M | $187.1M | 2.5M | -455,697-18.09% | Reduce |
| FMR LLC |
| 0.01% | 0.01% | #261 | $153.5M | 2.1M | $174.0M | 2.3M | -282,447-12.05% | Reduce |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.11% | 0.13% | #88 | $145.7M | 2.0M | $146.8M | 2.0M | -21,347-1.08% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #204 | $139.1M | 1.9M | $145.4M | 2.0M | -89,559-4.57% | Reduce |
| SC US (TTGP), LTD. |
| 0.43% | 1.49% | #38 | $138.6M | 1.9M | $138.2M | 1.9M | 00.00% | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.03% | #197 | $128.6M | 1.7M | $282.3M | 3.8M | -2.1M-54.59% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.02% | #179 | $127.3M | 1.7M | $146.7M | 2.0M | -266,677-13.50% | Reduce |
| NORGES BANK |
| 0.01% | 0.01% | #198 | $126.2M | 1.7M | $43.0M | 1.2M | +448,818+36.05% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #260 | $126.1M | 1.7M | $54.8M | 1.1M | +638,787+60.56% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | 0.02% | #164 | $115.6M | 1.6M | $92.7M | 1.2M | +303,142+24.28% | Add |
| Frazier Life Sciences Management, L.P. |
| 2.51% | 6.59% | #10 | $115.3M | 1.5M | $256.1M | 3.4M | -1.9M-55.10% | Reduce |
| Point72 Asset Management, L.P. |
| 0.13% | <0.01% | #81 | $114.2M | 1.5M | $3.5M | 47,200 | +1.5M+3,147.42% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.04% | 0.05% | #145 | $107.9M | 1.5M | $146.0M | 1.9M | -455,403-23.86% | Reduce |
| Pictet Asset Management Holding SA |
| 0.1% | 0.11% | #94 | $107.4M | 1.4M | $101.5M | 1.4M | +66,942+4.85% | Add |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.95% | 0.73% | #22 | $102.3M | 1.4M | $71.1M | 957,989 | +415,068+43.33% | Add |
| Laurion Capital Management LP |
| 2.58% | 4.09% | #9 | $100.7M | 1.4M | $93.8M | 1.3M | +89,583+7.09% | Add |
| Hood River Capital Management LLC |
| 0.73% | 0.94% | #28 | $100.4M | 1.3M | $93.9M | 1.3M | +82,455+6.52% | Add |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #271 | $92.0M | 1.2M | $95.5M | 1.3M | -50,368-3.92% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.11% | 0.03% | #86 | $91.6M | 1.2M | $26.0M | 350,096 | +879,956+251.35% | Add |
| Squarepoint Ops LLC |
| 0.1% | 0.05% | #96 | $88.8M | 1.2M | $41.3M | 556,324 | +635,408+114.22% | Add |
| Bellevue Group AG |
| 1.86% | 0.04% | #16 | $88.6M | 1.2M | $1.9M | 25,377 | +1.2M+4,587.34% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.04% | 0.05% | #137 | $86.1M | 1.2M | $97.1M | 1.3M | -151,734-11.61% | Reduce |
| GW&K Investment Management, LLC |
| 0.65% | 0.63% | #31 | $83.8M | 1.1M | $71.5M | 962,643 | +162,488+16.88% | Add |
| CITIGROUP INC |
| 0.03% | 0.03% | #153 | $83.4M | 1.1M | $72.2M | 972,483 | +147,618+15.18% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #177 | $83.2M | 1.1M | $87.3M | 1.2M | -58,146-4.95% | Reduce |
| HRT FINANCIAL LP |
| 0.15% | 0.01% | #73 | $81.1M | 1.1M | $5.3M | 71,865 | +1.0M+1,415.86% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.04% | 0.05% | #142 | $76.3M | 1.0M | $98.8M | 1.3M | -305,992-23.00% | Reduce |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.04% | 0.03% | #133 | $75.7M | 1.0M | $42.3M | 569,180 | +446,800+78.50% | Add |
| FIL Ltd |
| 0.05% | <0.01% | #125 | $74.6M | 1.0M | $6,535 | 88 | +1.0M+1,138,831.82% | Add |
