| FMR LLC |
| 0.08% | 0.1% | #106 | $1.95B | 24.6M | $1.84B | 24.6M | +75,319+0.31% | Add |
| Capital World Investors |
| 0.2% | 0.22% | #68 | $1.72B | 21.7M | $1.59B | 21.2M | +482,857+2.28% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #222 | $848.8M | 10.7M | $784.1M | 10.4M | +262,184+2.51% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.03% | #151 | $623.2M | 7.9M | $586.4M | 7.8M | +50,627+0.65% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.1% | 0.09% | #98 | $606.7M | 7.7M | $480.0M | 6.4M | +1.3M+19.71% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #224 | $571.8M | 7.2M | $534.5M | 7.1M | +93,167+1.31% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.36% | 0.35% | #44 | $495.7M | 6.3M | $439.8M | 5.9M | +394,713+6.74% | Add |
| ROYAL BANK OF CANADA |
| 0.07% | 0.05% | #116 | $490.2M | 6.2M | $285.5M | 3.8M | +2.4M+62.62% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #243 | $343.7M | 4.3M | $300.0M | 4.0M | +339,284+8.49% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.21% | 0.32% | #67 | $313.9M | 4.0M | $462.5M | 6.2M | -2.2M-35.71% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.02% | #190 | $294.8M | 3.6M | $305.2M | 4.0M | -400,308-10.05% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.03% | #160 | $252.5M | 3.2M | $227.2M | 3.0M | +159,249+5.26% | Add |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #227 | $216.2M | 2.7M | $171.4M | 2.4M | +308,150+13.04% | Add |
| Artisan Partners Limited Partnership |
| 0.33% | 0.25% | #48 | $209.3M | 2.6M | $154.6M | 2.1M | +581,716+28.26% | Add |
| Tweedy, Browne Co LLC |
| 13.7% | 13.84% | #1 | $180.8M | 2.3M | $170.9M | 2.3M | +4,686+0.21% | Add |
| Deep Track Capital, LP |
| 2.54% | 2.39% | #13 | $174.4M | 2.2M | $146.4M | 2.0M | +250,000+12.82% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #218 | $168.6M | 2.1M | $91.8M | 1.2M | +903,880+73.94% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #204 | $167.3M | 2.1M | $127.6M | 1.7M | +410,098+24.13% | Add |
| BAKER BROS. ADVISORS LP |
| 0.81% | 0.88% | #23 | $162.4M | 2.0M | $153.8M | 2.0M | 00.00% | Unchanged |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.64% | 1.75% | #15 | $157.0M | 2.0M | $148.7M | 2.0M | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| 0.07% | 0.06% | #118 | $154.4M | 1.9M | $124.9M | 1.7M | +283,273+17.03% | Add |
| BARCLAYS PLC |
| 0.02% | 0.01% | #161 | $131.1M | 1.7M | $25.5M | 339,874 | +1.3M+386.40% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.03% | #155 | $128.7M | 1.6M | $118.3M | 1.6M | +48,354+3.07% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.02% | #185 | $127.3M | 1.6M | $118.9M | 1.6M | +21,788+1.38% | Add |
| JANE STREET GROUP, LLC |
| 0.01% | 0.01% | #239 | $127.1M | 1.6M | $57.1M | 760,318 | +842,029+110.75% | Add |
| Pictet Asset Management Holding SA |
| 0.12% | 0.11% | #88 | $127.0M | 1.6M | $107.1M | 1.4M | +162,003+11.29% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.02% | #170 | $115.3M | 1.5M | $110.8M | 1.5M | -20,960-1.42% | Reduce |
| Polar Capital Holdings Plc |
| 0.27% | 0.22% | #55 | $115.3M | 1.5M | $62.3M | 829,511 | +624,510+75.29% | Add |
| Alyeska Investment Group, L.P. |
| 0.29% | 0.1% | #53 | $112.4M | 1.4M | $35.5M | 473,150 | +944,766+199.68% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.15% | 0.1% | #76 | $103.1M | 1.3M | $59.0M | 785,281 | +515,111+65.60% | Add |
| MORGAN STANLEY |
| 0.01% | <0.01% | #302 | $101.6M | 1.3M | $77.2M | 1.2M | +101,128+8.57% | Add |
| Invesco Ltd. |
| 0.01% | 0.01% | #280 | $88.9M | 1.1M | $95.9M | 1.3M | -156,651-12.26% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.02% | #177 | $84.1M | 1.1M | $76.9M | 1.0M | +36,468+3.56% | Add |
| Caption Management, LLC |
| 0.36% | 0.01% | #43 | $77.5M | 977,659 | $1.2M | 15,591 | +962,068+6,170.66% | Add |
| Bellevue Group AG |
| 1.62% | 3.25% | #17 | $77.1M | 972,258 | $136.6M | 1.8M | -846,407-46.54% | Reduce |
| GROUPAMA ASSET MANAGMENT |
| 0.95% | 0.9% | #21 | $75.2M | 937,083 | $61.9M | 824,540 | +112,543+13.65% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #260 | $72.4M | 913,610 | $65.2M | 868,179 | +45,431+5.23% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.02% | #270 | $67.8M | 855,284 | $98.1M | 1.3M | -450,850-34.52% | Reduce |
| Capital International Investors |
| 0.01% | — | #213 | $65.3M | 823,764 | $0 | 0 | +823,764 | New Buy |
| Davern Capital Partners, LP |
| 10.8% | 7.97% | #2 | $63.3M | 798,709 | $29.1M | 386,903 | +411,806+106.44% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #318 | $62.7M | 790,990 | $63.1M | 840,598 | -49,608-5.90% | Reduce |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.1% | 3.74% | #19 | $62.4M | 787,263 | $139.2M | 1.9M | -1.1M-57.54% | Reduce |
| GW&K Investment Management, LLC |
| 0.46% | 0.52% | #38 | $59.2M | 746,966 | $58.5M | 779,349 | -32,383-4.16% | Reduce |
| BNP Paribas Asset Management Holding S.A. |
| 0.06% | — | #121 | $58.2M | 734,219 | $0 | 0 | +734,219 | New Buy |
| Nuveen, LLC |
| 0.01% | 0.01% | #211 | $57.6M | 726,282 | $48.7M | 648,496 | +77,786+11.99% | Add |
| Ikarian Capital, LLC |
| 5.89% | 1.46% | #4 | $55.5M | 700,000 | $18.0M | 239,138 | +460,862+192.72% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.1% | 0.15% | #99 | $54.3M | 684,236 | $65.6M | 874,089 | -189,853-21.72% | Reduce |
| Eversept Partners, LP |
| 2.73% | 2.5% | #11 | $52.7M | 664,684 | $47.5M | 632,100 | +32,584+5.15% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.22% | 0.2% | #60 | $52.0M | 655,454 | $50.5M | 672,858 | -17,404-2.59% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.02% | 0.02% | #186 | $51.7M | 651,816 | $50.0M | 666,116 | -14,300-2.15% | Reduce |
