| JOHNSON & JOHNSON |
| 2.59% | 5.84% | #1 | $20.7M | 4.0M | $38.1M | 4.0M | 00.00% | Unchanged |
| NEA Management Company, LLC |
| 0.63% | 1.09% | #3 | $10.0M | 2.0M | $19.2M | 2.0M | -71,643-3.54% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #42 | $6.4M | 1.2M | $9.7M | 1.0M | +218,900+21.32% | Add |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #19 | $6.3M | 1.2M | $6.7M | 706,928 | +526,284+74.45% | Add |
| GSK plc |
| 0.86% | 1.59% | #2 | $5.2M | 1.0M | $9.5M | 1.0M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $4.7M | 910,576 | $8.6M | 911,310 | -734-0.08% | Reduce |
| SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.03% | 0.04% | #6 | $4.5M | 878,109 | $5.4M | 572,021 | +306,088+53.51% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #39 | $2.3M | 440,786 | $4.0M | 427,072 | +13,714+3.21% | Add |
| PFM Health Sciences, LP |
| 0.16% | — | #4 | $1.9M | 369,572 | $0 | 0 | +369,572 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #49 | $1.9M | 366,352 | $3.3M | 350,548 | +15,804+4.51% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $1.2M | 230,000 | $182,578 | 19,300 | +210,700+1,091.71% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #35 | $1.2M | 224,233 | $982,043 | 103,810 | +120,423+116.00% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #16 | $1.1M | 205,684 | $1.9M | 197,340 | +8,344+4.23% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #46 | $768,476 | 149,509 | $1.9M | 201,011 | -51,502-25.62% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $745,182 | 144,977 | $3.5M | 431,551 | -286,574-66.41% | Reduce |
| Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #13 | $680,536 | 132,400 | $453,134 | 47,900 | +84,500+176.41% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $680,526 | 132,398 | $1.1M | 114,167 | +18,231+15.97% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $662,829 | 128,955 | $1.2M | 127,761 | +1,194+0.93% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #40 | $659,866 | 127,971 | $497,302 | 52,641 | +75,330+143.10% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $641,302 | 124,767 | $1.4M | 150,123 | -25,356-16.89% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $544,403 | 105,915 | $897,272 | 94,849 | +11,066+11.67% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $542,856 | 105,614 | $850,491 | 89,904 | +15,710+17.47% | Add |
| Cresset Asset Management, LLC |
| <0.01% | <0.01% | #14 | $533,784 | 103,849 | $1.0M | 106,349 | -2,500-2.35% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #29 | $500,168 | 97,309 | $933,418 | 98,670 | -1,361-1.38% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $464,723 | 90,413 | $578,261 | 61,127 | +29,286+47.91% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #20 | $423,192 | 82,333 | $1.1M | 115,818 | -33,485-28.91% | Reduce |
| Jump Financial, LLC |
| <0.01% | — | #12 | $398,350 | 77,500 | $0 | 0 | +77,500 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.03% | #7 | $258,840 | 50,358 | $544,000 | 57,538 | -7,180-12.48% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #47 | $254,666 | 49,546 | $404,406 | 42,749 | +6,797+15.90% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #11 | $210,226 | 40,900 | $510,840 | 54,000 | -13,100-24.26% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #56 | $198,641 | 38,646 | $364,607 | 38,542 | +104+0.27% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $181,946 | 35,398 | $386,167 | 40,821 | -5,423-13.28% | Reduce |
| Point72 Asset Management, L.P. |
| <0.01% | — | #34 | $137,613 | 26,773 | $0 | 0 | +26,773 | New Buy |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #54 | $116,800 | 23,360 | $124,676 | 17,560 | +5,800+33.03% | Add |
| XTX Topco Ltd |
| <0.01% | <0.01% | #17 | $112,181 | 21,825 | $210,286 | 22,229 | -404-1.82% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #74 | $109,932 | 18,507 | $59,699 | 6,738 | +11,769+174.67% | Add |
| Jain Global LLC |
| <0.01% | — | #24 | $109,482 | 21,300 | $0 | 0 | +21,300 | New Buy |
| Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | <0.01% | #48 | $106,532 | 20,726 | $108,724 | 11,493 | +9,233+80.34% | Add |
| RBF Capital, LLC |
| <0.01% | 0.01% | #10 | $102,800 | 20,000 | $189,200 | 20,000 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #72 | $102,085 | 19,861 | $292,967 | 30,969 | -11,108-35.87% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #45 | $96,688 | 18,812 | $173,854 | 18,379 | +433+2.36% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #69 | $85,797 | 16,692 | $80,618 | 8,522 | +8,170+95.87% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $84,476 | 16,435 | $129,243 | 13,662 | +2,773+20.30% | Add |
| PHILADELPHIA TRUST CO |
| <0.01% | 0.01% | #9 | $77,100 | 15,000 | $142,000 | 15,000 | 00.00% | Unchanged |
| Graham Capital Management, L.P. |
| <0.01% | — | #18 | $76,884 | 14,958 | $0 | 0 | +14,958 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #75 | $69,390 | 13,500 | $105,006 | 11,100 | +2,400+21.62% | Add |
| R Squared Ltd |
| 0.04% | 0.05% | #5 | $68,907 | 13,406 | $99,812 | 10,551 | +2,855+27.06% | Add |
| Arax Advisory Partners |
| <0.01% | <0.01% | #23 | $67,689 | 13,169 | $108,564 | 11,476 | +1,693+14.75% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #65 | $62,431 | 12,146 | $323,125 | 34,157 | -22,011-64.44% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #73 | $61,942 | 12,051 | $115,000 | 12,051 | 00.00% | Unchanged |
