| FMR LLC |
| <0.01% | <0.01% | #25 | $55.8M | 12.0M | $64.3M | 12.0M | +53,292+0.45% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $40.5M | 8.7M | $45.4M | 8.4M | +284,640+3.37% | Add |
| BML Capital Management, LLC |
| 18.44% | 24.38% | #1 | $32.3M | 7.0M | $38.0M | 7.1M | -106,327-1.51% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 1.02% | 1.32% | #4 | $22.4M | 4.8M | $25.9M | 4.8M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $13.8M | 3.0M | $17.5M | 3.2M | -281,262-8.66% | Reduce |
| Bain Capital Life Sciences Investors, LLC |
| 0.57% | 1.15% | #5 | $9.7M | 2.1M | $12.7M | 2.4M | -284,999-12.07% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #13 | $9.5M | 2.0M | $8.5M | 1.6M | +452,375+28.58% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #47 | $9.1M | 2.0M | $9.4M | 1.7M | +210,729+12.06% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $7.7M | 1.7M | $9.1M | 1.7M | -42,236-2.49% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #21 | $7.0M | 1.5M | $10.0M | 1.9M | -357,467-19.18% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #33 | $6.0M | 1.3M | $6.8M | 1.3M | +44,031+3.51% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #19 | $5.3M | 1.1M | $6.3M | 1.2M | -35,200-3.02% | Reduce |
| Rosalind Advisors, Inc. |
| 1.18% | 2.53% | #2 | $5.0M | 1.1M | $6.3M | 1.2M | -101,305-8.64% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #62 | $4.4M | 945,918 | $4.8M | 940,157 | +5,761+0.61% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #52 | $3.5M | 755,239 | $3.1M | 585,025 | +170,214+29.10% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $3.3M | 719,514 | $1.3M | 450,564 | +268,950+59.69% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $2.9M | 630,185 | $3.0M | 557,579 | +72,606+13.02% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #56 | $2.8M | 610,607 | $3.2M | 596,709 | +13,898+2.33% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $2.5M | 530,856 | $3.2M | 588,463 | -57,607-9.79% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $2.2M | 469,801 | $2.6M | 484,705 | -14,904-3.07% | Reduce |
| CM Management, LLC |
| 1.05% | 1.6% | #3 | $1.7M | 355,000 | $1.9M | 355,000 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #60 | $1.6M | 348,653 | $865,889 | 160,946 | +187,707+116.63% | Add |
| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #38 | $1.6M | 345,186 | $2.0M | 379,314 | -34,128-9.00% | Reduce |
| BANQUE PICTET & CIE SA |
| 0.01% | 0.01% | #15 | $1.6M | 345,077 | $1.9M | 345,077 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $1.4M | 304,611 | $1.9M | 349,932 | -45,321-12.95% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #59 | $1.3M | 284,283 | $1.3M | 243,103 | +41,180+16.94% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #81 | $1.2M | 267,125 | $717,412 | 133,348 | +133,777+100.32% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $1.2M | 247,710 | $248,067 | 46,109 | +201,601+437.23% | Add |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #31 | $1.1M | 242,302 | $85,811 | 15,950 | +226,352+1,419.13% | Add |
| Opaleye Management Inc. |
| 0.1% | 0.23% | #11 | $1.1M | 235,000 | $1.7M | 322,600 | -87,600-27.15% | Reduce |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #51 | $1.0M | 221,009 | $1.4M | 258,989 | -37,980-14.66% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #50 | $979,020 | 210,542 | $1.1M | 210,542 | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #71 | $961,551 | 206,785 | $306,708 | 57,009 | +149,776+262.72% | Add |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #74 | $880,952 | 189,452 | $999,631 | 185,805 | +3,647+1.96% | Add |
| Auour Investments LLC |
| 0.24% | 0.3% | #7 | $823,050 | 177,000 | $952,260 | 177,000 | 00.00% | Unchanged |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $793,555 | 170,657 | $899,697 | 167,230 | +3,427+2.05% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #86 | $731,092 | 157,224 | $375,529 | 69,801 | +87,423+125.25% | Add |
| ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #64 | $668,304 | 124,220 | $433,112 | 121,320 | +2,900+2.39% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.02% | #14 | $608,685 | 130,900 | $798,392 | 148,400 | -17,500-11.79% | Reduce |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #32 | $552,220 | 118,757 | $536,940 | 99,803 | +18,954+18.99% | Add |
| STRS OHIO |
| <0.01% | <0.01% | #27 | $547,305 | 117,700 | $518,632 | 96,400 | +21,300+22.10% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #96 | $538,507 | 115,808 | $574,000 | 106,562 | +9,246+8.68% | Add |
| Jump Financial, LLC |
| <0.01% | 0.01% | #23 | $476,258 | 102,421 | $501,669 | 93,247 | +9,174+9.84% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #94 | $439,457 | 94,507 | $591,531 | 109,950 | -15,443-14.05% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #58 | $423,720 | 91,124 | $479,101 | 89,054 | +2,070+2.32% | Add |
| Aldebaran Capital, LLC |
| 0.31% | 0.37% | #6 | $410,037 | 88,180 | $483,909 | 89,946 | -1,766-1.96% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #104 | $380,044 | 81,730 | $568,343 | 105,640 | -23,910-22.63% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #69 | $366,053 | 78,721 | $841,384 | 156,391 | -77,670-49.66% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #83 | $327,360 | 70,400 | $353,391 | 65,686 | +4,714+7.18% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #46 | $326,000 | 70,000 | $377,000 | 70,000 | 00.00% | Unchanged |
