| Samsara BioCapital, LLC |
| 0.65% | 0.61% | #1 | $7.9M | 10.4M | $6.2M | 8.5M | +1.9M+21.99% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 0.06% | 0.07% | #5 | $6.5M | 8.5M | $6.2M | 8.5M | 00.00% | Unchanged |
| AWM Investment Company, Inc. |
| 0.49% | 0.53% | #2 | $5.7M | 7.5M | $4.8M | 6.5M | +1.0M+15.38% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $3.5M | 4.6M | $3.4M | 4.6M | -59,582-1.29% | Reduce |
| Longaeva Partners L.P. |
| 0.04% | 0.06% | #6 | $1.8M | 2.3M | $1.7M | 2.3M | 00.00% | Unchanged |
| Polar Asset Management Partners Inc. |
| 0.03% | — | #8 | $1.8M | 2.3M | $0 | 0 | +2.3M | New Buy |
| Siren, L.L.C. |
| 0.03% | 0.04% | #7 | $1.5M | 2.0M | $1.5M | 2.0M | 00.00% | Unchanged |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.16% | — | #4 | $710,655 | 934,580 | $0 | 0 | +934,580 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $677,575 | 890,618 | $664,060 | 903,298 | -12,680-1.40% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #38 | $500,187 | 657,795 | $203,246 | 276,600 | +381,195+137.81% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #26 | $445,561 | 586,265 | $0 | 0 | +586,265 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #42 | $378,223 | 497,399 | $245,422 | 333,999 | +163,400+48.92% | Add |
| Nan Fung Group Holdings Ltd |
| 0.29% | 0.3% | #3 | $375,321 | 493,584 | $362,686 | 493,584 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #34 | $348,176 | 458,126 | $334,462 | 455,050 | +3,076+0.68% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #25 | $327,532 | 430,737 | $0 | 0 | +430,737 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #50 | $283,737 | 373,142 | $274,185 | 373,142 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $260,142 | 342,113 | $409,202 | 556,889 | -214,776-38.57% | Reduce |
| UNITED SERVICES AUTOMOBILE ASSOCIATION |
| 0.02% | 0.03% | #9 | $230,206 | 302,743 | $222,456 | 302,743 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #43 | $225,926 | 297,270 | $167,009 | 227,223 | +70,047+30.83% | Add |
| KESTRA PRIVATE WEALTH SERVICES, LLC |
| <0.01% | <0.01% | #18 | $214,691 | 282,340 | $194,839 | 265,159 | +17,181+6.48% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | <0.01% | #10 | $189,884 | 249,716 | $71,000 | 96,998 | +152,718+157.44% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $129,626 | 170,471 | $125,262 | 170,471 | 00.00% | Unchanged |
| CWA Asset Management Group, LLC |
| <0.01% | <0.01% | #14 | $114,060 | 150,000 | $110,220 | 150,000 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $87,066 | 114,500 | $84,135 | 114,500 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #52 | $60,208 | 79,190 | $1.1M | 1.4M | -1.4M-94.49% | Reduce |
| KING LUTHER CAPITAL MANAGEMENT CORP |
| <0.01% | <0.01% | #29 | $44,103 | 58,000 | $42,618 | 58,000 | 00.00% | Unchanged |
| Well Done, LLC |
| 0.01% | 0.01% | #11 | $39,552 | 52,014 | $38,220 | 52,014 | 00.00% | Unchanged |
| Janney Montgomery Scott LLC |
| <0.01% | <0.01% | #37 | $37,412 | 49,200 | $36,000 | 49,200 | 00.00% | Unchanged |
| MOTCO |
| <0.01% | <0.01% | #17 | $36,597 | 48,129 | $35,365 | 48,129 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #41 | $31,862 | 41,902 | $12,051 | 16,401 | +25,501+155.48% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $24,131 | 31,751 | $23,337 | 31,751 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $23,182 | 30,486 | $3,374 | 6,750 | +23,736+351.64% | Add |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #24 | $22,616 | 29,743 | $9,051 | 12,318 | +17,425+141.46% | Add |
| Lafayette Investments, Inc. |
| <0.01% | <0.01% | #16 | $17,474 | 22,979 | $16,885 | 22,979 | 00.00% | Unchanged |
| TRAPHAGEN INVESTMENT ADVISORS LLC |
| <0.01% | <0.01% | #22 | $16,748 | 22,024 | $16,184 | 22,024 | 00.00% | Unchanged |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| <0.01% | <0.01% | #36 | $15,740 | 20,700 | $57,314 | 78,000 | -57,300-73.46% | Reduce |
| Cerity Partners LLC |
| <0.01% | <0.01% | #45 | $14,516 | 19,090 | $14,027 | 19,090 | 00.00% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
| <0.01% | <0.01% | #44 | $14,486 | 19,051 | $7,717 | 10,502 | +8,549+81.40% | Add |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #23 | $13,601 | 17,887 | $12,720 | 17,311 | +576+3.33% | Add |
| J. Safra Sarasin Holding AG |
| <0.01% | — | #28 | $12,931 | 17,000 | $0 | 0 | +17,000 | New Buy |
| XTX Topco Ltd |
| <0.01% | — | #31 | $12,896 | 16,959 | $0 | 0 | +16,959 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #27 | $11,793 | 15,509 | $10,544 | 14,350 | +1,159+8.08% | Add |
| ACT Advisors, LLC. |
| <0.01% | <0.01% | #13 | $11,258 | 14,806 | $10,879 | 14,806 | 00.00% | Unchanged |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #58 | $10,554 | 13,879 | $10,199 | 13,879 | 00.00% | Unchanged |
| Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #33 | $10,494 | 13,800 | $11,115 | 13,800 | 00.00% | Unchanged |
| CLEAR WAVE WEALTH MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $10,058 | 13,228 | $9,720 | 13,228 | 00.00% | Unchanged |
| Disciplined Investors, L.L.C. |
| <0.01% | 0.01% | #12 | $9,277 | 12,200 | $8,965 | 12,200 | 00.00% | Unchanged |
| Sanctuary Advisors, LLC |
| <0.01% | <0.01% | #39 | $9,135 | 12,014 | $8,828 | 12,014 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $8,927 | 11,740 | $8,690 | 11,826 | -86-0.73% | Reduce |
| Rockefeller Capital Management L.P. |
| <0.01% | — | #47 | $8,779 | 11,545 | $0 | 0 | +11,545 | New Buy |
