| TANG CAPITAL MANAGEMENT LLC |
| 0.32% | 0.39% | #4 | $7.0M | 6.1M | $7.7M | 6.1M | -1,871-0.03% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.29% | 0.19% | #6 | $6.3M | 5.5M | $3.3M | 2.6M | +2.9M+113.13% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $2.8M | 2.4M | $3.0M | 2.3M | +97,250+4.15% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $2.8M | 2.4M | $3.0M | 2.4M | 00.00% | Unchanged |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $2.6M | 2.3M | $2.8M | 2.3M | +9,694+0.43% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $2.4M | 2.1M | $4.1M | 3.3M | -1.1M-34.36% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $2.3M | 2.0M | $2.3M | 1.9M | +197,032+10.63% | Add |
| Monaco Asset Management SAM |
| 0.18% | 0.45% | #10 | $2.2M | 1.9M | $2.4M | 1.9M | 00.00% | Unchanged |
| Lynx1 Capital Management LP |
| 0.4% | — | #3 | $2.0M | 1.8M | $0 | 0 | +1.8M | New Buy |
| BML Capital Management, LLC |
| 1.01% | 1.25% | #2 | $1.8M | 1.5M | $1.9M | 1.5M | 00.00% | Unchanged |
| Prosight Management, LP |
| 0.27% | 0.34% | #7 | $1.6M | 1.4M | $2.1M | 1.7M | -297,367-17.83% | Reduce |
| Peapod Lane Capital LLC |
| 1.01% | 1.3% | #1 | $1.5M | 1.3M | $1.6M | 1.3M | +20,435+1.59% | Add |
| Woodline Partners LP |
| <0.01% | 0.01% | #27 | $1.5M | 1.3M | $2.1M | 1.7M | -370,296-22.22% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $1.3M | 1.2M | $1.4M | 1.1M | +54,784+5.00% | Add |
| Ikarian Capital, LLC |
| 0.12% | — | #11 | $1.1M | 1.0M | $0 | 0 | +1.0M | New Buy |
| Eversept Partners, LP |
| 0.05% | 0.06% | #15 | $1.0M | 891,425 | $1.1M | 891,425 | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #36 | $952,041 | 835,124 | $1.3M | 995,973 | -160,849-16.15% | Reduce |
| Redmile Group, LLC |
| 0.06% | 0.06% | #14 | $880,224 | 772,126 | $972,879 | 772,126 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #52 | $783,894 | 681,647 | $1.0M | 861,823 | -180,176-20.91% | Reduce |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #31 | $733,157 | 643,120 | $905,364 | 718,543 | -75,423-10.50% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $659,954 | 578,577 | $526,154 | 417,274 | +161,303+38.66% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #45 | $651,806 | 571,760 | $1.3M | 1.1M | -486,194-45.96% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #40 | $637,770 | 559,447 | $1.5M | 1.2M | -621,071-52.61% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #24 | $631,138 | 553,630 | $697,574 | 553,630 | 00.00% | Unchanged |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #34 | $611,132 | 536,081 | $651,991 | 517,453 | +18,628+3.60% | Add |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #35 | $606,570 | 532,079 | $670,000 | 532,079 | 00.00% | Unchanged |
| DAFNA Capital Management LLC |
| 0.11% | 0.14% | #12 | $555,180 | 487,000 | $613,620 | 487,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| 0.01% | 0.01% | #25 | $502,562 | 440,844 | $631,056 | 500,838 | -59,994-11.98% | Reduce |
| Laurion Capital Management LP |
| 0.01% | 0.02% | #21 | $470,587 | 412,796 | $520,123 | 412,796 | 00.00% | Unchanged |
| TORNO CAPITAL, LLC |
| 0.01% | 0.06% | #23 | $400,647 | 351,445 | $441,000 | 350,000 | +1,445+0.41% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $389,596 | 341,751 | $427,820 | 339,540 | +2,211+0.65% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | — | #26 | $345,420 | 303,000 | $0 | 0 | +303,000 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $340,833 | 298,976 | $5.2M | 3.5M | -3.2M-91.48% | Reduce |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #38 | $338,909 | 297,291 | $374,583 | 297,291 | 00.00% | Unchanged |
| Verdad Advisers, LP |
| 0.31% | 0.14% | #5 | $320,731 | 281,343 | $123,883 | 98,320 | +183,023+186.15% | Add |
| ArrowMark Colorado Holdings LLC |
| 0.01% | 0.01% | #20 | $320,555 | 281,189 | $354,298 | 281,189 | 00.00% | Unchanged |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.24% | 0.32% | #9 | $313,500 | 275,000 | $346,500 | 275,000 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $288,897 | 253,418 | $319,307 | 253,418 | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 0.04% | 0.11% | #17 | $262,813 | 230,538 | $283,059 | 224,650 | +5,888+2.62% | Add |
| Rangeley Capital, LLC |
| 0.24% | 0.28% | #8 | $256,500 | 225,000 | $283,500 | 225,000 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #56 | $237,787 | 208,585 | $752,014 | 596,837 | -388,252-65.05% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #59 | $232,504 | 203,951 | $465,311 | 369,294 | -165,343-44.77% | Reduce |
| Marquette Asset Management, LLC |
| 0.03% | — | #19 | $198,930 | 174,500 | $0 | 0 | +174,500 | New Buy |
| HighMark Wealth Management LLC |
| 0.06% | 0.09% | #13 | $189,495 | 166,224 | $209,442 | 166,224 | 00.00% | Unchanged |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.03% | #22 | $184,915 | 162,206 | $507,000 | 402,092 | -239,886-59.66% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #70 | $175,232 | 153,712 | $193,801 | 153,810 | -98-0.06% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #61 | $142,568 | 125,060 | $194,263 | 154,176 | -29,116-18.88% | Reduce |
| ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #33 | $140,678 | 123,402 | $106,000 | 84,452 | +38,950+46.12% | Add |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #41 | $131,013 | 114,924 | $144,804 | 114,924 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #65 | $119,333 | 104,678 | $145,175 | 115,218 | -10,540-9.15% | Reduce |
