| MORGAN STANLEY |
| <0.01% | <0.01% | #28 | $44.2M | 9.5M | $12,750 | 3,728 | +9.5M+253,689.67% | Add |
| FMR LLC |
| <0.01% | <0.01% | #31 | $38.9M | 8.3M | $33.5M | 8.1M | +218,257+2.69% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 2.21% | 2.97% | #6 | $37.2M | 8.0M | $32.9M | 8.0M | 00.00% | Unchanged |
| PERCEPTIVE ADVISORS LLC |
| 0.56% | 0.54% | #10 | $37.0M | 7.9M | $27.8M | 6.7M | +1.2M+17.75% | Add |
| Saturn V Capital Management LP |
| 4.67% | 4.83% | #3 | $32.6M | 7.0M | $26.7M | 6.5M | +516,697+8.00% | Add |
| Empery Asset Management, LP |
| 37.43% | 44.5% | #1 | $32.4M | 6.9M | $36.9M | 8.9M | -2.0M-22.51% | Reduce |
| Deep Track Capital, LP |
| 0.4% | 0.43% | #13 | $27.5M | 5.9M | $26.2M | 6.3M | -460,778-7.27% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $25.9M | 5.6M | $5.0M | 1.2M | +4.3M+358.40% | Add |
| Kalehua Capital Management LLC |
| 12.46% | 10.88% | #2 | $17.4M | 3.7M | $15.4M | 3.7M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #43 | $17.4M | 3.7M | $14.4M | 3.5M | +218,247+6.24% | Add |
| NEA Management Company, LLC |
| 0.95% | 0.76% | #9 | $15.1M | 3.2M | $13.4M | 3.2M | 00.00% | Unchanged |
| Rosalind Advisors, Inc. |
| 3.56% | 5.33% | #5 | $15.0M | 3.2M | $13.3M | 3.2M | 00.00% | Unchanged |
| BRAIDWELL LP |
| 0.5% | 0.45% | #12 | $13.6M | 2.9M | $13.5M | 3.3M | -350,200-10.70% | Reduce |
| Blackstone Inc. |
| 0.04% | 0.04% | #19 | $12.5M | 2.7M | $11.1M | 2.7M | 00.00% | Unchanged |
| Trails Edge Capital Partners, LP |
| 1.91% | 2.43% | #7 | $12.0M | 2.6M | $10.6M | 2.6M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.38% | 0.37% | #14 | $11.4M | 2.4M | $10.1M | 2.4M | 00.00% | Unchanged |
| BVF INC/IL |
| 0.27% | 0.29% | #16 | $10.4M | 2.2M | $9.2M | 2.2M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #39 | $9.8M | 2.1M | $3.9M | 939,726 | +1.2M+123.26% | Add |
| Venrock Adviser, LLC |
| 0.27% | 0.05% | #15 | $9.0M | 1.9M | $1.4M | 330,525 | +1.6M+485.21% | Add |
| Samsara BioCapital, LLC |
| 0.54% | 0.74% | #11 | $6.5M | 1.4M | $7.6M | 1.8M | -436,979-23.85% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #49 | $6.1M | 1.3M | $1.7M | 403,534 | +892,483+221.17% | Add |
| Woodline Partners LP |
| 0.01% | 0.02% | #22 | $4.7M | 1.0M | $4.1M | 1.0M | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #42 | $4.3M | 916,536 | $3.6M | 882,134 | +34,402+3.90% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $3.0M | 652,849 | $736,111 | 178,235 | +474,614+266.29% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #38 | $2.7M | 572,038 | $2.0M | 480,733 | +91,305+18.99% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #56 | $2.5M | 542,128 | $0 | 0 | +542,128 | New Buy |
| Verdad Advisers, LP |
| 1.57% | — | #8 | $1.6M | 352,093 | $0 | 0 | +352,093 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #60 | $1.2M | 264,350 | $3.5M | 856,222 | -591,872-69.13% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #50 | $1.2M | 263,264 | $275,673 | 66,749 | +196,515+294.41% | Add |
| Caption Management, LLC |
| 0.01% | — | #26 | $1.2M | 250,000 | $0 | 0 | +250,000 | New Buy |
| Stonepine Capital Management, LLC |
| 0.16% | 0.55% | #17 | $1.1M | 224,989 | $1.4M | 335,309 | -110,320-32.90% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #52 | $916,908 | 196,340 | $0 | 0 | +196,340 | New Buy |
| Affinity Asset Advisors, LLC |
| 0.03% | 0.03% | #20 | $677,150 | 145,000 | $598,850 | 145,000 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | — | #54 | $501,507 | 107,389 | $0 | 0 | +107,389 | New Buy |
| Invesco Ltd. |
| <0.01% | <0.01% | #72 | $451,926 | 96,772 | $82,468 | 19,968 | +76,804+384.64% | Add |
| ALPS ADVISORS INC |
| <0.01% | — | #30 | $447,040 | 95,726 | $0 | 0 | +95,726 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #46 | $444,022 | 95,081 | $0 | 0 | +95,081 | New Buy |
| Susquehanna Portfolio Strategies, LLC |
| 0.01% | 0.01% | #25 | $407,607 | 87,282 | $423,734 | 102,599 | -15,317-14.93% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #58 | $368,393 | 78,885 | $0 | 0 | +78,885 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | — | #21 | $356,386 | 76,314 | $0 | 0 | +76,314 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | — | #51 | $349,293 | 74,795 | $0 | 0 | +74,795 | New Buy |
| CITIGROUP INC |
| <0.01% | <0.01% | #57 | $327,423 | 70,112 | $147,709 | 35,765 | +34,347+96.04% | Add |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #68 | $316,215 | 67,712 | $0 | 0 | +67,712 | New Buy |
| Palumbo Wealth Management LLC |
| 0.07% | 0.13% | #18 | $313,432 | 67,116 | $541,088 | 131,014 | -63,898-48.77% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | — | #45 | $313,254 | 67,078 | $0 | 0 | +67,078 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #74 | $309,990 | 66,379 | $0 | 0 | +66,379 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #73 | $271,060 | 58,043 | $1.1M | 267,340 | -209,297-78.29% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | — | #69 | $241,906 | 51,800 | $0 | 0 | +51,800 | New Buy |
| MetLife Investment Management, LLC |
| <0.01% | — | #33 | $224,015 | 47,969 | $0 | 0 | +47,969 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #79 | $218,841 | 46,861 | $622,292 | 150,676 | -103,815-68.90% | Reduce |
