| Madryn Asset Management, LP |
| 78.5% | 78.5% | #1 | $26.8M | 18.5M | $26.8M | 18.5M | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #31 | $3.0M | 2.3M | $4.2M | 2.9M | -591,499-20.61% | Reduce |
| WEXFORD CAPITAL LP |
| 0.33% | 0.15% | #5 | $2.6M | 2.0M | $1.0M | 700,961 | +1.3M+185.70% | Add |
| FourWorld Capital Management LLC |
| 2.23% | 1.1% | #2 | $2.3M | 1.7M | $2.2M | 1.5M | +254,820+17.11% | Add |
| Lane Generational LLC |
| 1.86% | 2.05% | #3 | $2.1M | 1.6M | $2.6M | 1.8M | -141,252-7.96% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #48 | $2.0M | 1.5M | $3.0M | 2.0M | -540,878-26.41% | Reduce |
| MASTERS CAPITAL MANAGEMENT LLC |
| 0.03% | 0.05% | #10 | $1.3M | 1.0M | $1.5M | 1.0M | 00.00% | Unchanged |
| AdvisorShares Investments LLC |
| 0.12% | 0.16% | #6 | $965,634 | 742,795 | $894,930 | 617,193 | +125,602+20.35% | Add |
| Ikarian Capital, LLC |
| 0.1% | 0.08% | #7 | $911,537 | 701,182 | $1.0M | 701,182 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #62 | $775,608 | 596,622 | $3.4M | 2.3M | -1.7M-74.27% | Reduce |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #26 | $732,863 | 563,741 | $815,437 | 562,370 | +1,371+0.24% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #29 | $631,400 | 485,692 | $0 | 0 | +485,692 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #50 | $596,242 | 458,474 | $1.4M | 958,989 | -500,515-52.19% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #45 | $565,114 | 434,703 | $133,396 | 91,997 | +342,706+372.52% | Add |
| Dauntless Investment Group, LLC |
| 0.38% | 0.26% | #4 | $479,943 | 369,187 | $390,352 | 269,208 | +99,979+37.14% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #63 | $377,389 | 290,299 | $1.2M | 842,547 | -552,248-65.55% | Reduce |
| Centiva Capital, LP |
| <0.01% | <0.01% | #18 | $371,687 | 285,913 | $245,513 | 169,319 | +116,594+68.86% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $344,154 | 264,734 | $374,149 | 258,034 | +6,700+2.60% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #52 | $343,314 | 264,088 | $338,705 | 233,590 | +30,498+13.06% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #54 | $343,139 | 263,953 | $200,942 | 138,581 | +125,372+90.47% | Add |
| JBF Capital, Inc. |
| 0.04% | 0.05% | #9 | $303,116 | 233,166 | $338,091 | 233,166 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | <0.01% | #16 | $286,420 | 220,323 | $211,925 | 146,155 | +74,168+50.75% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #56 | $259,285 | 199,450 | $44,622 | 30,774 | +168,676+548.11% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #43 | $259,285 | 199,450 | $0 | 0 | +199,450 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $246,042 | 189,263 | $274,431 | 189,263 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #42 | $193,460 | 148,815 | $12,028 | 8,295 | +140,520+1,694.03% | Add |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | — | #37 | $162,319 | 124,861 | $0 | 0 | +124,861 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $153,168 | 117,822 | $169,187 | 116,680 | +1,142+0.98% | Add |
| ADAR1 Capital Management, LLC |
| 0.01% | 0.01% | #14 | $130,000 | 100,000 | $145,000 | 100,000 | 00.00% | Unchanged |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $123,767 | 95,205 | $138,047 | 95,205 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #40 | $123,001 | 94,616 | $54,543 | 37,616 | +57,000+151.53% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $115,880 | 89,138 | $402,198 | 277,378 | -188,240-67.86% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #38 | $115,323 | 88,710 | $145,000 | 100,620 | -11,910-11.84% | Reduce |
| GAMCO INVESTORS, INC. ET AL |
| <0.01% | <0.01% | #25 | $102,960 | 79,200 | $114,840 | 79,200 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #67 | $88,842 | 68,340 | $104,954 | 72,382 | -4,042-5.58% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #69 | $88,653 | 68,195 | $142,238 | 98,095 | -29,900-30.48% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #71 | $81,762 | 62,893 | $1.3M | 475,710 | -412,817-86.78% | Reduce |
| Engineers Gate Manager LP |
| <0.01% | — | #24 | $74,328 | 57,175 | $0 | 0 | +57,175 | New Buy |
| VestGen Advisors, LLC |
| <0.01% | <0.01% | #21 | $65,363 | 50,279 | $127,525 | 100,413 | -50,134-49.93% | Reduce |
| Cruiser Capital Advisors, LLC |
| 0.06% | 0.04% | #8 | $63,570 | 48,900 | $70,905 | 48,900 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| 0.01% | — | #12 | $53,716 | 41,320 | $0 | 0 | +41,320 | New Buy |
| Arax Advisory Partners |
| <0.01% | <0.01% | #32 | $51,796 | 39,843 | $56,728 | 39,123 | +720+1.84% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | — | #57 | $49,958 | 37,847 | $0 | 0 | +37,847 | New Buy |
| GABELLI FUNDS LLC |
| <0.01% | <0.01% | #34 | $49,400 | 38,000 | $55,100 | 38,000 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | — | #33 | $40,113 | 30,856 | $0 | 0 | +30,856 | New Buy |
| Virtu Financial LLC |
| <0.01% | — | #23 | $38,457 | 29,582 | $0 | 0 | +29,582 | New Buy |
| David J Yvars Group |
| 0.02% | 0.02% | #11 | $35,815 | 27,550 | $29,435 | 20,300 | +7,250+35.71% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #73 | $31,520 | 24,246 | $54,000 | 36,861 | -12,615-34.22% | Reduce |
| State of Wyoming |
| <0.01% | — | #19 | $30,527 | 23,482 | $0 | 0 | +23,482 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | — | #53 | $30,174 | 23,211 | $0 | 0 | +23,211 | New Buy |
