| DAFNA Capital Management LLC |
| 4.49% | 5.73% | #1 | $23.5M | 13.7M | $25.2M | 13.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #48 | $7.6M | 4.4M | $7.3M | 4.0M | +440,592+11.14% | Add |
| Lagoda Investment Management, L.P. |
| 3.9% | 4.94% | #2 | $7.1M | 4.1M | $8.0M | 4.4M | -227,800-5.24% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $5.2M | 3.0M | $5.5M | 3.0M | +46,776+1.56% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #41 | $3.3M | 1.9M | $3.1M | 1.7M | +219,835+13.12% | Add |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 0.34% | 0.46% | #6 | $2.6M | 1.5M | $2.9M | 1.6M | -68,135-4.28% | Reduce |
| Archon Capital Management LLC |
| 0.86% | 1.27% | #4 | $2.1M | 1.2M | $2.3M | 1.2M | 00.00% | Unchanged |
| Warberg Asset Management LLC |
| 0.35% | 0.34% | #5 | $1.9M | 1.1M | $2.0M | 1.1M | +14,766+1.35% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #58 | $1.6M | 916,780 | $1.8M | 957,768 | -40,988-4.28% | Reduce |
| AlphaCentric Advisors LLC |
| 0.87% | 1.1% | #3 | $1.0M | 600,000 | $1.1M | 600,000 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #39 | $1.0M | 589,110 | $974,961 | 529,870 | +59,240+11.18% | Add |
| Bank Julius Baer & Co. Ltd, Zurich |
| <0.01% | <0.01% | #26 | $929,710 | 540,530 | $994,573 | 540,529 | +1+0.00% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #49 | $911,076 | 529,695 | $914,344 | 496,926 | +32,769+6.59% | Add |
| Legato Capital Management LLC |
| 0.07% | — | #7 | $882,200 | 512,907 | $0 | 0 | +512,907 | New Buy |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #63 | $797,358 | 463,580 | $678,277 | 368,629 | +94,951+25.76% | Add |
| Sequoia Financial Advisors, LLC |
| <0.01% | <0.01% | #25 | $655,931 | 381,355 | $700,400 | 380,652 | +703+0.18% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $571,226 | 332,107 | $366,138 | 117,728 | +214,379+182.10% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #56 | $432,293 | 251,333 | $436,592 | 237,278 | +14,055+5.92% | Add |
| PRESCOTT GROUP CAPITAL MANAGEMENT, L.L.C. |
| 0.04% | 0.04% | #9 | $408,491 | 237,495 | $436,991 | 237,495 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #64 | $404,151 | 234,971 | $495,044 | 269,046 | -34,075-12.67% | Reduce |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #32 | $403,533 | 234,612 | $954,747 | 518,884 | -284,272-54.79% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #54 | $364,022 | 211,641 | $360,596 | 195,976 | +15,665+7.99% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #60 | $360,662 | 209,687 | $43,240 | 23,500 | +186,187+792.29% | Add |
| Independent Advisor Alliance |
| 0.01% | <0.01% | #18 | $358,593 | 208,485 | $369,813 | 200,985 | +7,500+3.73% | Add |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #46 | $338,190 | 196,622 | $120,099 | 65,271 | +131,351+201.24% | Add |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #20 | $298,893 | 173,775 | $407,514 | 221,475 | -47,700-21.54% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #59 | $284,000 | 165,363 | $297,000 | 161,183 | +4,180+2.59% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #66 | $247,966 | 144,166 | $317,854 | 172,747 | -28,581-16.55% | Reduce |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #72 | $242,007 | 140,702 | $216,000 | 116,921 | +23,781+20.34% | Add |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #42 | $223,665 | 130,042 | $243,522 | 132,353 | -2,311-1.75% | Reduce |
| GMT CAPITAL CORP |
| 0.01% | 0.01% | #15 | $217,719 | 126,581 | $232,909 | 126,581 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #86 | $201,787 | 117,318 | $91,534 | 49,747 | +67,571+135.83% | Add |
| Kovack Advisors, Inc. |
| 0.01% | 0.01% | #17 | $178,970 | 101,113 | $201,472 | 108,904 | -7,791-7.15% | Reduce |
| ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $157,514 | 91,578 | $249,820 | 135,772 | -44,194-32.55% | Reduce |
| Leonteq Securities AG |
| <0.01% | 0.01% | #23 | $128,990 | 74,994 | $137,989 | 74,994 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | <0.01% | #67 | $127,263 | 73,990 | $136,142 | 73,990 | 00.00% | Unchanged |
| TCFG Investment Advisors, LLC |
| 0.04% | 0.04% | #8 | $118,706 | 69,015 | $117,788 | 64,015 | +5,000+7.81% | Add |
| WEALTH EFFECTS LLC |
| 0.03% | 0.04% | #10 | $117,820 | 68,500 | $126,040 | 68,500 | 00.00% | Unchanged |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #57 | $116,629 | 68,605 | $124,861 | 68,605 | 00.00% | Unchanged |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #65 | $116,164 | 67,537 | $1,869 | 1,016 | +66,521+6,547.34% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #74 | $115,137 | 66,940 | $124,800 | 67,826 | -886-1.31% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #77 | $106,968 | 62,191 | $41,633 | 22,627 | +39,564+174.85% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $86,962 | 50,559 | $199,059 | 108,184 | -57,625-53.27% | Reduce |
| Cherry Creek Investment Advisors, Inc. |
| 0.03% | 0.03% | #11 | $73,275 | 42,602 | $66,637 | 36,216 | +6,386+17.63% | Add |
| Wellington Shields & Co., LLC |
| 0.02% | 0.02% | #13 | $68,936 | 40,079 | $73,745 | 40,079 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #95 | $66,340 | 38,570 | $48,609 | 26,418 | +12,152+46.00% | Add |
| Verition Fund Management LLC |
| <0.01% | <0.01% | #52 | $60,200 | 35,000 | $40,480 | 22,000 | +13,000+59.09% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #71 | $59,154 | 34,392 | $63,281 | 34,392 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #76 | $55,036 | 31,998 | $6,143 | 3,339 | +28,659+858.31% | Add |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | <0.01% | #53 | $53,996 | 31,393 | $53,178 | 28,901 | +2,492+8.62% | Add |
