| RA CAPITAL MANAGEMENT, L.P. |
| 0.01% | 0.06% | #6 | $859,349 | 2.4M | $5.6M | 6.7M | -4.3M-64.26% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #11 | $644,253 | 1.8M | $0 | 0 | +1.8M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #25 | $438,471 | 1.2M | $1.0M | 1.2M | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #16 | $242,800 | 674,632 | $429,803 | 516,218 | +158,414+30.69% | Add |
| Lynx1 Capital Management LP |
| 0.05% | 0.09% | #3 | $236,737 | 657,786 | $547,673 | 657,786 | 00.00% | Unchanged |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.03% | 0.08% | #5 | $225,589 | 626,810 | $521,882 | 626,810 | 00.00% | Unchanged |
| DC Funds, LP |
| 16.92% | 33.01% | #1 | $212,018 | 589,102 | $490,486 | 589,102 | 00.00% | Unchanged |
| Verdad Advisers, LP |
| 0.12% | 0.03% | #2 | $125,500 | 348,709 | $24,778 | 29,760 | +318,949+1,071.74% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #30 | $120,895 | 335,815 | $324,363 | 389,487 | -53,672-13.78% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #28 | $111,829 | 311,502 | $220,133 | 264,583 | +46,919+17.73% | Add |
| XTX Topco Ltd |
| <0.01% | <0.01% | #9 | $97,705 | 271,478 | $42,403 | 50,929 | +220,549+433.05% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #27 | $90,637 | 251,837 | $68,969 | 82,836 | +169,001+204.02% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #24 | $77,702 | 215,838 | $55,692 | 66,857 | +148,981+222.84% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #23 | $56,781 | 157,726 | $131,386 | 157,726 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #35 | $42,889 | 119,168 | $99,219 | 119,168 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| <0.01% | — | #22 | $37,157 | 103,242 | $0 | 0 | +103,242 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $36,556 | 101,573 | $84,598 | 101,608 | -35-0.03% | Reduce |
| Rangeley Capital, LLC |
| 0.03% | — | #4 | $35,990 | 100,000 | $0 | 0 | +100,000 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #31 | $32,571 | 90,500 | $8,644 | 10,382 | +80,118+771.70% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #33 | $31,258 | 86,851 | $72,312 | 86,851 | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #21 | $31,151 | 86,554 | $72,065 | 86,554 | 00.00% | Unchanged |
| MPM BioImpact LLC |
| <0.01% | 0.08% | #8 | $28,851 | 80,142 | $1.0M | 1.2M | -1.1M-93.37% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $22,334 | 62,055 | $109,945 | 132,050 | -69,995-53.01% | Reduce |
| Virtu Financial LLC |
| <0.01% | — | #14 | $16,364 | 45,467 | $0 | 0 | +45,467 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #29 | $9,825 | 27,300 | $0 | 0 | +27,300 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| <0.01% | — | #12 | $9,770 | 27,146 | $0 | 0 | +27,146 | New Buy |
| StoneX Group Inc. |
| <0.01% | — | #15 | $9,000 | 20,000 | $0 | 0 | +20,000 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #40 | $7,206 | 20,023 | $31,860 | 38,266 | -18,243-47.67% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #42 | $6,877 | 19,108 | $37,926 | 19,252 | -144-0.75% | Reduce |
| CERTUITY, LLC |
| <0.01% | <0.01% | #17 | $5,399 | 15,000 | $12,489 | 15,000 | 00.00% | Unchanged |
| HBK Sorce Advisory LLC |
| <0.01% | <0.01% | #19 | $5,317 | 13,227 | $8,994 | 13,227 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #38 | $4,763 | 13,235 | $11,020 | 13,235 | 00.00% | Unchanged |
| Larson Financial Group LLC |
| <0.01% | <0.01% | #18 | $4,697 | 13,052 | $10,867 | 13,052 | 00.00% | Unchanged |
| LPL Financial LLC |
| <0.01% | <0.01% | #36 | $4,244 | 11,791 | $8,326 | 10,000 | +1,791+17.91% | Add |
| Ranch Capital Advisors Inc. |
| <0.01% | <0.01% | #10 | $3,959 | 11,000 | $9,991 | 12,000 | -1,000-8.33% | Reduce |
| Marest Capital, LLC |
| <0.01% | — | #7 | $3,912 | 10,870 | $0 | 0 | +10,870 | New Buy |
| Cetera Investment Advisers |
| <0.01% | <0.01% | #34 | $3,671 | 10,200 | $8,493 | 10,200 | 00.00% | Unchanged |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #20 | $3,562 | 9,897 | $0 | 0 | +9,897 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #32 | $3,105 | 8,625 | $7,159 | 8,625 | 00.00% | Unchanged |
| Financial Perspectives, Inc |
| <0.01% | <0.01% | #13 | $2,429 | 6,750 | $5,620 | 6,750 | 00.00% | Unchanged |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #37 | $673 | 1,871 | $1,558 | 1,871 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #45 | $650 | 2,108 | $1,670 | 2,096 | +12+0.57% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #43 | $284 | 790 | $658 | 790 | 00.00% | Unchanged |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #44 | $91 | 255 | $27,094 | 32,526 | -32,271-99.22% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #39 | $36 | 100 | $67 | 80 | +20+25.00% | Add |
| Optiver Holding B.V. |
| <0.01% | <0.01% | #46 | $8 | 22 | $18 | 22 | 00.00% | Unchanged |
