| D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #21 | $6.7M | 41.0M | $127,928 | 389,431 | +40.6M+10,417.73% | Add |
| 683 Capital Management, LLC |
| 0.32% | 0.09% | #3 | $6.5M | 39.2M | $1.6M | 5.0M | +34.2M+683.98% | Add |
| DeepCurrents Investment Group LLC |
| 0.21% | — | #4 | $6.0M | 37.7M | $0 | 0 | +37.7M | New Buy |
| Context Capital Management, LLC |
| 0.09% | — | #12 | $4.8M | 28.9M | $0 | 0 | +28.9M | New Buy |
| Worth Venture Partners, LLC |
| 8.71% | — | #1 | $4.1M | 25.0M | $0 | 0 | +25.0M | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $2.6M | 15.6M | $3.3M | 10.1M | +5.5M+54.34% | Add |
| GSA CAPITAL PARTNERS LLP |
| 0.16% | 0.07% | #6 | $2.5M | 15.0M | $1.1M | 3.3M | +11.7M+360.54% | Add |
| WOLVERINE ASSET MANAGEMENT LLC |
| 0.02% | <0.01% | #13 | $2.1M | 12.9M | $2,956 | 9,000 | +12.9M+143,174.96% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $1.9M | 11.6M | $400,070 | 1.2M | +10.4M+854.94% | Add |
| Kalehua Capital Management LLC |
| 1.32% | 2.38% | #2 | $1.8M | 11.1M | $3.4M | 10.2M | +913,070+8.92% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #104 | $1.6M | 9.4M | $3.1M | 9.4M | +21,430+0.23% | Add |
| ARCH Venture Management, LLC |
| 0.12% | 0.39% | #7 | $1.3M | 8.1M | $2.6M | 8.1M | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $1.3M | 7.8M | $1.0M | 3.1M | +4.8M+155.48% | Add |
| Octagon Capital Advisors LP |
| 0.11% | 0.28% | #8 | $1.3M | 7.8M | $2.5M | 7.8M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #122 | $1.3M | 7.7M | $5.5M | 16.8M | -9.2M-54.42% | Reduce |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | — | #50 | $1.2M | 7.6M | $0 | 0 | +7.6M | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #43 | $1.2M | 7.4M | $1.6M | 4.8M | +2.7M+55.45% | Add |
| Samsara BioCapital, LLC |
| 0.1% | 0.23% | #10 | $1.2M | 7.2M | $2.4M | 7.2M | 00.00% | Unchanged |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #38 | $1.2M | 7.1M | $1.6M | 4.9M | +2.1M+43.68% | Add |
| Corient Private Wealth LLC |
| <0.01% | <0.01% | #47 | $925,959 | 5.6M | $1.3M | 4.0M | +1.6M+41.15% | Add |
| Siren, L.L.C. |
| 0.02% | 0.05% | #14 | $857,396 | 5.2M | $1.7M | 5.2M | 00.00% | Unchanged |
| Hillhouse Capital Advisors, Ltd. |
| 0.1% | 0.1% | #9 | $818,727 | 5.0M | $1.6M | 5.0M | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #89 | $510,474 | 3.1M | $619,699 | 1.9M | +1.2M+64.25% | Add |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #54 | $420,780 | 2.6M | $1.1M | 3.4M | -842,379-24.78% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #115 | $408,706 | 2.5M | $1.6M | 4.9M | -2.5M-49.76% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #74 | $395,473 | 2.4M | $61,567 | 187,418 | +2.2M+1,181.96% | Add |
| MB Generational Wealth, LLC |
| 0.18% | 0.28% | #5 | $364,992 | 2.2M | $503,309 | 1.5M | +685,309+44.73% | Add |
| JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #35 | $360,046 | 2.2M | $556,860 | 1.7M | +492,243+29.04% | Add |
| MARSHALL WACE, LLP |
| <0.01% | — | #64 | $338,399 | 2.1M | $0 | 0 | +2.1M | New Buy |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #44 | $337,667 | 2.1M | $673,899 | 2.1M | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $294,985 | 1.8M | $1.7M | 5.3M | -3.5M-66.04% | Reduce |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #77 | $267,389 | 1.6M | $37,806 | 113,943 | +1.5M+1,289.39% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #121 | $256,298 | 1.6M | $524,124 | 1.6M | +1,976+0.12% | Add |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #56 | $238,831 | 1.5M | $559,148 | 1.7M | -251,146-14.75% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $205,490 | 1.2M | $462,010 | 1.4M | -158,893-11.31% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #135 | $201,495 | 1.2M | $29,661 | 92,690 | +1.1M+1,225.53% | Add |
| DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #93 | $188,095 | 1.1M | $430,942 | 1.3M | -199,445-15.27% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #126 | $185,743 | 1.1M | $387,809 | 1.2M | -52,093-4.41% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #147 | $183,483 | 1.1M | $1.4M | 4.4M | -3.3M-74.60% | Reduce |
| Hennion & Walsh Asset Management, Inc. |
| 0.01% | 0.01% | #18 | $180,881 | 1.1M | $272,234 | 828,719 | +270,195+32.60% | Add |
| NEA Management Company, LLC |
| 0.01% | 0.02% | #15 | $164,600 | 1.0M | $328,500 | 1.0M | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $163,370 | 992,527 | $496,060 | 1.5M | -517,549-34.27% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #84 | $152,584 | 927,000 | $241,546 | 735,300 | +191,700+26.07% | Add |
| SMITH, MOORE & CO. |
| 0.01% | 0.01% | #16 | $148,140 | 900,000 | $154,395 | 470,000 | +430,000+91.49% | Add |
| Ishara Investments LP |
| 0.1% | 0.26% | #11 | $134,972 | 820,000 | $269,370 | 820,000 | 00.00% | Unchanged |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #57 | $120,687 | 733,216 | $154,377 | 469,946 | +263,270+56.02% | Add |
| Mariner, LLC |
| <0.01% | <0.01% | #80 | $97,889 | 594,719 | $137,446 | 418,404 | +176,315+42.14% | Add |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #55 | $97,321 | 591,254 | $129,343 | 393,739 | +197,515+50.16% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $89,795 | 544,212 | $710,995 | 2.2M | -1.6M-74.82% | Reduce |
| CHOREO, LLC |
| <0.01% | <0.01% | #40 | $88,902 | 540,111 | $82,161 | 250,111 | +290,000+115.95% | Add |
