| Samsara BioCapital, LLC |
| 4.31% | 7.26% | #1 | $52.4M | 12.9M | $74.7M | 12.9M | -66,906-0.52% | Reduce |
| RTW INVESTMENTS, LP |
| 0.05% | 0.07% | #6 | $5.3M | 1.3M | $7.5M | 1.3M | 00.00% | Unchanged |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #14 | $2.3M | 572,687 | $3.3M | 572,687 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.04% | 0.07% | #9 | $1.8M | 435,798 | $2.5M | 435,798 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $1.6M | 398,712 | $1.5M | 255,348 | +143,364+56.14% | Add |
| Ikarian Capital, LLC |
| 0.16% | 0.17% | #4 | $1.5M | 360,000 | $2.1M | 360,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #31 | $1.1M | 262,131 | $35,682 | 6,184 | +255,947+4,138.86% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $607,859 | 149,351 | $381,691 | 66,151 | +83,200+125.77% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #26 | $566,549 | 139,201 | $391,662 | 67,879 | +71,322+105.07% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $464,287 | 114,037 | $505,341 | 87,545 | +26,492+30.26% | Add |
| Woodline Partners LP |
| <0.01% | <0.01% | #21 | $407,000 | 100,000 | $577,000 | 100,000 | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.03% | #10 | $407,000 | 100,000 | $577,000 | 100,000 | 00.00% | Unchanged |
| WHI TRUST Co LLC |
| 0.26% | 0.42% | #3 | $396,797 | 97,493 | $562,535 | 97,493 | 00.00% | Unchanged |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #32 | $395,457 | 97,164 | $685,978 | 118,887 | -21,723-18.27% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $389,792 | 95,772 | $0 | 0 | +95,772 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #16 | $375,502 | 92,261 | $532,346 | 92,261 | 00.00% | Unchanged |
| Verdad Advisers, LP |
| 0.31% | — | #2 | $326,809 | 80,297 | $0 | 0 | +80,297 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #41 | $294,367 | 72,326 | $144,026 | 24,918 | +47,408+190.26% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $269,349 | 66,179 | $211,857 | 36,717 | +29,462+80.24% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $221,580 | 54,442 | $207,968 | 36,043 | +18,399+51.05% | Add |
| Belpointe Asset Management LLC |
| 0.01% | 0.01% | #15 | $162,800 | 40,000 | $230,800 | 40,000 | 00.00% | Unchanged |
| Fortis Capital Advisors, LLC |
| 0.02% | 0.03% | #12 | $162,800 | 40,000 | $230,800 | 40,000 | 00.00% | Unchanged |
| Pale Fire Capital SE |
| 0.01% | — | #13 | $161,278 | 39,626 | $0 | 0 | +39,626 | New Buy |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #30 | $157,814 | 38,775 | $229,490 | 39,773 | -998-2.51% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #18 | $132,275 | 32,500 | $129,825 | 22,500 | +10,000+44.44% | Add |
| Stonepine Capital Management, LLC |
| 0.02% | 0.05% | #11 | $122,597 | 30,122 | $117,708 | 20,400 | +9,722+47.66% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #29 | $122,128 | 30,007 | $78,789 | 13,655 | +16,352+119.75% | Add |
| Trexquant Investment LP |
| <0.01% | — | #24 | $121,030 | 29,737 | $0 | 0 | +29,737 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #48 | $107,896 | 26,510 | $152,963 | 26,510 | 00.00% | Unchanged |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #42 | $105,165 | 25,839 | $83,371 | 14,449 | +11,390+78.83% | Add |
| Velan Capital Investment Management LP |
| 0.06% | 0.07% | #5 | $101,750 | 25,000 | $103,860 | 18,000 | +7,000+38.89% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $97,057 | 23,847 | $176,850 | 30,650 | -6,803-22.20% | Reduce |
| WealthTrust Asset Management, LLC |
| 0.04% | 0.04% | #7 | $83,093 | 20,416 | $71,640 | 12,416 | +8,000+64.43% | Add |
| Independent Advisor Alliance |
| <0.01% | <0.01% | #19 | $73,769 | 18,125 | $82,110 | 14,230 | +3,895+27.37% | Add |
| RBF Capital, LLC |
| <0.01% | <0.01% | #17 | $70,781 | 17,391 | $100,346 | 17,391 | 00.00% | Unchanged |
| Quadrature Capital Ltd |
| <0.01% | — | #25 | $67,265 | 16,527 | $0 | 0 | +16,527 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #44 | $65,340 | 16,054 | $637,602 | 110,503 | -94,449-85.47% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #43 | $64,991 | 15,958 | $0 | 0 | +15,958 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #45 | $57,879 | 14,221 | $303,987 | 52,684 | -38,463-73.01% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #33 | $55,853 | 13,723 | $67,000 | 11,617 | +2,106+18.13% | Add |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.04% | 0.02% | #8 | $50,875 | 12,500 | $23,080 | 4,000 | +8,500+212.50% | Add |
| Virtu Financial LLC |
| <0.01% | — | #20 | $44,139 | 10,845 | $0 | 0 | +10,845 | New Buy |
| Sigma Planning Corp |
| <0.01% | — | #22 | $41,380 | 10,167 | $0 | 0 | +10,167 | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #50 | $31,770 | 7,806 | $45,041 | 7,806 | 00.00% | Unchanged |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #34 | $20,350 | 5,000 | $0 | 0 | +5,000 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #27 | $10,419 | 2,560 | $802 | 139 | +2,421+1,741.73% | Add |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #37 | $9,015 | 2,215 | $12,781 | 2,215 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #51 | $2,951 | 725 | $4,183 | 725 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #54 | $1,233 | 303 | $30,466 | 5,280 | -4,977-94.26% | Reduce |
| Strengthening Families & Communities, LLC |
| <0.01% | <0.01% | #28 | $1,091 | 268 | $1,546 | 268 | 00.00% | Unchanged |
