| RA CAPITAL MANAGEMENT, L.P. |
| 0.49% | 0.52% | #2 | $56.1M | 21.0M | $49.5M | 21.0M | 00.00% | Unchanged |
| Sands Capital Alternatives, LLC |
| 1.62% | 2.08% | #1 | $9.9M | 3.7M | $8.8M | 3.7M | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #49 | $6.6M | 2.5M | $420,849 | 178,326 | +2.3M+1,296.38% | Add |
| Alyeska Investment Group, L.P. |
| 0.02% | 0.02% | #11 | $6.6M | 2.5M | $5.8M | 2.5M | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #25 | $6.2M | 2.3M | $5.4M | 2.3M | 00.00% | Unchanged |
| ADAR1 Capital Management, LLC |
| 0.26% | 0.3% | #5 | $5.6M | 2.1M | $5.1M | 2.2M | -45,000-2.09% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #51 | $4.5M | 1.7M | $3.6M | 1.5M | +165,795+11.01% | Add |
| Knollwood Investment Advisory, LLC |
| 0.39% | 0.39% | #3 | $4.3M | 1.6M | $3.8M | 1.6M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #41 | $3.0M | 1.1M | $982,755 | 416,238 | +725,620+174.33% | Add |
| Ikarian Capital, LLC |
| 0.3% | 0.2% | #4 | $2.8M | 1.1M | $2.5M | 1.1M | 00.00% | Unchanged |
| Hudson Bay Capital Management LP |
| 0.01% | 0.01% | #16 | $2.5M | 955,000 | $2.3M | 968,940 | -13,940-1.44% | Reduce |
| Pathstone Holdings, LLC |
| 0.01% | 0.01% | #17 | $2.3M | 859,110 | $2.0M | 859,110 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #22 | $1.8M | 675,025 | $1.1M | 473,946 | +201,079+42.43% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #26 | $1.7M | 622,882 | $1.3M | 530,812 | +92,070+17.35% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #57 | $1.6M | 600,528 | $358,078 | 151,728 | +448,800+295.79% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #47 | $963,187 | 360,744 | $177,500 | 75,212 | +285,532+379.64% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #64 | $856,523 | 320,795 | $0 | 0 | +320,795 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #43 | $778,969 | 291,559 | $281,763 | 119,756 | +171,803+143.46% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #40 | $777,611 | 291,240 | $470,173 | 199,226 | +92,014+46.19% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #58 | $733,665 | 274,781 | $755,710 | 320,216 | -45,435-14.19% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #12 | $728,942 | 273,012 | $644,308 | 273,012 | 00.00% | Unchanged |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #30 | $721,802 | 270,338 | $435,000 | 185,850 | +84,488+45.46% | Add |
| NOMURA HOLDINGS INC |
| <0.01% | — | #32 | $506,531 | 189,712 | $0 | 0 | +189,712 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #65 | $495,296 | 185,504 | $1.7M | 713,376 | -527,872-74.00% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #60 | $491,085 | 183,927 | $487,772 | 206,683 | -22,756-11.01% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #14 | $470,377 | 176,171 | $415,764 | 176,171 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #75 | $365,157 | 136,763 | $255,476 | 149,401 | -12,638-8.46% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #56 | $332,086 | 124,377 | $0 | 0 | +124,377 | New Buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #61 | $307,314 | 115,099 | $0 | 0 | +115,099 | New Buy |
| PFG Investments, LLC |
| 0.01% | 0.01% | #13 | $251,648 | 94,250 | $190,806 | 80,850 | +13,400+16.57% | Add |
| CATALYST FINANCIAL PARTNERS LLC |
| 0.02% | 0.02% | #10 | $239,496 | 89,699 | $211,690 | 89,699 | 00.00% | Unchanged |
| Nuveen, LLC |
| <0.01% | — | #62 | $169,158 | 63,355 | $0 | 0 | +63,355 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #55 | $161,797 | 60,598 | $1.6M | 659,675 | -599,077-90.81% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #42 | $139,777 | 52,351 | $35,435 | 15,015 | +37,336+248.66% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #78 | $136,301 | 51,049 | $28,320 | 12,000 | +39,049+325.41% | Add |
| Prospera Financial Services Inc |
| <0.01% | <0.01% | #23 | $133,500 | 50,000 | $118,000 | 50,000 | 00.00% | Unchanged |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #73 | $132,661 | 49,686 | $23,855 | 10,108 | +39,578+391.55% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #48 | $128,465 | 48,114 | $455,218 | 192,889 | -144,775-75.06% | Reduce |
| DEUTSCHE BANK AG\ |
| <0.01% | — | #67 | $123,172 | 46,132 | $0 | 0 | +46,132 | New Buy |
| Verdad Advisers, LP |
| 0.11% | 0.1% | #6 | $118,756 | 44,478 | $87,976 | 37,278 | +7,200+19.31% | Add |
| BARCLAYS PLC |
| <0.01% | <0.01% | #74 | $105,878 | 39,655 | $72,402 | 30,679 | +8,976+29.26% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #82 | $105,003 | 39,327 | $0 | 0 | +39,327 | New Buy |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #50 | $103,099 | 38,614 | $284,116 | 120,388 | -81,774-67.93% | Reduce |
| NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #46 | $96,654 | 36,200 | $0 | 0 | +36,200 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #53 | $93,535 | 35,034 | $0 | 0 | +35,034 | New Buy |
| Rangeley Capital, LLC |
| 0.09% | 0.08% | #7 | $93,450 | 35,000 | $82,600 | 35,000 | 00.00% | Unchanged |
| XTX Topco Ltd |
| <0.01% | — | #28 | $85,798 | 32,134 | $0 | 0 | +32,134 | New Buy |
| Intrepid Financial Planning Group LLC |
| 0.03% | 0.03% | #9 | $80,501 | 30,150 | $71,154 | 30,150 | 00.00% | Unchanged |
| Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #24 | $78,872 | 29,540 | $0 | 0 | +29,540 | New Buy |
| Quantinno Capital Management LP |
| <0.01% | — | #52 | $71,473 | 26,769 | $0 | 0 | +26,769 | New Buy |
