| Jupiter Topco LLC |
| 0.02% | — | #13 | $53.3M | 3.7M | $0 | 0 | +3.7M | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #50 | $47.3M | 3.2M | $39.2M | 3.1M | +140,680+4.53% | Add |
| Krensavage Asset Management, LLC |
| 15.88% | 14.16% | #1 | $41.8M | 2.9M | $36.2M | 2.9M | 00.00% | Unchanged |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.16% | 0.21% | #6 | $35.3M | 2.4M | $36.3M | 2.9M | -453,660-15.80% | Reduce |
| Deep Track Capital, LP |
| 0.31% | 0.4% | #4 | $21.1M | 1.4M | $24.7M | 2.0M | -512,700-26.20% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.9% | 0.04% | #3 | $19.6M | 1.3M | $648,639 | 51,357 | +1.3M+2,517.97% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #64 | $17.7M | 1.2M | $14.9M | 1.2M | +33,720+2.86% | Add |
| Spruce Street Capital LP |
| 3.11% | 2.83% | #2 | $15.9M | 1.1M | $11.8M | 932,598 | +156,133+16.74% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.02% | 0.02% | #14 | $15.7M | 1.1M | $11.1M | 880,023 | +198,294+22.53% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #52 | $14.7M | 1.0M | $12.0M | 948,904 | +62,590+6.60% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #55 | $11.3M | 776,634 | $9.2M | 725,061 | +51,573+7.11% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $9.4M | 643,967 | $11.1M | 882,097 | -238,130-27.00% | Reduce |
| STATE STREET CORP |
| <0.01% | <0.01% | #68 | $8.4M | 576,117 | $7.1M | 562,106 | +14,011+2.49% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #16 | $8.1M | 557,600 | $8.4M | 665,258 | -107,658-16.18% | Reduce |
| Hillsdale Investment Management Inc. |
| 0.16% | 0.15% | #7 | $6.8M | 468,000 | $5.5M | 435,510 | +32,490+7.46% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #57 | $6.8M | 464,649 | $3.3M | 265,088 | +199,561+75.28% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $4.6M | 315,729 | $3.4M | 282,631 | +33,098+11.71% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #58 | $4.4M | 301,151 | $3.7M | 294,971 | +6,180+2.10% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #48 | $4.1M | 282,682 | $2.6M | 203,252 | +79,430+39.08% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #61 | $3.8M | 259,696 | $3.0M | 240,968 | +18,728+7.77% | Add |
| SummitTX Capital, L.P. |
| 0.1% | — | #8 | $3.8M | 257,702 | $0 | 0 | +257,702 | New Buy |
| AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $3.7M | 256,870 | $4.0M | 313,157 | -56,287-17.97% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #56 | $2.7M | 185,618 | $2.2M | 175,856 | +9,762+5.55% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #21 | $2.2M | 153,008 | $1.6M | 125,759 | +27,249+21.67% | Add |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #25 | $2.2M | 150,546 | $32,371 | 2,563 | +147,983+5,773.82% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #35 | $1.9M | 131,995 | $2.7M | 210,070 | -78,075-37.17% | Reduce |
| Opaleye Management Inc. |
| 0.17% | 0.21% | #5 | $1.8M | 125,000 | $1.6M | 125,000 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #90 | $1.4M | 96,764 | $1.3M | 103,059 | -6,295-6.11% | Reduce |
| Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #43 | $1.2M | 84,231 | $914,760 | 72,850 | +11,381+15.62% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #72 | $1.2M | 81,633 | $946,745 | 74,960 | +6,673+8.90% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #38 | $1.2M | 81,005 | $1.5M | 116,961 | -35,956-30.74% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #80 | $1.1M | 77,044 | $3.7M | 293,233 | -216,189-73.73% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #74 | $1.1M | 76,756 | $893,990 | 70,783 | +5,973+8.44% | Add |
| XTX Topco Ltd |
| 0.01% | 0.01% | #15 | $1.1M | 75,468 | $419,455 | 33,211 | +42,257+127.24% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #47 | $1.0M | 71,162 | $3.4M | 267,364 | -196,202-73.38% | Reduce |
| Campbell & CO Investment Adviser LLC |
| 0.05% | 0.03% | #9 | $1.0M | 70,764 | $507,903 | 40,214 | +30,550+75.97% | Add |
| Trexquant Investment LP |
| 0.01% | 0.01% | #19 | $1.0M | 69,613 | $709,389 | 56,167 | +13,446+23.94% | Add |
| MACKENZIE FINANCIAL CORP |
| <0.01% | — | #42 | $982,211 | 67,367 | $0 | 0 | +67,367 | New Buy |
| SEI INVESTMENTS CO |
| <0.01% | <0.01% | #44 | $972,264 | 66,685 | $1.4M | 109,077 | -42,392-38.86% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #81 | $937,771 | 64,319 | $805,844 | 63,804 | +515+0.81% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #92 | $867,948 | 59,530 | $2.3M | 182,002 | -122,472-67.29% | Reduce |
| Nuveen, LLC |
| <0.01% | <0.01% | #73 | $832,970 | 57,131 | $660,170 | 52,270 | +4,861+9.30% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #94 | $832,693 | 57,112 | $459,833 | 36,408 | +20,704+56.87% | Add |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #78 | $707,393 | 48,518 | $845,540 | 66,947 | -18,429-27.53% | Reduce |
| Quantinno Capital Management LP |
| <0.01% | <0.01% | #45 | $657,689 | 45,109 | $443,591 | 35,122 | +9,987+28.44% | Add |
| STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #37 | $596,439 | 40,908 | $235,019 | 18,608 | +22,300+119.84% | Add |
| PRUDENTIAL FINANCIAL INC |
| <0.01% | <0.01% | #54 | $581,232 | 39,865 | $479,877 | 37,995 | +1,870+4.92% | Add |
| IEQ CAPITAL, LLC |
| <0.01% | <0.01% | #27 | $561,447 | 38,508 | $488,427 | 38,672 | -164-0.42% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #34 | $507,224 | 34,789 | $1.1M | 89,599 | -54,810-61.17% | Reduce |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #63 | $504,034 | 34,571 | $396,609 | 31,403 | +3,168+10.09% | Add |
