| Affinity Asset Advisors, LLC |
| 0.32% | 0.3% | #5 | $7.0M | 4.0M | $5.9M | 3.1M | +900,681+28.99% | Add |
| Cormorant Asset Management, LP |
| 0.32% | — | #4 | $6.2M | 3.6M | $0 | 0 | +3.6M | New Buy |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.64% | 0.04% | #1 | $6.2M | 3.5M | $429,400 | 226,000 | +3.3M+1,457.74% | Add |
| Vestal Point Capital, LP |
| 0.11% | — | #8 | $4.6M | 2.6M | $0 | 0 | +2.6M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $3.7M | 2.1M | $2.1M | 1.1M | +1.0M+92.79% | Add |
| Frazier Life Sciences Management, L.P. |
| 0.07% | 0.1% | #10 | $3.4M | 2.0M | $3.7M | 2.0M | 00.00% | Unchanged |
| Ensign Peak Advisors, Inc |
| 0.01% | — | #19 | $3.2M | 1.8M | $0 | 0 | +1.8M | New Buy |
| Woodline Partners LP |
| 0.01% | — | #16 | $3.1M | 1.8M | $0 | 0 | +1.8M | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #25 | $2.9M | 1.7M | $2.9M | 1.5M | +101,623+6.56% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $2.4M | 1.4M | $1.8M | 956,429 | +427,600+44.71% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #21 | $2.0M | 1.2M | $1.9M | 1.0M | +159,938+15.82% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #31 | $2.0M | 1.1M | $551,785 | 290,413 | +831,079+286.17% | Add |
| Ikarian Capital, LLC |
| 0.18% | 0.15% | #7 | $1.7M | 957,062 | $1.8M | 957,062 | 00.00% | Unchanged |
| Sio Capital Management, LLC |
| 0.26% | 0.25% | #6 | $1.6M | 904,268 | $1.7M | 904,268 | 00.00% | Unchanged |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #24 | $1.6M | 904,132 | $1.2M | 620,602 | +283,530+45.69% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $876,650 | 500,816 | $736,602 | 387,567 | +113,249+29.22% | Add |
| Walleye Capital LLC |
| <0.01% | <0.01% | #20 | $875,656 | 500,375 | $738,253 | 388,554 | +111,821+28.78% | Add |
| Squarepoint Ops LLC |
| <0.01% | — | #26 | $873,026 | 498,872 | $0 | 0 | +498,872 | New Buy |
| NOESIS CAPITAL MANGEMENT CORP |
| 0.09% | 0.09% | #9 | $708,750 | 405,000 | $591,850 | 311,500 | +93,500+30.02% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $701,167 | 400,667 | $776,830 | 408,858 | -8,191-2.00% | Reduce |
| Ally Bridge Group (NY) LLC |
| 0.6% | — | #2 | $682,757 | 390,147 | $0 | 0 | +390,147 | New Buy |
| ADAR1 Capital Management, LLC |
| 0.03% | 0.05% | #13 | $657,179 | 375,531 | $892,768 | 469,878 | -94,347-20.08% | Reduce |
| Verdad Advisers, LP |
| 0.5% | 0.12% | #3 | $523,122 | 298,927 | $107,004 | 56,318 | +242,609+430.78% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #32 | $502,031 | 286,875 | $389,529 | 205,015 | +81,860+39.93% | Add |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #18 | $445,221 | 254,412 | $483,383 | 254,412 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $423,528 | 242,016 | $249,309 | 131,215 | +110,801+84.44% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #28 | $354,982 | 202,847 | $0 | 0 | +202,847 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #35 | $350,796 | 200,455 | $380,403 | 200,212 | +243+0.12% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #37 | $298,898 | 170,799 | $268,278 | 141,199 | +29,600+20.96% | Add |
| DAFNA Capital Management LLC |
| 0.06% | 0.08% | #11 | $297,593 | 170,053 | $367,912 | 193,638 | -23,585-12.18% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #36 | $194,808 | 111,319 | $146,916 | 77,324 | +33,995+43.96% | Add |
| Atom Investors LP |
| 0.02% | — | #14 | $177,725 | 101,557 | $0 | 0 | +101,557 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #23 | $101,224 | 57,842 | $118,657 | 62,451 | -4,609-7.38% | Reduce |
| Headlands Technologies LLC |
| 0.01% | <0.01% | #17 | $82,973 | 47,413 | $20,805 | 10,950 | +36,463+333.00% | Add |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | — | #22 | $28,264 | 16,151 | $0 | 0 | +16,151 | New Buy |
| Innovative Asset Advisors Group, LLC |
| 0.01% | — | #15 | $26,250 | 15,000 | $0 | 0 | +15,000 | New Buy |
| Spark Investment Management LLC |
| 0.05% | — | #12 | $23,625 | 13,500 | $0 | 0 | +13,500 | New Buy |
| Bank of New York Mellon Corp |
| <0.01% | — | #41 | $18,614 | 10,637 | $0 | 0 | +10,637 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #49 | $10,201 | 5,897 | $3 | 2 | +5,895+294,750.00% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #40 | $9,555 | 5,460 | $10,374 | 5,460 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #46 | $5,696 | 3,255 | $0 | 0 | +3,255 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #50 | $877 | 501 | $4,129 | 2,173 | -1,672-76.94% | Reduce |
| FMR LLC |
| <0.01% | — | #51 | $757 | 433 | $0 | 0 | +433 | New Buy |
| Fortitude Family Office, LLC |
| <0.01% | <0.01% | #30 | $754 | 431 | $1,212 | 638 | -207-32.45% | Reduce |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #47 | $665 | 380 | $1,110 | 584 | -204-34.93% | Reduce |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #52 | $177 | 101 | $2 | 1 | +100+10,000.00% | Add |
| SHP Wealth Management |
| <0.01% | <0.01% | #38 | $105 | 60 | $114 | 60 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #44 | $74 | 42 | $42 | 22 | +20+90.91% | Add |
| SOA Wealth Advisors, LLC. |
| <0.01% | <0.01% | #43 | $23 | 13 | $25 | 13 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $18 | 10 | $47 | 57 | -47-82.46% | Reduce |
