| Aberdeen Group plc |
| 0.02% | 0.01% | #12 | $12.7M | 824,393 | $9.2M | 8.2M | -7.4M-90.00% | Reduce |
| BVF INC/IL |
| 0.3% | 0.27% | #5 | $11.8M | 765,295 | $8.5M | 7.7M | -6.9M-90.00% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $11.4M | 740,347 | $4.2M | 3.8M | -3.0M-80.41% | Reduce |
| Avidity Partners Management LP |
| 1.65% | 1.51% | #3 | $10.3M | 669,941 | $7.4M | 6.7M | -6.0M-90.00% | Reduce |
| BRAIDWELL LP |
| 0.37% | — | #4 | $9.9M | 645,010 | $0 | 0 | +645,010 | New Buy |
| Laurion Capital Management LP |
| 0.24% | 0.19% | #6 | $9.4M | 610,326 | $4.3M | 3.9M | -3.3M-84.28% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $8.8M | 571,561 | $5.7M | 5.1M | -4.6M-88.88% | Reduce |
| Jones Hill Capital LP |
| 1.76% | — | #2 | $8.3M | 539,814 | $0 | 0 | +539,814 | New Buy |
| Woodline Partners LP |
| 0.02% | <0.01% | #11 | $7.2M | 471,528 | $1.1M | 967,152 | -495,624-51.25% | Reduce |
| Soleus Capital Management, L.P. |
| 0.24% | 0.2% | #7 | $6.9M | 450,000 | $5.0M | 4.5M | -4.1M-90.00% | Reduce |
| Propel Bio Management, LLC |
| 2.61% | 1.65% | #1 | $5.0M | 325,022 | $2.6M | 2.3M | -2.0M-86.14% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #29 | $4.0M | 259,690 | $1.2M | 1.1M | -843,866-76.47% | Reduce |
| Nantahala Capital Management, LLC |
| 0.13% | 0.1% | #8 | $3.9M | 250,646 | $2.8M | 2.5M | -2.3M-90.00% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #28 | $2.7M | 175,756 | $580,305 | 522,797 | -347,041-66.38% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $2.6M | 170,675 | $1.7M | 1.5M | -1.4M-88.81% | Reduce |
| 683 Capital Management, LLC |
| 0.11% | 0.14% | #9 | $2.3M | 147,245 | $2.7M | 2.5M | -2.3M-93.99% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #23 | $2.2M | 139,900 | $167,166 | 150,600 | -10,700-7.10% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #19 | $2.1M | 139,860 | $1.6M | 1.4M | -1.3M-90.00% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $2.0M | 132,791 | $1.1M | 964,230 | -831,439-86.23% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #35 | $1.6M | 104,987 | $895,495 | 806,753 | -701,766-86.99% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #24 | $1.6M | 104,816 | $1.1M | 952,966 | -848,150-89.00% | Reduce |
| Jefferies Financial Group Inc. |
| 0.01% | — | #14 | $1.3M | 84,900 | $0 | 0 | +84,900 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #30 | $1.3M | 82,029 | $822,002 | 740,542 | -658,513-88.92% | Reduce |
| Ikarian Capital, LLC |
| 0.11% | 0.06% | #10 | $1.0M | 67,464 | $748,876 | 674,662 | -607,198-90.00% | Reduce |
| Quadrature Capital Ltd |
| <0.01% | <0.01% | #17 | $580,771 | 37,786 | $32,886 | 29,627 | +8,159+27.54% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $543,790 | 35,380 | $290,140 | 261,387 | -226,007-86.46% | Reduce |
| Simplify Asset Management Inc. |
| 0.01% | 0.01% | #15 | $472,243 | 30,725 | $487,215 | 438,932 | -408,207-93.00% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #40 | $472,166 | 30,720 | $292,294 | 263,328 | -232,608-88.33% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #44 | $365,007 | 23,748 | $2.7M | 3.1M | -3.1M-99.23% | Reduce |
| Brevan Howard Capital Management LP |
| <0.01% | <0.01% | #21 | $356,292 | 23,181 | $50,886 | 45,843 | -22,662-49.43% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #33 | $352,111 | 22,909 | $135,254 | 121,850 | -98,941-81.20% | Reduce |
| Belvedere Trading LLC |
| <0.01% | — | #27 | $313,500 | 20,900 | $0 | 0 | +20,900 | New Buy |
| LPL Financial LLC |
| <0.01% | <0.01% | #38 | $268,068 | 17,441 | $187,923 | 169,300 | -151,859-89.70% | Reduce |
| MML INVESTORS SERVICES, LLC |
| <0.01% | <0.01% | #26 | $225,355 | 14,662 | $100,599 | 90,630 | -75,968-83.82% | Reduce |
| ALPS ADVISORS INC |
| <0.01% | — | #25 | $212,475 | 13,824 | $0 | 0 | +13,824 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | — | #20 | $200,686 | 13,057 | $0 | 0 | +13,057 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | — | #32 | $166,088 | 10,806 | $0 | 0 | +10,806 | New Buy |
| Strategies Wealth Advisors, LLC |
| 0.01% | 0.01% | #13 | $153,700 | 10,000 | $111,000 | 100,000 | -90,000-90.00% | Reduce |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #16 | $98,368 | 6,400 | $0 | 0 | +6,400 | New Buy |
| CITIGROUP INC |
| <0.01% | — | #42 | $70,226 | 4,569 | $0 | 0 | +4,569 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #43 | $48,969 | 3,186 | $35,372 | 31,867 | -28,681-90.00% | Reduce |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #45 | $15,370 | 1,000 | $22,200 | 20,000 | -19,000-95.00% | Reduce |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #51 | $15,000 | 1,000 | $3,000 | 3,005 | -2,005-66.72% | Reduce |
| Providence Capital Advisors, LLC |
| <0.01% | — | #22 | $10,483 | 682 | $0 | 0 | +682 | New Buy |
| BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $7,593 | 494 | $2,695 | 2,428 | -1,934-79.65% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #36 | $5,733 | 373 | $4,179 | 3,765 | -3,392-90.09% | Reduce |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #53 | $2,306 | 150 | $1,671 | 1,505 | -1,355-90.03% | Reduce |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #49 | $2,229 | 145 | $1,889 | 1,702 | -1,557-91.48% | Reduce |
| FMR LLC |
| <0.01% | <0.01% | #55 | $1,968 | 128 | $505 | 455 | -327-71.87% | Reduce |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #50 | $1,537 | 100 | $1,110 | 1,000 | -900-90.00% | Reduce |
